Details for: BACH1

Gene ID: 571

Symbol: BACH1

Ensembl ID: ENSG00000156273

Description: BTB domain and CNC homolog 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.52
    Marker Score: 13,826
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.12
    Marker Score: 1,126
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.5
    Marker Score: 84,359
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.43
    Marker Score: 8,647
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.43
    Marker Score: 2,152
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.31
    Marker Score: 1,150
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.3
    Marker Score: 2,644
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.28
    Marker Score: 2,844
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.14
    Marker Score: 47,766
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.01
    Marker Score: 112,191
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.97
    Marker Score: 2,233
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.96
    Marker Score: 725
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.9
    Marker Score: 2,031
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.9
    Marker Score: 28,366
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.85
    Marker Score: 14,146
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.84
    Marker Score: 36,636
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.77
    Marker Score: 784
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.77
    Marker Score: 3,401
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.76
    Marker Score: 1,358
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.72
    Marker Score: 933
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.7
    Marker Score: 1,676
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7
    Marker Score: 57,733
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.69
    Marker Score: 2,959
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.69
    Marker Score: 1,174
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.67
    Marker Score: 61,687
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.63
    Marker Score: 5,473
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.62
    Marker Score: 489
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.61
    Marker Score: 60,986
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.6
    Marker Score: 604
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.58
    Marker Score: 946
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.56
    Marker Score: 3,034
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.55
    Marker Score: 13,622
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.53
    Marker Score: 3,348
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.52
    Marker Score: 490
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.52
    Marker Score: 5,869
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.52
    Marker Score: 15,666
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.52
    Marker Score: 1,309
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.51
    Marker Score: 367
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.51
    Marker Score: 3,563
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.51
    Marker Score: 3,158
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.47
    Marker Score: 6,787
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.47
    Marker Score: 23,530
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.46
    Marker Score: 1,569
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,551
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.44
    Marker Score: 866
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.43
    Marker Score: 754
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.42
    Marker Score: 25,158
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.41
    Marker Score: 1,061
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.4
    Marker Score: 1,338
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.39
    Marker Score: 16,202
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.39
    Marker Score: 778
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.38
    Marker Score: 3,338
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.38
    Marker Score: 5,730
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.37
    Marker Score: 5,751
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.37
    Marker Score: 486
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.37
    Marker Score: 1,942
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.37
    Marker Score: 433
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.37
    Marker Score: 511
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.36
    Marker Score: 3,389
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.36
    Marker Score: 1,682
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.34
    Marker Score: 1,436
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.34
    Marker Score: 34,309
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.34
    Marker Score: 1,531
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.33
    Marker Score: 1,399
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.33
    Marker Score: 451
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.3
    Marker Score: 411
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.3
    Marker Score: 5,402
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.28
    Marker Score: 3,156
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.28
    Marker Score: 5,219
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.28
    Marker Score: 1,542
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.28
    Marker Score: 8,201
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.27
    Marker Score: 2,216
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.26
    Marker Score: 362
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.25
    Marker Score: 2,276
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.25
    Marker Score: 606
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.24
    Marker Score: 2,817
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.22
    Marker Score: 696
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.22
    Marker Score: 710
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.21
    Marker Score: 309
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.21
    Marker Score: 6,354
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.19
    Marker Score: 372
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.18
    Marker Score: 4,922
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.18
    Marker Score: 568
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.18
    Marker Score: 1,002
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.16
    Marker Score: 679
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.16
    Marker Score: 1,398
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.16
    Marker Score: 1,279
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.15
    Marker Score: 645
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.14
    Marker Score: 334
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.14
    Marker Score: 1,212
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.13
    Marker Score: 629
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.12
    Marker Score: 1,121
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.11
    Marker Score: 1,616
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.1
    Marker Score: 1,091
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.1
    Marker Score: 4,741
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.08
    Marker Score: 627
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.07
    Marker Score: 1,579
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.07
    Marker Score: 3,495
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.06
    Marker Score: 6,435
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.06
    Marker Score: 384

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** BACH1 is a transcriptional regulator that interacts with RNA polymerase II to modulate gene expression. It possesses both activator and repressor functions, depending on the context, and regulates the expression of various genes involved in cellular stress response and DNA repair. 2. **DNA Repair:** BACH1 is involved in DNA repair processes, particularly in the repair of oxidative damage caused by reactive oxygen species (ROS). 3. **Keap1-Nrf2 Pathway:** BACH1 acts as a negative regulator of Nrf2 activity, modulating the expression of antioxidant and detoxification enzymes. This interaction highlights the importance of BACH1 in maintaining cellular antioxidant defenses. 4. **Cellular Stress Response:** BACH1 is involved in cellular stress response, including responses to chemical stress, oxidative stress, and other forms of cellular stress. **Pathways and Functions:** 1. **Keap1-Nrf2 Pathway:** BACH1 interacts with Keap1 to modulate Nrf2 activity, thereby regulating the expression of antioxidant and detoxification enzymes. 2. **DNA Repair:** BACH1 is involved in DNA repair processes, particularly in the repair of oxidative damage caused by ROS. 3. **Transcriptional Regulation:** BACH1 regulates the expression of various genes involved in cellular stress response and DNA repair. 4. **Cytoprotection:** BACH1 plays a role in cytoprotection, particularly in the regulation of the expression of hmox1, a cytoprotective gene. **Clinical Significance:** BACH1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Its dysregulation has been associated with an increased risk of these diseases, highlighting the importance of BACH1 in maintaining cellular homeostasis. Further research is needed to fully understand the role of BACH1 in disease pathogenesis and to explore potential therapeutic strategies targeting this gene. **Significantly Expressed Cells:** 1. **Skeletal Muscle Fiber** 2. **Mature Microglial Cell** 3. **Purkinje Cell** 4. **Regular Atrial Cardiac Myocyte** 5. **Basal Epithelial Cell of Prostatic Duct** 6. **Central Nervous System Macrophage** 7. **Vascular Leptomeningeal Cell** 8. **Cardiac Neuron** 9. **Regular Ventricular Cardiac Myocyte** 10. **CD14-positive, CD16-negative Classical Monocyte** **Proteins:** BACH1_HUMAN (HA2303) In conclusion, BACH1 is a critical transcriptional regulator involved in various cellular processes, including stress response, DNA repair, and transcriptional regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of BACH1 in maintaining cellular homeostasis. Further research is needed to fully understand the role of BACH1 in disease pathogenesis and to explore potential therapeutic strategies targeting this gene.

Genular Protein ID: 3188751847

Symbol: BACH1_HUMAN

Name: HA2303

UniProtKB Accession Codes:

O14867 O43285 Q6ICU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 13 DIP 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9544839

Title: Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1.

PubMed ID: 9544839

DOI: 10.1007/s004390050692

PubMed ID: 9479503

Title: Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1.

PubMed ID: 9479503

DOI: 10.1006/geno.1997.5080

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24035498

Title: Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.

PubMed ID: 24035498

DOI: 10.1016/j.molcel.2013.08.018

Sequence Information:

  • Length: 736
  • Mass: 81958
  • Checksum: CAAEECC63D46571B
  • Sequence:
    • MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS VLAACSSYFH 
SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK ENVDEVCKCV EFLSVHNIEE 
SCFQFLKFKF LDSTADQQEC PRKKCFSSHC QKTDLKLSLL DQRDLETDEV EEFLENKNVQ 
TPQCKLRRYQ GNAKASPPLQ DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR 
TGESSVKDIH ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP 
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP LSGTDVQEKT 
FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG FWSDICSTDT PCQMQLSPAV 
AKDGSEQISQ KRSECPWLGI RISESPEPGQ RTFTTLSSVN CPFISTLSTE GCSSNLEIGN 
DDYVSEPQQE PCPYACVISL GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND 
FQSLLKMHKL TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL 
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF LISEKDKSTP 
DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ MSTATSEQAG PAEQCRQSGG 
ISDFCQQMTD KCTTDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.