Details for: JPH2

Gene ID: 57158

Symbol: JPH2

Ensembl ID: ENSG00000149596

Description: junctophilin 2

Associated with

Other Information

Genular Protein ID: 2771446847

Symbol: JPH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 10891348

Title: Characterization of human junctophilin subtype genes.

PubMed ID: 10891348

DOI: 10.1006/bbrc.2000.3011

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20095964

Title: S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.

PubMed ID: 20095964

DOI: 10.1042/bj20091225

PubMed ID: 24001019

Title: Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response.

PubMed ID: 24001019

DOI: 10.1042/bj20130591

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30409805

Title: E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator.

PubMed ID: 30409805

DOI: 10.1126/science.aan3303

PubMed ID: 35044787

Title: Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.

PubMed ID: 35044787

DOI: 10.1126/scitranslmed.abf3274

PubMed ID: 17476457

Title: Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy.

PubMed ID: 17476457

DOI: 10.1007/s10038-007-0149-y

PubMed ID: 17509612

Title: Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.

PubMed ID: 17509612

DOI: 10.1016/j.yjmcc.2007.04.006

PubMed ID: 23973696

Title: Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.

PubMed ID: 23973696

DOI: 10.1016/j.jacc.2013.06.052

PubMed ID: 27471098

Title: Mutation in JPH2 cause dilated cardiomyopathy.

PubMed ID: 27471098

DOI: 10.1111/cge.12825

PubMed ID: 27532831

Title: Genetic misdiagnoses and the motential for mealth misparities.

PubMed ID: 27532831

DOI: 10.1056/nejmsa1507092

PubMed ID: 28393127

Title: Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction.

PubMed ID: 28393127

DOI: 10.1016/j.jacbts.2016.11.004

PubMed ID: 30235249

Title: Heterozygous junctophilin-2 (JPH2) p.(Thr161Lys) is a monogenic cause for HCM with heart failure.

PubMed ID: 30235249

DOI: 10.1371/journal.pone.0203422

PubMed ID: 30384889

Title: Genetic basis of severe childhood-onset cardiomyopathies.

PubMed ID: 30384889

DOI: 10.1016/j.jacc.2018.08.2171

PubMed ID: 31227780

Title: Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy.

PubMed ID: 31227780

DOI: 10.1038/s41598-019-44987-6

Sequence Information:

  • Length: 696
  • Mass: 74222
  • Checksum: 80D62652CE48548B
  • Sequence:
  • MSGGRFDFDD GGAYCGGWEG GKAHGHGLCT GPKGQGEYSG SWNFGFEVAG VYTWPSGNTF 
    EGYWSQGKRH GLGIETKGRW LYKGEWTHGF KGRYGIRQSS SSGAKYEGTW NNGLQDGYGT 
    ETYADGGTYQ GQFTNGMRHG YGVRQSVPYG MAVVVRSPLR TSLSSLRSEH SNGTVAPDSP 
    ASPASDGPAL PSPAIPRGGF ALSLLANAEA AARAPKGGGL FQRGALLGKL RRAESRTSVG 
    SQRSRVSFLK SDLSSGASDA ASTASLGEAA EGADEAAPFE ADIDATTTET YMGEWKNDKR 
    SGFGVSERSS GLRYEGEWLD NLRHGYGCTT LPDGHREEGK YRHNVLVKDT KRRMLQLKSN 
    KVRQKVEHSV EGAQRAAAIA RQKAEIAASR TSHAKAKAEA AEQAALAANQ ESNIARTLAR 
    ELAPDFYQPG PEYQKRRLLQ EILENSESLL EPPDRGAGAA GLPQPPRESP QLHERETPRP 
    EGGSPSPAGT PPQPKRPRPG VSKDGLLSPG AWNGEPSGEG SRSVTPSEGA GRRSPARPAT 
    ERMAIEALQA PPAPSREPEV ALYQGYHSYA VRTTPPEPPP FEDQPEPEVS GSESAPSSPA 
    TAPLQAPTLR GPEPARETPA KLEPKPIIPK AEPRAKARKT EARGLTKAGA KKKARKEAAL 
    AAEAEVEVEE VPNTILICMV ILLNIGLAIL FVHLLT

Genular Protein ID: 2703469473

Symbol: Q86VZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 417
  • Mass: 45112
  • Checksum: CD967E60268BFEEB
  • Sequence:
  • EADIDATTTE TYMGEWKNDK RSGFGVSERS SGLRYEGEWL DNLRHGYGCT TLPDGHREEG 
    KYRHNVLVKD TKRRMLQLKS NKVRQKVEHS VEGAQRAAAI ARQKAEIAAS RTSHAKAKAE 
    AAEQAALAAN QESNIARTLA RELAPDFYQP GPEYQKRRLL QEILENSESL LEPPDRGAGA 
    AGLPQPPRES PQLHERETPR PEGGSPSPAG TPPQPKRPRP GVSKDGLLSP GAWNGEPSGE 
    GSRSVTPSEG AGRRSPARPA TERMAIEALQ APPAPSREPE VALYQGYHSY AVRTTPPEPP 
    PFEDQPEPEV SGSESAPSSP ATAPLQAPTL RGPEPARETP AKLEPKPIIP KAEPRAKARK 
    TEARGLTKAG AKKKARKEAA LAAEAEVEVE EVPNTILICM VILLNIGLAI LFVHLLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.