BAD | ENSG00000002330 | NCBI 572

Details for: BAD

Gene ID: 572

Symbol: BAD

Ensembl ID: ENSG00000002330

Description: BCL2 associated agonist of cell death

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Apoptosis
(R-HSA-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-HSA-111453)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Death receptor signaling
(R-HSA-73887)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Intracellular signaling by second messengers
(R-HSA-9006925)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Nrage signals death through jnk
(R-HSA-193648)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Programmed cell death
(R-HSA-5357801)
Signal transduction
(R-HSA-162582)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adp metabolic process
(GO:0046031)
Apoptotic process
(GO:0006915)
Atp metabolic process
(GO:0046034)
Bad-bcl-2 complex
(GO:0097138)
Cellular response to hypoxia
(GO:0071456)
Cellular response to lipid
(GO:0071396)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to nicotine
(GO:0071316)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytosol
(GO:0005829)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Glucose catabolic process
(GO:0006007)
Glucose homeostasis
(GO:0042593)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Lipid binding
(GO:0008289)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Phospholipid binding
(GO:0005543)
Pore complex assembly
(GO:0046931)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of b cell differentiation
(GO:0045579)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
(GO:1902220)
Positive regulation of mitochondrial membrane potential
(GO:0010918)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Positive regulation of t cell differentiation
(GO:0045582)
Positive regulation of type b pancreatic cell development
(GO:2000078)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Release of cytochrome c from mitochondria
(GO:0001836)
Type b pancreatic cell proliferation
(GO:0044342)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 198.5918
Cell Significance Index: -30.8900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 134.5196
Cell Significance Index: -34.1200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 86.7783
Cell Significance Index: -40.9700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 76.0519
Cell Significance Index: -39.1200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 61.4883
Cell Significance Index: -41.2600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.6313
Cell Significance Index: -39.0000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.0084
Cell Significance Index: -29.4900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.2457
Cell Significance Index: -40.4300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.2892
Cell Significance Index: -25.4600
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 2.7911
Cell Significance Index: 23.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.0403
Cell Significance Index: 92.4800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.0072
Cell Significance Index: 218.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.9273
Cell Significance Index: 89.8600
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2507
Cell Significance Index: 683.0500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.2390
Cell Significance Index: 170.1600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2353
Cell Significance Index: 1115.3700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1518
Cell Significance Index: 24.1100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0210
Cell Significance Index: 22.1200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9415
Cell Significance Index: 115.7700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.8896
Cell Significance Index: 13.3300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.8869
Cell Significance Index: 113.6900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.8779
Cell Significance Index: 46.1000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.8611
Cell Significance Index: 7.9300
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8543
Cell Significance Index: 22.4700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8450
Cell Significance Index: 53.2600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8395
Cell Significance Index: 43.6100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8387
Cell Significance Index: 151.2000
Cell Name: kidney cell (CL1000497)
Fold Change: 0.7715
Cell Significance Index: 6.1600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7454
Cell Significance Index: 20.2900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7285
Cell Significance Index: 322.1000
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.6967
Cell Significance Index: 5.3700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6848
Cell Significance Index: 47.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5808
Cell Significance Index: 16.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5800
Cell Significance Index: 27.2600
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.5552
Cell Significance Index: 3.4500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5534
Cell Significance Index: 19.2300
Cell Name: peg cell (CL4033014)
Fold Change: 0.5346
Cell Significance Index: 12.3500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5312
Cell Significance Index: 37.5700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5193
Cell Significance Index: 15.2500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4826
Cell Significance Index: 35.9700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4419
Cell Significance Index: 11.8000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4212
Cell Significance Index: 27.1800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.4190
Cell Significance Index: 4.7600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4119
Cell Significance Index: 40.7500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3818
Cell Significance Index: 49.3200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3636
Cell Significance Index: 72.9300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3087
Cell Significance Index: 58.7500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2715
Cell Significance Index: 32.0200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2116
Cell Significance Index: 2.7100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1544
Cell Significance Index: 5.4300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0909
Cell Significance Index: 32.5900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0895
Cell Significance Index: 61.9300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0698
Cell Significance Index: 2.2400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0589
Cell Significance Index: 44.5800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0544
Cell Significance Index: 0.9100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0496
Cell Significance Index: 9.8500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0183
Cell Significance Index: 0.3900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0047
Cell Significance Index: 3.4300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0109
Cell Significance Index: -20.4700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0220
Cell Significance Index: -40.5400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0264
Cell Significance Index: -40.6100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0333
Cell Significance Index: -45.2900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0351
Cell Significance Index: -3.5900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0397
Cell Significance Index: -29.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0470
Cell Significance Index: -29.8600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0637
Cell Significance Index: -35.9300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0637
Cell Significance Index: -10.8900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0731
Cell Significance Index: -33.1900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0785
Cell Significance Index: -49.0200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1034
Cell Significance Index: -29.7400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1238
Cell Significance Index: -14.4300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1417
Cell Significance Index: -3.6200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1474
Cell Significance Index: -4.2300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1746
Cell Significance Index: -4.8800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2132
Cell Significance Index: -24.4300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2236
Cell Significance Index: -47.1000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2352
Cell Significance Index: -34.1900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2646
Cell Significance Index: -3.6100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3372
Cell Significance Index: -26.7100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3476
Cell Significance Index: -23.3700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3814
Cell Significance Index: -23.4500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3852
Cell Significance Index: -40.1100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3924
Cell Significance Index: -30.1100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4391
Cell Significance Index: -7.7600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4794
Cell Significance Index: -14.1200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.4829
Cell Significance Index: -5.2500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5619
Cell Significance Index: -31.5300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5738
Cell Significance Index: -6.8400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5812
Cell Significance Index: -35.6300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6524
Cell Significance Index: -17.4800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6823
Cell Significance Index: -18.2500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7860
Cell Significance Index: -34.7700
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.8308
Cell Significance Index: -5.1400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8663
Cell Significance Index: -31.8000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8759
Cell Significance Index: -15.0100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.8925
Cell Significance Index: -18.5200
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.9018
Cell Significance Index: -14.8600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.9212
Cell Significance Index: -32.2700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9216
Cell Significance Index: -34.9000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9317
Cell Significance Index: -23.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** * BAD is a pro-apoptotic protein that promotes cell death by interacting with anti-apoptotic BCL-2 family members. * BAD is induced by BAX and translocates to the mitochondria, where it interacts with anti-apoptotic BCL-2 family members. * BAD's interaction with anti-apoptotic BCL-2 family members leads to their inactivation and promotes cell death. * BAD is involved in various cellular processes, including apoptosis, autophagy, and cellular response to hypoxia. * BAD is expressed in various cell types, including neurons, epithelial cells, and stromal cells. **Pathways and Functions:** * **Activation of BAD and translocation to mitochondria:** BAD is induced by BAX and translocates to the mitochondria, where it interacts with anti-apoptotic BCL-2 family members. * **Activation of BAX:** BAD's interaction with anti-apoptotic BCL-2 family members leads to their inactivation and promotes cell death. * **Activation of cysteine-type endopeptidase activity:** BAD's interaction with anti-apoptotic BCL-2 family members leads to the activation of cysteine-type endopeptidase activity, which promotes cell death. * **Activation of Akt phosphorylation:** BAD's interaction with anti-apoptotic BCL-2 family members leads to the activation of Akt phosphorylation, which promotes cell survival. * **Apoptosis:** BAD's interaction with anti-apoptotic BCL-2 family members leads to the promotion of apoptosis, a process of programmed cell death. **Clinical Significance:** * **Cancer:** BAD's pro-apoptotic function is critical for preventing cancer. Mutations in the BAD gene have been implicated in various types of cancer, including breast, lung, and colon cancer. * **Neurodegenerative diseases:** BAD's pro-apoptotic function is critical for maintaining neuronal health. Mutations in the BAD gene have been implicated in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. * **Cardiovascular disease:** BAD's pro-apoptotic function is critical for maintaining cardiac health. Mutations in the BAD gene have been implicated in various cardiovascular diseases, including heart failure and myocardial infarction. * **Inflammatory diseases:** BAD's pro-apoptotic function is critical for maintaining immune homeostasis. Mutations in the BAD gene have been implicated in various inflammatory diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, the BAD gene plays a critical role in regulating cell death and survival, and its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, cardiovascular disease, and inflammatory diseases. Further research is needed to fully understand the mechanisms of BAD's pro-apoptotic function and its role in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Bcl2-associated agonist of cell death

Genular Protein ID: 1418302410

Symbol: BAD_HUMAN

Name: Bcl2-associated agonist of cell death

UniProtKB Accession Codes:

Q92934 O14803 Q6FH21

Database IDs:

Citations:

PubMed ID: 8929532

Title: Bcl-2 targets the protein kinase Raf-1 to mitochondria.

PubMed ID: 8929532

DOI: 10.1016/s0092-8674(00)81383-5

PubMed ID: 9388232

Title: Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.

PubMed ID: 9388232

DOI: 10.1074/jbc.272.49.30866

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10926925

Title: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.

PubMed ID: 10926925

DOI: 10.1074/jbc.m001753200

PubMed ID: 11278822

Title: The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.

PubMed ID: 11278822

DOI: 10.1074/jbc.m011046200

PubMed ID: 12897128

Title: p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.

PubMed ID: 12897128

DOI: 10.1128/mcb.23.16.5526-5539.2003

PubMed ID: 16818649

Title: Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.

PubMed ID: 16818649

DOI: 10.1158/0008-5472.can-05-4272

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17270021

Title: Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.

PubMed ID: 17270021

DOI: 10.1111/j.1349-7006.2007.00390.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21444773

Title: Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.

PubMed ID: 21444773

DOI: 10.1073/pnas.1015328108

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 11206074

Title: Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

PubMed ID: 11206074

DOI: 10.1110/ps.9.12.2528

Sequence Information:

Length: 168
Mass: 18392
Checksum: 69FD8D27DDEE3241
Sequence:

MFQIPEFEPS EQEDSSSAER GLGPSPAGDG PSGSGKHHRQ APGLLWDASH QQEQPTSSSH 
HGGAGAVEIR SRHSSYPAGT EDDEGMGEEP SPFRGRSRSA PPNLWAAQRY GRELRRMSDE 
FVDSFKKGLP RPKSAGTATQ MRQSSSWTRV FQSWWDRNLG RGSSAPSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BAD

Associated with

Cells (max top 100)

Other Information

Bcl-2 targets the protein kinase Raf-1 to mitochondria. PubMed ID: 8929532

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. PubMed ID: 9388232

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage. PubMed ID: 10926925

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. PubMed ID: 11278822

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. PubMed ID: 12897128

Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. PubMed ID: 16818649

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. PubMed ID: 17270021

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. PubMed ID: 21444773

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. PubMed ID: 11206074