PELI2 | ENSG00000139946 | NCBI 57161

Details for: PELI2

Gene ID: 57161

Symbol: PELI2

Ensembl ID: ENSG00000139946

Description: pellino E3 ubiquitin protein ligase family member 2

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Irak1 recruits ikk complex
(R-HSA-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-HSA-975144)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Signaling by interleukins
(R-HSA-449147)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Cytosol
(GO:0005829)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Regulation of toll signaling pathway
(GO:0008592)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase pellino homolog 2
Q9H716_HUMAN

Genular Protein ID: 1189979408

Symbol: PELI2_HUMAN

Name: E3 ubiquitin-protein ligase pellino homolog 2

UniProtKB Accession Codes:

Q9HAT8 B2RDY5

Database IDs:

Citations:

PubMed ID: 11306823

Title: Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping.

PubMed ID: 11306823

DOI: 10.1159/000056895

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12804775

Title: Pellino2 activates the mitogen activated protein kinase pathway.

PubMed ID: 12804775

DOI: 10.1016/s0014-5793(03)00533-7

PubMed ID: 12860405

Title: Characterization of Pellino2, a substrate of IRAK1 and IRAK4.

PubMed ID: 12860405

DOI: 10.1016/s0014-5793(03)00697-5

PubMed ID: 17675297

Title: Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.

PubMed ID: 17675297

DOI: 10.1074/jbc.m704558200

PubMed ID: 17997719

Title: The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

PubMed ID: 17997719

DOI: 10.1042/bj20071365

PubMed ID: 22669975

Title: Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control.

PubMed ID: 22669975

DOI: 10.1074/jbc.m112.352625

PubMed ID: 19081057

Title: Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.

PubMed ID: 19081057

DOI: 10.1016/j.str.2008.09.011

Sequence Information:

Length: 420
Mass: 46435
Checksum: 2FC5E661C13BC11A
Sequence:

MFSPGQEEHC APNKEPVKYG ELVVLGYNGA LPNGDRGRRK SRFALYKRPK ANGVKPSTVH 
VISTPQASKA ISCKGQHSIS YTLSRNQTVV VEYTHDKDTD MFQVGRSTES PIDFVVTDTI 
SGSQNTDEAQ ITQSTISRFA CRIVCDRNEP YTARIFAAGF DSSKNIFLGE KAAKWKNPDG 
HMDGLTTNGV LVMHPRGGFT EESQPGVWRE ISVCGDVYTL RETRSAQQRG KLVESETNVL 
QDGSLIDLCG ATLLWRTADG LFHTPTQKHI EALRQEINAA RPQCPVGLNT LAFPSINRKE 
VVEEKQPWAY LSCGHVHGYH NWGHRSDTEA NERECPMCRT VGPYVPLWLG CEAGFYVDAG 
PPTHAFTPCG HVCSEKSAKY WSQIPLPHGT HAFHAACPFC ATQLVGEQNC IKLIFQGPID

Genular Protein ID: 512294680

Symbol: Q9H716_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H716

Database IDs:

Sequence Information:

Length: 131
Mass: 14677
Checksum: 51D89A3990B35C4E
Sequence:

MSCHHFKGLA PLPHVYTQGN CRPISCLGLT LMPFASSFPE VKVPVMYSHR NIFQLFMSFT 
TKKKIQSGWS TTLSIFLVRN FLLIIGAAGS CMLQLSTFPL FGSAFSKKGY SSPCRVLRFL 
DFFLPTVAQK N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PELI2

Associated with

Other Information

Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. PubMed ID: 11306823

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Pellino2 activates the mitogen activated protein kinase pathway. PubMed ID: 12804775

Characterization of Pellino2, a substrate of IRAK1 and IRAK4. PubMed ID: 12860405

Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. PubMed ID: 17675297

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. PubMed ID: 17997719

Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control. PubMed ID: 22669975

Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. PubMed ID: 19081057