Details for: BAAT

Gene ID: 570

Symbol: BAAT

Ensembl ID: ENSG00000136881

Description: bile acid-CoA:amino acid N-acyltransferase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.15
    Marker Score: 1,221
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.07
    Marker Score: 11,110
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.83
    Marker Score: 11,754
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.79
    Marker Score: 7,714
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.74
    Marker Score: 914
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.51
    Marker Score: 630
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,821
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.14
    Marker Score: 3,734
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.05
    Marker Score: 437
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 690
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.99
    Marker Score: 1,060
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 451
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.86
    Marker Score: 568
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 471
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1,236
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.66
    Marker Score: 1,359
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.64
    Marker Score: 2,621
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 490
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.46
    Marker Score: 4,370
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.45
    Marker Score: 140
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.44
    Marker Score: 3,815
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.39
    Marker Score: 3,688
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.36
    Marker Score: 22,427
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.35
    Marker Score: 13,033
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.33
    Marker Score: 92
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.3
    Marker Score: 297
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.29
    Marker Score: 108
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.26
    Marker Score: 118
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.24
    Marker Score: 2,465
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.23
    Marker Score: 227
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 227
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.21
    Marker Score: 93
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 115
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.2
    Marker Score: 833
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.2
    Marker Score: 3,885
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 111
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.18
    Marker Score: 692
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 401
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.15
    Marker Score: 5,648
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.15
    Marker Score: 144
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.15
    Marker Score: 112
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 451
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.14
    Marker Score: 360
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.13
    Marker Score: 1,970
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.13
    Marker Score: 221
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.13
    Marker Score: 369
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 527
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.12
    Marker Score: 93
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.11
    Marker Score: 519
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.11
    Marker Score: 852
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.11
    Marker Score: 564
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 131
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.11
    Marker Score: 699
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 122
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 142
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.08
    Marker Score: 124
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.07
    Marker Score: 168
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.06
    Marker Score: 854

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BAAT gene is located on chromosome 1p32.3 (Ensembl ID: ENSG00000136881) and is a member of the N-acyltransferase family. The encoded enzyme, BAAT_HUMAN, is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the transfer of an acyl group from CoA to an amino acid, resulting in the formation of a bile acid conjugate. This reaction is essential for the conversion of bile acids from their free form to their conjugated form, which is then excreted into the bile. **Pathways and Functions:** BAAT is involved in various metabolic pathways, including: 1. **Bile acid biosynthesis:** BAAT plays a crucial role in the synthesis of bile acids from cholesterol in the liver. 2. **Bile acid conjugation:** The enzyme facilitates the transfer of an acyl group from CoA to an amino acid, resulting in the formation of a bile acid conjugate. 3. **Fatty acid metabolism:** BAAT is involved in the metabolism of fatty acids, particularly in the breakdown of long-chain fatty acyl-CoA. 4. **Glycine metabolism:** The enzyme participates in the metabolism of glycine, an amino acid involved in various physiological processes. 5. **Steroid metabolism:** BAAT is also involved in the metabolism of steroids, including cholesterol and bile acids. **Clinical Significance:** Dysregulation of the BAAT gene has been implicated in various diseases, including: 1. **Bile acid disorders:** Mutations in the BAAT gene have been associated with bile acid disorders, such as primary biliary cholangitis and primary sclerosing cholangitis. 2. **Metabolic disorders:** BAAT has been linked to metabolic disorders, including obesity, insulin resistance, and fatty liver disease. 3. **Cancer:** The enzyme has been implicated in the development and progression of certain cancers, including colorectal cancer. 4. **Neurological disorders:** BAAT has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the BAAT gene plays a critical role in bile acid metabolism and is involved in various physiological processes, including fatty acid metabolism and glycine metabolism. Dysregulation of the BAAT gene has been implicated in various diseases, highlighting its importance as a therapeutic target for the treatment of metabolic and bile acid disorders.

Genular Protein ID: 2155909131

Symbol: BAAT_HUMAN

Name: Choloyl-CoA hydrolase

UniProtKB Accession Codes:

Q14032 Q3B7W9 Q96L31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChEBI 85 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 4 EMBL 6 ESTHER 1 Ensembl 4 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 34 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8034703

Title: Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.

PubMed ID: 8034703

DOI: 10.1016/s0021-9258(17)32178-6

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2037576

Title: Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.

PubMed ID: 2037576

DOI: 10.1016/s0021-9258(18)99213-6

PubMed ID: 12239217

Title: Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase.

PubMed ID: 12239217

DOI: 10.1074/jbc.m207463200

PubMed ID: 12810727

Title: The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.

PubMed ID: 12810727

DOI: 10.1074/jbc.m300987200

PubMed ID: 23415802

Title: Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency.

PubMed ID: 23415802

DOI: 10.1053/j.gastro.2013.02.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12704386

Title: Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.

PubMed ID: 12704386

DOI: 10.1038/ng1147

Sequence Information:

  • Length: 418
  • Mass: 46299
  • Checksum: 4B290BAEE97F23B3
  • Sequence:
    • MIQLTATPVS ALVDEPVHIR ATGLIPFQMV SFQASLEDEN GDMFYSQAHY RANEFGEVDL 
NHASSLGGDY MGVHPMGLFW SLKPEKLLTR LLKRDVMNRP FQVQVKLYDL ELIVNNKVAS 
APKASLTLER WYVAPGVTRI KVREGRLRGA LFLPPGEGLF PGVIDLFGGL GGLLEFRASL 
LASRGFASLA LAYHNYEDLP RKPEVTDLEY FEEAANFLLR HPKVFGSGVG VVSVCQGVQI 
GLSMAIYLKQ VTATVLINGT NFPFGIPQVY HGQIHQPLPH SAQLISTNAL GLLELYRTFE 
TTQVGASQYL FPIEEAQGQF LFIVGEGDKT INSKAHAEQA IGQLKRHGKN NWTLLSYPGA 
GHLIEPPYSP LCCASTTHDL RLHWGGEVIP HAAAQEHAWK EIQRFLRKHL IPDVTSQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.