PELI1 | ENSG00000197329 | NCBI 57162

Details for: PELI1

Gene ID: 57162

Symbol: PELI1

Ensembl ID: ENSG00000197329

Description: pellino E3 ubiquitin protein ligase 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Irak1 recruits ikk complex
(R-HSA-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-HSA-975144)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Signaling by interleukins
(R-HSA-449147)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Cytosol
(GO:0005829)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of t cell proliferation
(GO:0042130)
Nucleus
(GO:0005634)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of toll-like receptor 3 signaling pathway
(GO:0034141)
Positive regulation of toll-like receptor 4 signaling pathway
(GO:0034145)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Regulation of necroptotic process
(GO:0060544)
Regulation of toll signaling pathway
(GO:0008592)
Response to dsrna
(GO:0043331)
Response to lipopolysaccharide
(GO:0032496)
T cell proliferation
(GO:0042098)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase pellino homolog 1

Genular Protein ID: 3103631977

Symbol: PELI1_HUMAN

Name: E3 ubiquitin-protein ligase pellino homolog 1

UniProtKB Accession Codes:

Q96FA3 Q96SM0 Q9GZY5 Q9HCX0

Database IDs:

Citations:

PubMed ID: 11132151

Title: Pellino-related sequences from Caenorhabditis elegans and Homo sapiens.

PubMed ID: 11132151

DOI: 10.1007/s002510000249

PubMed ID: 11306823

Title: Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping.

PubMed ID: 11306823

DOI: 10.1159/000056895

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12496252

Title: Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.

PubMed ID: 12496252

DOI: 10.1074/jbc.m212112200

PubMed ID: 12804775

Title: Pellino2 activates the mitogen activated protein kinase pathway.

PubMed ID: 12804775

DOI: 10.1016/s0014-5793(03)00533-7

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 17675297

Title: Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.

PubMed ID: 17675297

DOI: 10.1074/jbc.m704558200

PubMed ID: 17997719

Title: The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

PubMed ID: 17997719

DOI: 10.1042/bj20071365

PubMed ID: 21120624

Title: Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9.

PubMed ID: 21120624

DOI: 10.1007/s10059-011-0006-x

PubMed ID: 29883609

Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

PubMed ID: 29883609

DOI: 10.1016/j.molcel.2018.05.016

Sequence Information:

Length: 418
Mass: 46286
Checksum: 233318A45E7546F7
Sequence:

MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA 
CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG 
SQSNSDTQSV QSTISRFACR IICERNPPFT ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM 
DGLTTNGVLV MHPRNGFTED SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD 
GSLIDLCGAT LLWRTAEGLS HTPTVKHLEA LRQEINAARP QCPVGFNTLA FPSMKRKDVV 
DEKQPWVYLN CGHVHGYHNW GNKEERDGKD RECPMCRSVG PYVPLWLGCE AGFYVDAGPP 
THAFSPCGHV CSEKTTAYWS QIPLPHGTHT FHAACPFCAH QLAGEQGYIR LIFQGPLD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PELI1

Associated with

Other Information

Pellino-related sequences from Caenorhabditis elegans and Homo sapiens. PubMed ID: 11132151

Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. PubMed ID: 11306823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. PubMed ID: 12496252

Pellino2 activates the mitogen activated protein kinase pathway. PubMed ID: 12804775

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. PubMed ID: 17675297

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. PubMed ID: 17997719

Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9. PubMed ID: 21120624

PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation. PubMed ID: 29883609