SALL4 | ENSG00000101115 | NCBI 57167

Details for: SALL4

Gene ID: 57167

Symbol: SALL4

Ensembl ID: ENSG00000101115

Description: spalt like transcription factor 4

Associated with

Developmental biology
(R-HSA-1266738)
Intracellular signaling by second messengers
(R-HSA-9006925)
Pip3 activates akt signaling
(R-HSA-1257604)
Pou5f1 (oct4), sox2, nanog activate genes related to proliferation
(R-HSA-2892247)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Signal transduction
(R-HSA-162582)
Transcriptional regulation of pluripotent stem cells
(R-HSA-452723)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Embryonic limb morphogenesis
(GO:0030326)
Heterochromatin
(GO:0000792)
Inner cell mass cell proliferation
(GO:0001833)
Intracellular membrane-bounded organelle
(GO:0043231)
Metal ion binding
(GO:0046872)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Somatic stem cell population maintenance
(GO:0035019)
Ventricular septum development
(GO:0003281)

Other Information

Proteins

Sal-like protein 4

Genular Protein ID: 462560864

Symbol: SALL4_HUMAN

Name: Sal-like protein 4

UniProtKB Accession Codes:

Q9UJQ4 A2A2D8 Q540H3 Q6Y8G6

Database IDs:

Citations:

PubMed ID: 16763212

Title: SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.

PubMed ID: 16763212

DOI: 10.1182/blood-2006-02-001594

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12393809

Title: Okihiro syndrome is caused by SALL4 mutations.

PubMed ID: 12393809

DOI: 10.1093/hmg/11.23.2979

PubMed ID: 16545361

Title: The vertebrate spalt genes in development and disease.

PubMed ID: 16545361

DOI: 10.1016/j.ydbio.2006.02.009

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21914818

Title: A BEN-domain-containing protein associates with heterochromatin and represses transcription.

PubMed ID: 21914818

DOI: 10.1242/jcs.086603

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 23012367

Title: Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.

PubMed ID: 23012367

DOI: 10.1074/jbc.m112.391441

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12395297

Title: Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family.

PubMed ID: 12395297

DOI: 10.1086/343821

PubMed ID: 16402211

Title: A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial midline defects and mild features of Okihiro syndrome.

PubMed ID: 16402211

DOI: 10.1007/s00439-005-0124-7

PubMed ID: 17256792

Title: IVIC syndrome is caused by a c.2607delA mutation in the SALL4 locus.

PubMed ID: 17256792

DOI: 10.1002/ajmg.a.31603

Sequence Information:

Length: 1053
Mass: 112231
Checksum: 61D0D1F21CB2B337
Sequence:

MSRRKQAKPQ HINSEEDQGE QQPQQQTPEF ADAAPAAPAA GELGAPVNHP GNDEVASEDE 
ATVKRLRREE THVCEKCCAE FFSISEFLEH KKNCTKNPPV LIMNDSEGPV PSEDFSGAVL 
SHQPTSPGSK DCHRENGGSS EDMKEKPDAE SVVYLKTETA LPPTPQDISY LAKGKVANTN 
VTLQALRGTK VAVNQRSADA LPAPVPGANS IPWVLEQILC LQQQQLQQIQ LTEQIRIQVN 
MWASHALHSS GAGADTLKTL GSHMSQQVSA AVALLSQKAG SQGLSLDALK QAKLPHANIP 
SATSSLSPGL APFTLKPDGT RVLPNVMSRL PSALLPQAPG SVLFQSPFST VALDTSKKGK 
GKPPNISAVD VKPKDEAALY KHKCKYCSKV FGTDSSLQIH LRSHTGERPF VCSVCGHRFT 
TKGNLKVHFH RHPQVKANPQ LFAEFQDKVA AGNGIPYALS VPDPIDEPSL SLDSKPVLVT 
TSVGLPQNLS SGTNPKDLTG GSLPGDLQPG PSPESEGGPT LPGVGPNYNS PRAGGFQGSG 
TPEPGSETLK LQQLVENIDK ATTDPNECLI CHRVLSCQSS LKMHYRTHTG ERPFQCKICG 
RAFSTKGNLK THLGVHRTNT SIKTQHSCPI CQKKFTNAVM LQQHIRMHMG GQIPNTPLPE 
NPCDFTGSEP MTVGENGSTG AICHDDVIES IDVEEVSSQE APSSSSKVPT PLPSIHSASP 
TLGFAMMASL DAPGKVGPAP FNLQRQGSRE NGSVESDGLT NDSSSLMGDQ EYQSRSPDIL 
ETTSFQALSP ANSQAESIKS KSPDAGSKAE SSENSRTEME GRSSLPSTFI RAPPTYVKVE 
VPGTFVGPST LSPGMTPLLA AQPRRQAKQH GCTRCGKNFS SASALQIHER THTGEKPFVC 
NICGRAFTTK GNLKVHYMTH GANNNSARRG RKLAIENTMA LLGTDGKRVS EIFPKEILAP 
SVNVDPVVWN QYTSMLNGGL AVKTNEISVI QSGGVPTLPV SLGATSVVNN ATVSKMDGSQ 
SGISADVEKP SATDGVPKHQ FPHFLEENKI AVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SALL4

Associated with

Other Information

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. PubMed ID: 16763212

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Okihiro syndrome is caused by SALL4 mutations. PubMed ID: 12393809

The vertebrate spalt genes in development and disease. PubMed ID: 16545361

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

A BEN-domain-containing protein associates with heterochromatin and represses transcription. PubMed ID: 21914818

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. PubMed ID: 22510880

Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor. PubMed ID: 23012367

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. PubMed ID: 12395297

A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial midline defects and mild features of Okihiro syndrome. PubMed ID: 16402211

IVIC syndrome is caused by a c.2607delA mutation in the SALL4 locus. PubMed ID: 17256792