PRDM9 | ENSG00000164256 | NCBI 56979

Details for: PRDM9

Gene ID: 56979

Symbol: PRDM9

Ensembl ID: ENSG00000164256

Description: PR/SET domain 9

Associated with

Cell cycle
(R-HSA-1640170)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Pkmts methylate histone lysines
(R-HSA-3214841)
Reproduction
(R-HSA-1474165)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Double-strand break repair involved in meiotic recombination
(GO:1990918)
Female gamete generation
(GO:0007292)
Histone h3k4 methyltransferase activity
(GO:0042800)
Histone h3k4 trimethyltransferase activity
(GO:0140999)
Histone h3k9 trimethyltransferase activity
(GO:0140949)
Histone h3k36 methyltransferase activity
(GO:0046975)
Histone h3k36 trimethyltransferase activity
(GO:0140955)
Histone h4k20 monomethyltransferase activity
(GO:0140944)
Histone h4k20me methyltransferase activity
(GO:0140941)
Homologous chromosome pairing at meiosis
(GO:0007129)
Male gamete generation
(GO:0048232)
Meiotic gene conversion
(GO:0006311)
Methylation
(GO:0032259)
Negative regulation of apoptotic process
(GO:0043066)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of fertilization
(GO:1905516)
Positive regulation of reciprocal meiotic recombination
(GO:0010845)
Protein homodimerization activity
(GO:0042803)
Recombination hotspot binding
(GO:0010844)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Transcription cis-regulatory region binding
(GO:0000976)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

PR domain zinc finger protein 9

Genular Protein ID: 1484433043

Symbol: PRDM9_HUMAN

Name: PR domain zinc finger protein 9

UniProtKB Accession Codes:

Q9NQV7 B4DX22 Q27Q50

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 10668202

Title: The yin-yang of PR-domain family genes in tumorigenesis.

PubMed ID: 10668202

DOI: 10.14670/hh-15.109

PubMed ID: 24634223

Title: Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.

PubMed ID: 24634223

DOI: 10.1074/jbc.m113.523183

PubMed ID: 27129774

Title: PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.

PubMed ID: 27129774

DOI: 10.1074/jbc.m116.721472

PubMed ID: 18941885

Title: Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.

PubMed ID: 18941885

DOI: 10.1007/s10815-008-9270-x

PubMed ID: 24095733

Title: Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9.

PubMed ID: 24095733

DOI: 10.1016/j.celrep.2013.08.035

PubMed ID: 26833727

Title: Structural basis for human PRDM9 action at recombination hot spots.

PubMed ID: 26833727

DOI: 10.1101/gad.274928.115

Sequence Information:

Length: 894
Mass: 103376
Checksum: DE53094C32EFF83B
Sequence:

MSPEKSQEES PEEDTERTER KPMVKDAFKD ISIYFTKEEW AEMGDWEKTR YRNVKRNYNA 
LITIGLRATR PAFMCHRRQA IKLQVDDTED SDEEWTPRQQ VKPPWMALRV EQRKHQKGMP 
KASFSNESSL KELSRTANLL NASGSEQAQK PVSPSGEAST SGQHSRLKLE LRKKETERKM 
YSLRERKGHA YKEVSEPQDD DYLYCEMCQN FFIDSCAAHG PPTFVKDSAV DKGHPNRSAL 
SLPPGLRIGP SGIPQAGLGV WNEASDLPLG LHFGPYEGRI TEDEEAANNG YSWLITKGRN 
CYEYVDGKDK SWANWMRYVN CARDDEEQNL VAFQYHRQIF YRTCRVIRPG CELLVWYGDE 
YGQELGIKWG SKWKKELMAG REPKPEIHPC PSCCLAFSSQ KFLSQHVERN HSSQNFPGPS 
ARKLLQPENP CPGDQNQEQQ YPDPHSRNDK TKGQEIKERS KLLNKRTWQR EISRAFSSPP 
KGQMGSCRVG KRIMEEESRT GQKVNPGNTG KLFVGVGISR IAKVKYGECG QGFSVKSDVI 
THQRTHTGEK LYVCRECGRG FSWKSHLLIH QRIHTGEKPY VCRECGRGFS WQSVLLTHQR 
THTGEKPYVC RECGRGFSRQ SVLLTHQRRH TGEKPYVCRE CGRGFSRQSV LLTHQRRHTG 
EKPYVCRECG RGFSWQSVLL THQRTHTGEK PYVCRECGRG FSWQSVLLTH QRTHTGEKPY 
VCRECGRGFS NKSHLLRHQR THTGEKPYVC RECGRGFRDK SHLLRHQRTH TGEKPYVCRE 
CGRGFRDKSN LLSHQRTHTG EKPYVCRECG RGFSNKSHLL RHQRTHTGEK PYVCRECGRG 
FRNKSHLLRH QRTHTGEKPY VCRECGRGFS DRSSLCYHQR THTGEKPYVC REDE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRDM9

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The yin-yang of PR-domain family genes in tumorigenesis. PubMed ID: 10668202

Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. PubMed ID: 24634223

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase. PubMed ID: 27129774

Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest. PubMed ID: 18941885

Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9. PubMed ID: 24095733

Structural basis for human PRDM9 action at recombination hot spots. PubMed ID: 26833727