Details for: BAAT

Gene ID: 570

Symbol: BAAT

Ensembl ID: ENSG00000136881

Description: bile acid-CoA:amino acid N-acyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 9.5316
    Cell Significance Index: 160.5600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 7.6613
    Cell Significance Index: 20.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.9214
    Cell Significance Index: 179.1100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.9861
    Cell Significance Index: 7.4800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.7139
    Cell Significance Index: 9.8700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.5014
    Cell Significance Index: 22.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7795
    Cell Significance Index: 148.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6172
    Cell Significance Index: 61.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4873
    Cell Significance Index: 439.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4817
    Cell Significance Index: 13.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4620
    Cell Significance Index: 91.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3938
    Cell Significance Index: 9.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3079
    Cell Significance Index: 50.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2770
    Cell Significance Index: 30.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2373
    Cell Significance Index: 47.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2153
    Cell Significance Index: 4.5900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1997
    Cell Significance Index: 1.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1745
    Cell Significance Index: 4.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1564
    Cell Significance Index: 2.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1390
    Cell Significance Index: 9.6100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1381
    Cell Significance Index: 1.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1213
    Cell Significance Index: 7.2800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1139
    Cell Significance Index: 0.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0993
    Cell Significance Index: 6.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0873
    Cell Significance Index: 3.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0713
    Cell Significance Index: 25.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0702
    Cell Significance Index: 2.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0685
    Cell Significance Index: 42.7700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0497
    Cell Significance Index: 0.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0451
    Cell Significance Index: 5.1500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0373
    Cell Significance Index: 0.9100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0315
    Cell Significance Index: 0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0262
    Cell Significance Index: 0.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0219
    Cell Significance Index: 0.3300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0131
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0117
    Cell Significance Index: 1.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0090
    Cell Significance Index: 1.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0030
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0004
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0002
    Cell Significance Index: -0.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0013
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0029
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0040
    Cell Significance Index: -0.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0057
    Cell Significance Index: -3.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0059
    Cell Significance Index: -2.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -2.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0083
    Cell Significance Index: -2.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0084
    Cell Significance Index: -0.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0090
    Cell Significance Index: -0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0099
    Cell Significance Index: -1.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0103
    Cell Significance Index: -0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0105
    Cell Significance Index: -1.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0113
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0116
    Cell Significance Index: -0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0118
    Cell Significance Index: -1.2100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0147
    Cell Significance Index: -0.1400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0150
    Cell Significance Index: -0.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0156
    Cell Significance Index: -0.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0199
    Cell Significance Index: -2.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0218
    Cell Significance Index: -0.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0229
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0237
    Cell Significance Index: -3.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0258
    Cell Significance Index: -3.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0259
    Cell Significance Index: -0.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0260
    Cell Significance Index: -0.5700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0263
    Cell Significance Index: -0.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0263
    Cell Significance Index: -0.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0275
    Cell Significance Index: -0.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0292
    Cell Significance Index: -0.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0305
    Cell Significance Index: -3.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0417
    Cell Significance Index: -1.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0425
    Cell Significance Index: -2.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0431
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0434
    Cell Significance Index: -1.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0444
    Cell Significance Index: -2.3300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0465
    Cell Significance Index: -0.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0475
    Cell Significance Index: -2.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0480
    Cell Significance Index: -2.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0495
    Cell Significance Index: -3.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0508
    Cell Significance Index: -1.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0524
    Cell Significance Index: -1.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0561
    Cell Significance Index: -1.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0583
    Cell Significance Index: -0.9800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0628
    Cell Significance Index: -0.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0640
    Cell Significance Index: -2.3500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0649
    Cell Significance Index: -0.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BAAT gene is located on chromosome 1p32.3 (Ensembl ID: ENSG00000136881) and is a member of the N-acyltransferase family. The encoded enzyme, BAAT_HUMAN, is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the transfer of an acyl group from CoA to an amino acid, resulting in the formation of a bile acid conjugate. This reaction is essential for the conversion of bile acids from their free form to their conjugated form, which is then excreted into the bile. **Pathways and Functions:** BAAT is involved in various metabolic pathways, including: 1. **Bile acid biosynthesis:** BAAT plays a crucial role in the synthesis of bile acids from cholesterol in the liver. 2. **Bile acid conjugation:** The enzyme facilitates the transfer of an acyl group from CoA to an amino acid, resulting in the formation of a bile acid conjugate. 3. **Fatty acid metabolism:** BAAT is involved in the metabolism of fatty acids, particularly in the breakdown of long-chain fatty acyl-CoA. 4. **Glycine metabolism:** The enzyme participates in the metabolism of glycine, an amino acid involved in various physiological processes. 5. **Steroid metabolism:** BAAT is also involved in the metabolism of steroids, including cholesterol and bile acids. **Clinical Significance:** Dysregulation of the BAAT gene has been implicated in various diseases, including: 1. **Bile acid disorders:** Mutations in the BAAT gene have been associated with bile acid disorders, such as primary biliary cholangitis and primary sclerosing cholangitis. 2. **Metabolic disorders:** BAAT has been linked to metabolic disorders, including obesity, insulin resistance, and fatty liver disease. 3. **Cancer:** The enzyme has been implicated in the development and progression of certain cancers, including colorectal cancer. 4. **Neurological disorders:** BAAT has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the BAAT gene plays a critical role in bile acid metabolism and is involved in various physiological processes, including fatty acid metabolism and glycine metabolism. Dysregulation of the BAAT gene has been implicated in various diseases, highlighting its importance as a therapeutic target for the treatment of metabolic and bile acid disorders.

Genular Protein ID: 2155909131

Symbol: BAAT_HUMAN

Name: Choloyl-CoA hydrolase

UniProtKB Accession Codes:

Q14032 Q3B7W9 Q96L31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChEBI 85 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 4 EMBL 6 ESTHER 1 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 34 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8034703

Title: Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.

PubMed ID: 8034703

DOI: 10.1016/s0021-9258(17)32178-6

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2037576

Title: Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.

PubMed ID: 2037576

DOI: 10.1016/s0021-9258(18)99213-6

PubMed ID: 12239217

Title: Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase.

PubMed ID: 12239217

DOI: 10.1074/jbc.m207463200

PubMed ID: 12810727

Title: The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.

PubMed ID: 12810727

DOI: 10.1074/jbc.m300987200

PubMed ID: 23415802

Title: Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency.

PubMed ID: 23415802

DOI: 10.1053/j.gastro.2013.02.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12704386

Title: Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.

PubMed ID: 12704386

DOI: 10.1038/ng1147

Sequence Information:

  • Length: 418
  • Mass: 46299
  • Checksum: 4B290BAEE97F23B3
  • Sequence:
    • MIQLTATPVS ALVDEPVHIR ATGLIPFQMV SFQASLEDEN GDMFYSQAHY RANEFGEVDL 
NHASSLGGDY MGVHPMGLFW SLKPEKLLTR LLKRDVMNRP FQVQVKLYDL ELIVNNKVAS 
APKASLTLER WYVAPGVTRI KVREGRLRGA LFLPPGEGLF PGVIDLFGGL GGLLEFRASL 
LASRGFASLA LAYHNYEDLP RKPEVTDLEY FEEAANFLLR HPKVFGSGVG VVSVCQGVQI 
GLSMAIYLKQ VTATVLINGT NFPFGIPQVY HGQIHQPLPH SAQLISTNAL GLLELYRTFE 
TTQVGASQYL FPIEEAQGQF LFIVGEGDKT INSKAHAEQA IGQLKRHGKN NWTLLSYPGA 
GHLIEPPYSP LCCASTTHDL RLHWGGEVIP HAAAQEHAWK EIQRFLRKHL IPDVTSQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.