Details for: BACH1

Gene ID: 571

Symbol: BACH1

Ensembl ID: ENSG00000156273

Description: BTB domain and CNC homolog 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 338.6796
    Cell Significance Index: -52.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.1770
    Cell Significance Index: -53.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.4438
    Cell Significance Index: -55.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.0072
    Cell Significance Index: -45.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.3613
    Cell Significance Index: -51.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.6336
    Cell Significance Index: -56.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.2224
    Cell Significance Index: -46.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.9107
    Cell Significance Index: -54.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.7584
    Cell Significance Index: -52.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.9705
    Cell Significance Index: -39.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.8873
    Cell Significance Index: -54.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3324
    Cell Significance Index: -40.9500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 4.9637
    Cell Significance Index: 80.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.2058
    Cell Significance Index: 102.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.7666
    Cell Significance Index: 96.8200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.8073
    Cell Significance Index: 24.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3634
    Cell Significance Index: 181.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1769
    Cell Significance Index: 40.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1761
    Cell Significance Index: 122.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0146
    Cell Significance Index: 56.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9882
    Cell Significance Index: 394.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7393
    Cell Significance Index: 120.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6234
    Cell Significance Index: 84.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3422
    Cell Significance Index: 29.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2632
    Cell Significance Index: 453.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1507
    Cell Significance Index: 70.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0921
    Cell Significance Index: 27.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0292
    Cell Significance Index: 27.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8192
    Cell Significance Index: 13.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7999
    Cell Significance Index: 130.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7535
    Cell Significance Index: 21.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5838
    Cell Significance Index: 35.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5331
    Cell Significance Index: 15.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5091
    Cell Significance Index: 12.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4727
    Cell Significance Index: 6.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4549
    Cell Significance Index: 53.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4164
    Cell Significance Index: 51.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3679
    Cell Significance Index: 7.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3519
    Cell Significance Index: 155.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3410
    Cell Significance Index: 46.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3062
    Cell Significance Index: 55.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2928
    Cell Significance Index: 28.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2611
    Cell Significance Index: 142.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2325
    Cell Significance Index: 160.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1874
    Cell Significance Index: 352.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1783
    Cell Significance Index: 33.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1579
    Cell Significance Index: 31.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1438
    Cell Significance Index: 6.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1357
    Cell Significance Index: 4.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1308
    Cell Significance Index: 0.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1230
    Cell Significance Index: 78.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1146
    Cell Significance Index: 52.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0877
    Cell Significance Index: 14.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0731
    Cell Significance Index: 4.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0354
    Cell Significance Index: 48.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0316
    Cell Significance Index: 48.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0089
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0059
    Cell Significance Index: 10.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0314
    Cell Significance Index: -23.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0481
    Cell Significance Index: -35.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0489
    Cell Significance Index: -30.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0648
    Cell Significance Index: -49.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0675
    Cell Significance Index: -7.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0704
    Cell Significance Index: -39.7000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1224
    Cell Significance Index: -1.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1227
    Cell Significance Index: -5.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1238
    Cell Significance Index: -12.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1348
    Cell Significance Index: -1.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1378
    Cell Significance Index: -7.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1386
    Cell Significance Index: -17.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1566
    Cell Significance Index: -45.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1580
    Cell Significance Index: -22.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1782
    Cell Significance Index: -37.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1873
    Cell Significance Index: -21.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2181
    Cell Significance Index: -28.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2282
    Cell Significance Index: -23.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2685
    Cell Significance Index: -7.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3646
    Cell Significance Index: -27.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3825
    Cell Significance Index: -10.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4319
    Cell Significance Index: -6.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4444
    Cell Significance Index: -50.7300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4600
    Cell Significance Index: -6.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4856
    Cell Significance Index: -10.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5008
    Cell Significance Index: -35.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5123
    Cell Significance Index: -10.9100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5298
    Cell Significance Index: -7.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5755
    Cell Significance Index: -36.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5956
    Cell Significance Index: -47.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6587
    Cell Significance Index: -44.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6885
    Cell Significance Index: -42.2100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7851
    Cell Significance Index: -9.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8045
    Cell Significance Index: -42.2400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.8230
    Cell Significance Index: -12.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9006
    Cell Significance Index: -24.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9023
    Cell Significance Index: -28.9000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9896
    Cell Significance Index: -12.4900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.9963
    Cell Significance Index: -4.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0233
    Cell Significance Index: -45.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0317
    Cell Significance Index: -35.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** BACH1 is a transcriptional regulator that interacts with RNA polymerase II to modulate gene expression. It possesses both activator and repressor functions, depending on the context, and regulates the expression of various genes involved in cellular stress response and DNA repair. 2. **DNA Repair:** BACH1 is involved in DNA repair processes, particularly in the repair of oxidative damage caused by reactive oxygen species (ROS). 3. **Keap1-Nrf2 Pathway:** BACH1 acts as a negative regulator of Nrf2 activity, modulating the expression of antioxidant and detoxification enzymes. This interaction highlights the importance of BACH1 in maintaining cellular antioxidant defenses. 4. **Cellular Stress Response:** BACH1 is involved in cellular stress response, including responses to chemical stress, oxidative stress, and other forms of cellular stress. **Pathways and Functions:** 1. **Keap1-Nrf2 Pathway:** BACH1 interacts with Keap1 to modulate Nrf2 activity, thereby regulating the expression of antioxidant and detoxification enzymes. 2. **DNA Repair:** BACH1 is involved in DNA repair processes, particularly in the repair of oxidative damage caused by ROS. 3. **Transcriptional Regulation:** BACH1 regulates the expression of various genes involved in cellular stress response and DNA repair. 4. **Cytoprotection:** BACH1 plays a role in cytoprotection, particularly in the regulation of the expression of hmox1, a cytoprotective gene. **Clinical Significance:** BACH1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Its dysregulation has been associated with an increased risk of these diseases, highlighting the importance of BACH1 in maintaining cellular homeostasis. Further research is needed to fully understand the role of BACH1 in disease pathogenesis and to explore potential therapeutic strategies targeting this gene. **Significantly Expressed Cells:** 1. **Skeletal Muscle Fiber** 2. **Mature Microglial Cell** 3. **Purkinje Cell** 4. **Regular Atrial Cardiac Myocyte** 5. **Basal Epithelial Cell of Prostatic Duct** 6. **Central Nervous System Macrophage** 7. **Vascular Leptomeningeal Cell** 8. **Cardiac Neuron** 9. **Regular Ventricular Cardiac Myocyte** 10. **CD14-positive, CD16-negative Classical Monocyte** **Proteins:** BACH1_HUMAN (HA2303) In conclusion, BACH1 is a critical transcriptional regulator involved in various cellular processes, including stress response, DNA repair, and transcriptional regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of BACH1 in maintaining cellular homeostasis. Further research is needed to fully understand the role of BACH1 in disease pathogenesis and to explore potential therapeutic strategies targeting this gene.

Genular Protein ID: 3188751847

Symbol: BACH1_HUMAN

Name: HA2303

UniProtKB Accession Codes:

O14867 O43285 Q6ICU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 13 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9544839

Title: Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1.

PubMed ID: 9544839

DOI: 10.1007/s004390050692

PubMed ID: 9479503

Title: Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1.

PubMed ID: 9479503

DOI: 10.1006/geno.1997.5080

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24035498

Title: Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.

PubMed ID: 24035498

DOI: 10.1016/j.molcel.2013.08.018

Sequence Information:

  • Length: 736
  • Mass: 81958
  • Checksum: CAAEECC63D46571B
  • Sequence:
    • MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS VLAACSSYFH 
SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK ENVDEVCKCV EFLSVHNIEE 
SCFQFLKFKF LDSTADQQEC PRKKCFSSHC QKTDLKLSLL DQRDLETDEV EEFLENKNVQ 
TPQCKLRRYQ GNAKASPPLQ DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR 
TGESSVKDIH ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP 
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP LSGTDVQEKT 
FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG FWSDICSTDT PCQMQLSPAV 
AKDGSEQISQ KRSECPWLGI RISESPEPGQ RTFTTLSSVN CPFISTLSTE GCSSNLEIGN 
DDYVSEPQQE PCPYACVISL GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND 
FQSLLKMHKL TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL 
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF LISEKDKSTP 
DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ MSTATSEQAG PAEQCRQSGG 
ISDFCQQMTD KCTTDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.