Details for: AKR1B10

Gene ID: 57016

Symbol: AKR1B10

Ensembl ID: ENSG00000198074

Description: aldo-keto reductase family 1 member B10

Associated with

Other Information

Genular Protein ID: 3522921421

Symbol: AK1BA_HUMAN

Name: Aldo-keto reductase family 1 member B10

UniProtKB Accession Codes:

O60218 A4D1P1 O75890 Q6FHF3 Q8IWZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 61 ChEMBL 1 ChiTaRS 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 20 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 11 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9565553

Title: Identification and characterization of a novel human aldose reductase-like gene.

PubMed ID: 9565553

DOI: 10.1074/jbc.273.19.11429

PubMed ID: 9765596

Title: Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family.

PubMed ID: 9765596

DOI: 10.1016/s0167-4781(98)00109-2

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9537432

Title: New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma.

PubMed ID: 9537432

DOI: 10.1002/hep.510270408

PubMed ID: 12732097

Title: Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.

PubMed ID: 12732097

DOI: 10.1042/bj20021818

PubMed ID: 15755999

Title: Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.

PubMed ID: 15755999

DOI: 10.1158/1078-0432.ccr-04-1238

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21585341

Title: Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway.

PubMed ID: 21585341

DOI: 10.1042/bj20110111

PubMed ID: 19563777

Title: Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels.

PubMed ID: 19563777

DOI: 10.1016/j.bbrc.2009.06.123

PubMed ID: 19013440

Title: Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes.

PubMed ID: 19013440

DOI: 10.1016/j.cbi.2008.10.021

PubMed ID: 18087047

Title: Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.

PubMed ID: 18087047

DOI: 10.1073/pnas.0705659105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 316
  • Mass: 36020
  • Checksum: 0C2FC0E798955A33
  • Sequence:
    • MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ 
EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD 
DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP 
VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK 
HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN 
VLQSSHLEDY PFNAEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.