TIGAR | ENSG00000078237 | NCBI 57103

Details for: TIGAR

Gene ID: 57103

Symbol: TIGAR

Ensembl ID: ENSG00000078237

Description: TP53 induced glycolysis regulatory phosphatase

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cardiac muscle cell apoptotic process
(GO:0010659)
Cellular response to cobalt ion
(GO:0071279)
Cellular response to hypoxia
(GO:0071456)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Fructose-2,6-bisphosphate 2-phosphatase activity
(GO:0004331)
Fructose 2,6-bisphosphate metabolic process
(GO:0006003)
Glucose catabolic process to lactate via pyruvate
(GO:0019661)
Glycolytic process
(GO:0006096)
Intestinal epithelial cell development
(GO:0060576)
Mitochondrial outer membrane
(GO:0005741)
Mitophagy
(GO:0000423)
Negative regulation of glucose catabolic process to lactate via pyruvate
(GO:1904024)
Negative regulation of glycolytic process
(GO:0045820)
Negative regulation of mitophagy
(GO:1901525)
Negative regulation of programmed cell death
(GO:0043069)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Nucleus
(GO:0005634)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of dna repair
(GO:0045739)
Positive regulation of hexokinase activity
(GO:1903301)
Positive regulation of pentose-phosphate shunt
(GO:1905857)
Protein binding
(GO:0005515)
Reactive oxygen species metabolic process
(GO:0072593)
Regulation of pentose-phosphate shunt
(GO:0043456)
Regulation of response to dna damage checkpoint signaling
(GO:1902153)
Response to gamma radiation
(GO:0010332)
Response to ischemia
(GO:0002931)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

TIGAR_HUMAN

Genular Protein ID: 60653050

Symbol: TIGAR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NQ88 B2R840

Database IDs:

Citations:

PubMed ID: 11062477

Title: Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.

PubMed ID: 11062477

DOI: 10.1038/81664

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16140933

Title: Identification of novel p53 target genes in ionizing radiation response.

PubMed ID: 16140933

DOI: 10.1158/0008-5472.can-05-1039

PubMed ID: 16839880

Title: TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

PubMed ID: 16839880

DOI: 10.1016/j.cell.2006.05.036

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19713938

Title: Modulation of intracellular ROS levels by TIGAR controls autophagy.

PubMed ID: 19713938

DOI: 10.1038/emboj.2009.242

PubMed ID: 19015259

Title: Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator).

PubMed ID: 19015259

DOI: 10.1074/jbc.m807821200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21820150

Title: Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer.

PubMed ID: 21820150

DOI: 10.1016/j.humpath.2011.04.021

PubMed ID: 22887998

Title: Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis.

PubMed ID: 22887998

DOI: 10.1074/jbc.m112.384578

PubMed ID: 23185017

Title: Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death.

PubMed ID: 23185017

DOI: 10.1073/pnas.1206530109

PubMed ID: 23817040

Title: Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells.

PubMed ID: 23817040

DOI: 10.1016/j.bbrc.2013.06.072

PubMed ID: 23726973

Title: TIGAR is required for efficient intestinal regeneration and tumorigenesis.

PubMed ID: 23726973

DOI: 10.1016/j.devcel.2013.05.001

PubMed ID: 25928429

Title: TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway.

PubMed ID: 25928429

DOI: 10.1038/srep09853

Sequence Information:

Length: 270
Mass: 30063
Checksum: B85D59659AD96E39
Sequence:

MARFALTVVR HGETRFNKEK IIQGQGVDEP LSETGFKQAA AAGIFLNNVK FTHAFSSDLM 
RTKQTMHGIL ERSKFCKDMT VKYDSRLRER KYGVVEGKAL SELRAMAKAA REECPVFTPP 
GGETLDQVKM RGIDFFEFLC QLILKEADQK EQFSQGSPSN CLETSLAEIF PLGKNHSSKV 
NSDSGIPGLA ASVLVVSHGA YMRSLFDYFL TDLKCSLPAT LSRSELMSVT PNTGMSLFII 
NFEEGREVKP TVQCICMNLQ DHLNGLTETR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TIGAR

Associated with

Other Information

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. PubMed ID: 11062477

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel p53 target genes in ionizing radiation response. PubMed ID: 16140933

TIGAR, a p53-inducible regulator of glycolysis and apoptosis. PubMed ID: 16839880

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Modulation of intracellular ROS levels by TIGAR controls autophagy. PubMed ID: 19713938

Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). PubMed ID: 19015259

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. PubMed ID: 21820150

Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis. PubMed ID: 22887998

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. PubMed ID: 23185017

Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells. PubMed ID: 23817040

TIGAR is required for efficient intestinal regeneration and tumorigenesis. PubMed ID: 23726973

TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway. PubMed ID: 25928429