Details for: PAK5

Gene ID: 57144

Symbol: PAK5

Ensembl ID: ENSG00000101349

Description: p21 (RAC1) activated kinase 5

Associated with

Other Information

Genular Protein ID: 2496567393

Symbol: PAK5_HUMAN

Name: p21-activated kinase 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12032833

Title: Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain.

PubMed ID: 12032833

DOI: 10.1038/sj.onc.1205478

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12860998

Title: Identification of an autoinhibitory domain of p21-activated protein kinase 5.

PubMed ID: 12860998

DOI: 10.1074/jbc.c300234200

PubMed ID: 12897128

Title: p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.

PubMed ID: 12897128

DOI: 10.1128/mcb.23.16.5526-5539.2003

PubMed ID: 16014608

Title: PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.

PubMed ID: 16014608

DOI: 10.1091/mbc.e05-01-0081

PubMed ID: 17064668

Title: Multiple Rho proteins regulate the subcellular targeting of PAK5.

PubMed ID: 17064668

DOI: 10.1016/j.bbrc.2006.09.172

PubMed ID: 16581795

Title: Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties.

PubMed ID: 16581795

DOI: 10.1128/mcb.26.8.3215-3230.2006

PubMed ID: 18465753

Title: p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.

PubMed ID: 18465753

DOI: 10.1002/jcb.21809

PubMed ID: 20564219

Title: p120-catenin is a binding partner and substrate for Group B Pak kinases.

PubMed ID: 20564219

DOI: 10.1002/jcb.22639

PubMed ID: 17292838

Title: Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.

PubMed ID: 17292838

DOI: 10.1016/j.str.2007.01.001

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 719
  • Mass: 80745
  • Checksum: 07A12B1EEC4E2A02
  • Sequence:
  • MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 
    PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGPGHA 
    EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA 
    YYSEVKPLKS DFARFSADYH SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA 
    GTSGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQEPMMPFG 
    ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 
    QSKSGYSSSS HQYPSGYHKA TLYHHPSLQS SSQYISTASY LSSLSLSSST YPPPSWGSSS 
    DQQPSRVSHE QFRAALQLVV SPGDPREYLA NFIKIGEGST GIVCIATEKH TGKQVAVKKM 
    DLRKQQRREL LFNEVVIMRD YHHDNVVDMY SSYLVGDELW VVMEFLEGGA LTDIVTHTRM 
    NEEQIATVCL SVLRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 
    KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 
    PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH

Genular Protein ID: 3096774631

Symbol: B0AZM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 719
  • Mass: 80729
  • Checksum: 50C306B2F6954C30
  • Sequence:
  • MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 
    PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGPGHA 
    EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA 
    YYSEVKPLKS DFARFSADYH SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA 
    GTSGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQEPMMPFG 
    ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 
    QSKSGYSSSS HQYPSGYHKA TLYHHPSLQS SSQYISTASY LSSLSLSSST YPPPSWGSSS 
    DQQPSRVSHE QFRAALQLVV SPGDPREYLA NFIKIGEGST GIVCIATEKH TGKQVAVKKM 
    DLRKQQRREL LFNEVVIMRD YHHDNVVDMY SSYLVGDELW VVMEFLEGGA LTDIVTHTRM 
    NEEQIATVCL SVPRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 
    KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 
    PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.