SMURF1 | ENSG00000198742 | NCBI 57154

Details for: SMURF1

Gene ID: 57154

Symbol: SMURF1

Ensembl ID: ENSG00000198742

Description: SMAD specific E3 ubiquitin protein ligase 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Asymmetric localization of pcp proteins
(R-HSA-4608870)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Downregulation of tgf-beta receptor signaling
(R-HSA-2173788)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hedgehog 'on' state
(R-HSA-5632684)
Immune system
(R-HSA-168256)
Pcp/ce pathway
(R-HSA-4086400)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Regulation of runx3 expression and activity
(R-HSA-8941858)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by bmp
(R-HSA-201451)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-HSA-2173791)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Activin receptor binding
(GO:0070697)
Axon
(GO:0030424)
Bmp signaling pathway
(GO:0030509)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Ectoderm development
(GO:0007398)
Engulfment of target by autophagosome
(GO:0061736)
Extracellular exosome
(GO:0070062)
I-smad binding
(GO:0070411)
Mitochondrion
(GO:0005739)
Negative regulation of activin receptor signaling pathway
(GO:0032926)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of dendrite extension
(GO:1903861)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Protein localization to plasma membrane
(GO:0072659)
Protein polyubiquitination
(GO:0000209)
Protein targeting to vacuole involved in autophagy
(GO:0071211)
Protein ubiquitination
(GO:0016567)
R-smad binding
(GO:0070412)
Receptor catabolic process
(GO:0032801)
Smad binding
(GO:0046332)
Substrate localization to autophagosome
(GO:0061753)
Transforming growth factor beta receptor binding
(GO:0005160)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)

Other Information

Proteins

E3 ubiquitin-protein ligase SMURF1

Genular Protein ID: 1579268167

Symbol: SMUF1_HUMAN

Name: E3 ubiquitin-protein ligase SMURF1

UniProtKB Accession Codes:

Q9HCE7 A4D279 B7ZMB6 B9EGV3 O75853 Q547Q3 Q9UJT8

Database IDs:

Citations:

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10458166

Title: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.

PubMed ID: 10458166

DOI: 10.1038/23293

PubMed ID: 11163210

Title: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation.

PubMed ID: 11163210

DOI: 10.1016/s1097-2765(00)00134-9

PubMed ID: 19937093

Title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.

PubMed ID: 19937093

DOI: 10.1007/s11010-009-0315-y

PubMed ID: 21572392

Title: SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

PubMed ID: 21572392

DOI: 10.1038/emboj.2011.155

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 23087404

Title: Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.

PubMed ID: 23087404

DOI: 10.4049/jimmunol.1201445

PubMed ID: 23999003

Title: SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.

PubMed ID: 23999003

DOI: 10.1016/j.jdermsci.2013.07.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21402695

Title: Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.

PubMed ID: 21402695

DOI: 10.1074/jbc.m110.211979

Sequence Information:

Length: 757
Mass: 86114
Checksum: 89A171CFC47B40E9
Sequence:

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 
LNPSDTDAVR GQIVVSLQTR DRIGTGGSVV DCRGLLENEG TVYEDSGPGR PLSCFMEEPA 
PYTDSTGAAA GGGNCRFVES PSQDQRLQAQ RLRNPDVRGS LQTPQNRPHG HQSPELPEGY 
EQRTTVQGQV YFLHTQTGVS TWHDPRIPSP SGTIPGGDAA FLYEFLLQGH TSEPRDLNSV 
NCDELGPLPP GWEVRSTVSG RIYFVDHNNR TTQFTDPRLH HIMNHQCQLK EPSQPLPLPS 
EGSLEDEELP AQRYERDLVQ KLKVLRHELS LQQPQAGHCR IEVSREEIFE ESYRQIMKMR 
PKDLKKRLMV KFRGEEGLDY GGVAREWLYL LCHEMLNPYY GLFQYSTDNI YMLQINPDSS 
INPDHLSYFH FVGRIMGLAV FHGHYINGGF TVPFYKQLLG KPIQLSDLES VDPELHKSLV 
WILENDITPV LDHTFCVEHN AFGRILQHEL KPNGRNVPVT EENKKEYVRL YVNWRFMRGI 
EAQFLALQKG FNELIPQHLL KPFDQKELEL IIGGLDKIDL NDWKSNTRLK HCVADSNIVR 
WFWQAVETFD EERRARLLQF VTGSTRVPLQ GFKALQGSTG AAGPRLFTIH LIDANTDNLP 
KAHTCFNRID IPPYESYEKL YEKLLTAVEE TCGFAVE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SMURF1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10997877

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. PubMed ID: 10458166

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation. PubMed ID: 11163210

Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. PubMed ID: 19937093

SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. PubMed ID: 21572392

TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. PubMed ID: 21791611

Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation. PubMed ID: 23087404

SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. PubMed ID: 23999003

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection. PubMed ID: 21402695