Adam17 | ENSRNOG00000060694 | NCBI 57027

Details for: Adam17

Gene ID: 57027

Symbol: Adam17

Ensembl ID: ENSRNOG00000060694

Description: ADAM metallopeptidase domain 17

Associated with

Death receptor signaling
(R-RNO-73887)
P75 ntr receptor-mediated signalling
(R-RNO-193704)
Regulated proteolysis of p75ntr
(R-RNO-193692)
Signal transduction
(R-RNO-162582)
Tnf signaling
(R-RNO-75893)
Actin cytoskeleton
(GO:0015629)
Amyloid precursor protein catabolic process
(GO:0042987)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
B cell differentiation
(GO:0030183)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell motility
(GO:0048870)
Cell surface
(GO:0009986)
Cellular response to high density lipoprotein particle stimulus
(GO:0071403)
Commissural neuron axon guidance
(GO:0071679)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to gram-positive bacterium
(GO:0050830)
Endopeptidase activity
(GO:0004175)
Focal adhesion
(GO:0005925)
Germinal center formation
(GO:0002467)
Integrin binding
(GO:0005178)
Interleukin-6 receptor binding
(GO:0005138)
Membrane
(GO:0016020)
Membrane protein ectodomain proteolysis
(GO:0006509)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Metallodipeptidase activity
(GO:0070573)
Metalloendopeptidase activity
(GO:0004222)
Metalloendopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902945)
Metallopeptidase activity
(GO:0008237)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Notch binding
(GO:0005112)
Notch receptor processing
(GO:0007220)
Notch signaling pathway
(GO:0007219)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of t cell chemotaxis
(GO:0010820)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Production of molecular mediator involved in inflammatory response
(GO:0002532)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of axon regeneration
(GO:0048679)
Regulation of cellular component organization
(GO:0051128)
Regulation of mast cell apoptotic process
(GO:0033025)
Regulation of neuron migration
(GO:2001222)
Response to antineoplastic agent
(GO:0097327)
Response to hypobaric hypoxia
(GO:1990910)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to xenobiotic stimulus
(GO:0009410)
Ruffle membrane
(GO:0032587)
Sh3 domain binding
(GO:0017124)
Signaling receptor ligand precursor processing
(GO:0140448)
Spermatogenesis
(GO:0007283)
Spleen development
(GO:0048536)
T cell differentiation in thymus
(GO:0033077)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor binding
(GO:0043120)
Wound healing, spreading of epidermal cells
(GO:0035313)

Other Information

Proteins

Disintegrin and metalloproteinase domain-containing protein 17

Genular Protein ID: 3972548446

Symbol: ADA17_RAT

Name: Disintegrin and metalloproteinase domain-containing protein 17

UniProtKB Accession Codes:

Q9Z1K9

Database IDs:

Citations:

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 26479776

Title: Peptidomics for studying limited proteolysis.

PubMed ID: 26479776

DOI: 10.1021/acs.jproteome.5b00820

Sequence Information:

Length: 827
Mass: 93017
Checksum: EF82239C067F2AFF
Sequence:

MRQRLLFLTT LVPFVLAPRP PEEPGSGSHL RLEKLDSLLS DYDILSLSNI QQHSIRKRDL 
QSATHLETLL TFSALKRHFK LYLTSSTERF SQNLRVVVVD GKEESEYSVK WQDFFSGHVV 
GEPDSRVLAH IGDDDVTVRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKDFSRLQS 
PKVCGYLNAD SEELLPKGLI DREPSEEFVR RVKRRAEPNP LKNTCKLLVV ADHRFYKYMG 
RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGVQIE QIRILKSPQE VKPGERHFNM 
AKSFPNEEKD AWDVKMLLEQ FSLDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 
HGGVCPKAYY NPGVKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 
AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 
SRVDEGEECD PGIMYLNNDT CCNSDCTLKP GVQCSDRNSP CCKNCQFETA QKKCQEAINA 
TCKGVSYCTG NSSECPPPGD AEDDTVCLDL GKCKAGKCIP FCKREQELES CACADTDNSC 
KVCCRNLSGP CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 
INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHH SNIEMLSSMD 
SASVRIIKPF PAPQTPGRLQ ALQPAAMMPP VSAAPKLDHQ RMDTIQEDPS TDSHVDDDGF 
EKDPFPNSSA AAKSFEDLTD HPVTRSEKAA SFKLQRQSRV DSKETEC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.