Details for: LYRM4

Gene ID: 57128

Symbol: LYRM4

Ensembl ID: ENSG00000214113

Description: LYR motif containing 4

Associated with

Other Information

Genular Protein ID: 3295730525

Symbol: LYRM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HD34 A8K543 Q5XKP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 11 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11342225

Title: Identification of the human crooked neck gene by comparative gene identification.

PubMed ID: 11342225

DOI: 10.1016/s0167-4781(00)00295-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17331979

Title: Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones.

PubMed ID: 17331979

DOI: 10.1093/hmg/ddm038

PubMed ID: 18650437

Title: A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis.

PubMed ID: 18650437

DOI: 10.1074/jbc.m804064200

PubMed ID: 19454487

Title: Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.

PubMed ID: 19454487

DOI: 10.1093/hmg/ddp239

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21298097

Title: Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex.

PubMed ID: 21298097

DOI: 10.1371/journal.pone.0016199

PubMed ID: 23593335

Title: The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans.

PubMed ID: 23593335

DOI: 10.1371/journal.pone.0060869

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29097656

Title: Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.

PubMed ID: 29097656

DOI: 10.1038/s41467-017-01497-1

PubMed ID: 31664822

Title: Structure of the Human ACP-ISD11 Heterodimer.

PubMed ID: 31664822

DOI: 10.1021/acs.biochem.9b00539

PubMed ID: 31101807

Title: Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.

PubMed ID: 31101807

DOI: 10.1038/s41467-019-09989-y

PubMed ID: 34824239

Title: N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization.

PubMed ID: 34824239

DOI: 10.1038/s41467-021-27122-w

PubMed ID: 23814038

Title: Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.

PubMed ID: 23814038

DOI: 10.1093/hmg/ddt295

Sequence Information:

  • Length: 91
  • Mass: 10758
  • Checksum: F0C5919CA701F3F3
  • Sequence:
    • MAASSRAQVL SLYRAMLRES KRFSAYNYRT YAVRRIRDAF RENKNVKDPV EIQTLVNKAK 
RDLGVIRRQV HIGQLYSTDK LIIENRDMPR T

Genular Protein ID: 1174955867

Symbol: F5H189_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H189

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 130
  • Mass: 15194
  • Checksum: 362FFA7AE9A63C3C
  • Sequence:
    • MAASSRAQVL SLYRAMLRES KRFSAYNYRT YAVRRIRDAF RENKNVKDPV EIQTLVNKAK 
RDLGVIRRQM DSHSVAQAGV HWNDLSSLQP LPPWFKQFSC LSLPSSWDYR RTPPRLANFC 
ILSRDVISLY

Genular Protein ID: 1878557599

Symbol: C9JY28_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JY28

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 70
  • Mass: 8248
  • Checksum: 9625A26219346332
  • Sequence:
    • MAASSRAQVL SLYRAMLRES KRFSAYNYRT YAVRRIRDAF RENKNVKDPV EIQTLVNKAK 
RDLGVIRRQA

Genular Protein ID: 1740067417

Symbol: C9JRX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JRX8

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 96
  • Mass: 10991
  • Checksum: 22F8CBECEDA131E5
  • Sequence:
    • MAASSRAQVL SLYRAMLRES KRFSAYNYRT YAVRRIRDAF RENKNVKDPV EIQTLVNKAK 
RDLGVIRRQV AEQGTAARRK SGNSSRSLGK PCTSWP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.