Details for: BAD

Gene ID: 572

Symbol: BAD

Ensembl ID: ENSG00000002330

Description: BCL2 associated agonist of cell death

Associated with

  • Activation of bad and translocation to mitochondria
    (R-HSA-111447)
  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Akt phosphorylates targets in the cytosol
    (R-HSA-198323)
  • Apoptosis
    (R-HSA-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-HSA-111453)
  • Cell death signalling via nrage, nrif and nade
    (R-HSA-204998)
  • Constitutive signaling by akt1 e17k in cancer
    (R-HSA-5674400)
  • Death receptor signaling
    (R-HSA-73887)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • Intracellular signaling by second messengers
    (R-HSA-9006925)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Nrage signals death through jnk
    (R-HSA-193648)
  • P75 ntr receptor-mediated signalling
    (R-HSA-193704)
  • Pi3k/akt signaling in cancer
    (R-HSA-2219528)
  • Pip3 activates akt signaling
    (R-HSA-1257604)
  • Programmed cell death
    (R-HSA-5357801)
  • Signal transduction
    (R-HSA-162582)
  • Activation of cysteine-type endopeptidase activity
    (GO:0097202)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Adp metabolic process
    (GO:0046031)
  • Apoptotic process
    (GO:0006915)
  • Atp metabolic process
    (GO:0046034)
  • Bad-bcl-2 complex
    (GO:0097138)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to lipid
    (GO:0071396)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Cellular response to nicotine
    (GO:0071316)
  • Cysteine-type endopeptidase activator activity involved in apoptotic process
    (GO:0008656)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytosol
    (GO:0005829)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Glucose catabolic process
    (GO:0006007)
  • Glucose homeostasis
    (GO:0042593)
  • Intrinsic apoptotic signaling pathway
    (GO:0097193)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Lipid binding
    (GO:0008289)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Phospholipid binding
    (GO:0005543)
  • Pore complex assembly
    (GO:0046931)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of glucokinase activity
    (GO:0033133)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
    (GO:1902220)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of proteolysis
    (GO:0045862)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of type b pancreatic cell development
    (GO:2000078)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphatase binding
    (GO:0019903)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.1
    Marker Score: 13387
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.93
    Marker Score: 8326
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.89
    Marker Score: 7447
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.82
    Marker Score: 4129
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8
    Marker Score: 62447
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.77
    Marker Score: 1984
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.68
    Marker Score: 18956.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.63
    Marker Score: 2624.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.6
    Marker Score: 2542.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.59
    Marker Score: 3317
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.58
    Marker Score: 3213
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.57
    Marker Score: 7553
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.56
    Marker Score: 5762
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.52
    Marker Score: 2516
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.51
    Marker Score: 9874
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.51
    Marker Score: 13019
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.49
    Marker Score: 4677
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.49
    Marker Score: 4043
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.48
    Marker Score: 2585
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.48
    Marker Score: 12841
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.47
    Marker Score: 981
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.46
    Marker Score: 545
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.46
    Marker Score: 9476
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.45
    Marker Score: 1532
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.45
    Marker Score: 606
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.43
    Marker Score: 2108
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.43
    Marker Score: 3365
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.41
    Marker Score: 3560
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.39
    Marker Score: 715
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3131
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.37
    Marker Score: 2325.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.37
    Marker Score: 3576
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.36
    Marker Score: 1301
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.35
    Marker Score: 17868
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.35
    Marker Score: 2854
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.35
    Marker Score: 2209
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.34
    Marker Score: 462
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.34
    Marker Score: 13469.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.33
    Marker Score: 4731.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.32
    Marker Score: 442
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.31
    Marker Score: 622
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.31
    Marker Score: 1357
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.3
    Marker Score: 2440
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.3
    Marker Score: 304
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.28
    Marker Score: 412
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.28
    Marker Score: 705
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.26
    Marker Score: 2393
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.26
    Marker Score: 283
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.25
    Marker Score: 1344
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.24
    Marker Score: 1236.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.22
    Marker Score: 1300
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.22
    Marker Score: 1148
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.21
    Marker Score: 3255.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.21
    Marker Score: 1464
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.21
    Marker Score: 9423
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.2
    Marker Score: 1220
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.2
    Marker Score: 1067
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2
    Marker Score: 7648
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.19
    Marker Score: 1125.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.19
    Marker Score: 808
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.19
    Marker Score: 653
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.18
    Marker Score: 375
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.18
    Marker Score: 582
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.17
    Marker Score: 608
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.17
    Marker Score: 337
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.16
    Marker Score: 973
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.16
    Marker Score: 548
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.16
    Marker Score: 2744.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.15
    Marker Score: 327
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.15
    Marker Score: 1768
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.15
    Marker Score: 681
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.15
    Marker Score: 723
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.14
    Marker Score: 2089
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.14
    Marker Score: 6011
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.14
    Marker Score: 323
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17844.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.13
    Marker Score: 261
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.13
    Marker Score: 413
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.13
    Marker Score: 4630
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.13
    Marker Score: 325
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.13
    Marker Score: 1549
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.12
    Marker Score: 2246
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.12
    Marker Score: 362
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.12
    Marker Score: 2639
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.11
    Marker Score: 1576
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.11
    Marker Score: 1297.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.09
    Marker Score: 1318
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.09
    Marker Score: 370
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.09
    Marker Score: 245
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.09
    Marker Score: 772
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.08
    Marker Score: 375
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.08
    Marker Score: 267
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.08
    Marker Score: 1664
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.08
    Marker Score: 4157
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.08
    Marker Score: 1152
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.08
    Marker Score: 1390
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.07
    Marker Score: 1326
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.07
    Marker Score: 335.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.07
    Marker Score: 1394
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.07
    Marker Score: 702

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Other Information

**Key characteristics:** * BAD is a protein that is found in the cytoplasm of cells. * BAD is a pro-apoptotic protein that can be activated by a variety of cellular signals. * BAD is a key regulator of cell death. **Pathways and functions:** * BAD can activate the mitochondrial apoptosis pathway through the phosphorylation of BAD by the BH3-only proteins Bcl-xL and Bcl-xL2. * BAD can also activate the N-ras GTPase pathway, which leads to the activation of the pro-apoptotic protein Bax. * BAD can also regulate the apoptotic response to growth factors and other stress signals. **Clinical significance:** * BAD is a promising target for cancer therapy. * Inhibition of BAD can prevent the activation of the mitochondrial apoptosis pathway and can lead to cell survival. * Inhibition of BAD has been shown to be effective in preclinical models of cancer. **Additional notes:** * BAD is a ubiquitin ligase that is involved in the regulation of cell death. * BAD is also a key regulator of inflammation. * Mutations in the BAD gene have been linked to a number of human cancers.

Genular Protein ID: 1418302410

Symbol: BAD_HUMAN

Name: Bcl2-associated agonist of cell death

UniProtKB Accession Codes:

Q92934 O14803 Q6FH21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 12 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8929532

Title: Bcl-2 targets the protein kinase Raf-1 to mitochondria.

PubMed ID: 8929532

DOI: 10.1016/s0092-8674(00)81383-5

PubMed ID: 9388232

Title: Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.

PubMed ID: 9388232

DOI: 10.1074/jbc.272.49.30866

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10926925

Title: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.

PubMed ID: 10926925

DOI: 10.1074/jbc.m001753200

PubMed ID: 11278822

Title: The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.

PubMed ID: 11278822

DOI: 10.1074/jbc.m011046200

PubMed ID: 12897128

Title: p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.

PubMed ID: 12897128

DOI: 10.1128/mcb.23.16.5526-5539.2003

PubMed ID: 16818649

Title: Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.

PubMed ID: 16818649

DOI: 10.1158/0008-5472.can-05-4272

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17270021

Title: Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.

PubMed ID: 17270021

DOI: 10.1111/j.1349-7006.2007.00390.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21444773

Title: Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.

PubMed ID: 21444773

DOI: 10.1073/pnas.1015328108

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 11206074

Title: Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

PubMed ID: 11206074

DOI: 10.1110/ps.9.12.2528

Sequence Information:

  • Length: 168
  • Mass: 18392
  • Checksum: 69FD8D27DDEE3241
  • Sequence:
    • MFQIPEFEPS EQEDSSSAER GLGPSPAGDG PSGSGKHHRQ APGLLWDASH QQEQPTSSSH 
HGGAGAVEIR SRHSSYPAGT EDDEGMGEEP SPFRGRSRSA PPNLWAAQRY GRELRRMSDE 
FVDSFKKGLP RPKSAGTATQ MRQSSSWTRV FQSWWDRNLG RGSSAPSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.