Details for: BAD

Gene ID: 572

Symbol: BAD

Ensembl ID: ENSG00000002330

Description: BCL2 associated agonist of cell death

Associated with

  • Activation of bad and translocation to mitochondria
    (R-HSA-111447)
  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Akt phosphorylates targets in the cytosol
    (R-HSA-198323)
  • Apoptosis
    (R-HSA-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-HSA-111453)
  • Cell death signalling via nrage, nrif and nade
    (R-HSA-204998)
  • Constitutive signaling by akt1 e17k in cancer
    (R-HSA-5674400)
  • Death receptor signaling
    (R-HSA-73887)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • Intracellular signaling by second messengers
    (R-HSA-9006925)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Nrage signals death through jnk
    (R-HSA-193648)
  • P75 ntr receptor-mediated signalling
    (R-HSA-193704)
  • Pi3k/akt signaling in cancer
    (R-HSA-2219528)
  • Pip3 activates akt signaling
    (R-HSA-1257604)
  • Programmed cell death
    (R-HSA-5357801)
  • Signal transduction
    (R-HSA-162582)
  • Activation of cysteine-type endopeptidase activity
    (GO:0097202)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Adp metabolic process
    (GO:0046031)
  • Apoptotic process
    (GO:0006915)
  • Atp metabolic process
    (GO:0046034)
  • Bad-bcl-2 complex
    (GO:0097138)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to lipid
    (GO:0071396)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Cellular response to nicotine
    (GO:0071316)
  • Cysteine-type endopeptidase activator activity involved in apoptotic process
    (GO:0008656)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytosol
    (GO:0005829)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Glucose catabolic process
    (GO:0006007)
  • Glucose homeostasis
    (GO:0042593)
  • Intrinsic apoptotic signaling pathway
    (GO:0097193)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Lipid binding
    (GO:0008289)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Phospholipid binding
    (GO:0005543)
  • Pore complex assembly
    (GO:0046931)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of glucokinase activity
    (GO:0033133)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
    (GO:1902220)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of proteolysis
    (GO:0045862)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of type b pancreatic cell development
    (GO:2000078)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphatase binding
    (GO:0019903)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Other Information

Genular Protein ID: 1418302410

Symbol: BAD_HUMAN

Name: Bcl2-associated agonist of cell death

UniProtKB Accession Codes:

Q92934 O14803 Q6FH21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 12 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8929532

Title: Bcl-2 targets the protein kinase Raf-1 to mitochondria.

PubMed ID: 8929532

DOI: 10.1016/s0092-8674(00)81383-5

PubMed ID: 9388232

Title: Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.

PubMed ID: 9388232

DOI: 10.1074/jbc.272.49.30866

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10926925

Title: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.

PubMed ID: 10926925

DOI: 10.1074/jbc.m001753200

PubMed ID: 11278822

Title: The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.

PubMed ID: 11278822

DOI: 10.1074/jbc.m011046200

PubMed ID: 12897128

Title: p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.

PubMed ID: 12897128

DOI: 10.1128/mcb.23.16.5526-5539.2003

PubMed ID: 16818649

Title: Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.

PubMed ID: 16818649

DOI: 10.1158/0008-5472.can-05-4272

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17270021

Title: Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.

PubMed ID: 17270021

DOI: 10.1111/j.1349-7006.2007.00390.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21444773

Title: Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.

PubMed ID: 21444773

DOI: 10.1073/pnas.1015328108

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 11206074

Title: Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

PubMed ID: 11206074

DOI: 10.1110/ps.9.12.2528

Sequence Information:

  • Length: 168
  • Mass: 18392
  • Checksum: 69FD8D27DDEE3241
  • Sequence:
    • MFQIPEFEPS EQEDSSSAER GLGPSPAGDG PSGSGKHHRQ APGLLWDASH QQEQPTSSSH 
HGGAGAVEIR SRHSSYPAGT EDDEGMGEEP SPFRGRSRSA PPNLWAAQRY GRELRRMSDE 
FVDSFKKGLP RPKSAGTATQ MRQSSSWTRV FQSWWDRNLG RGSSAPSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.