CEMIP | ENSG00000103888 | NCBI 57214

Details for: CEMIP

Gene ID: 57214

Symbol: CEMIP

Ensembl ID: ENSG00000103888

Description: cell migration inducing hyaluronidase 1

Associated with

Glycosaminoglycan metabolism
(R-HSA-1630316)
Hyaluronan biosynthesis and export
(R-HSA-2142850)
Hyaluronan metabolism
(R-HSA-2142845)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Carbohydrate binding
(GO:0030246)
Clathrin-coated endocytic vesicle
(GO:0045334)
Clathrin-coated pit
(GO:0005905)
Clathrin-coated vesicle membrane
(GO:0030665)
Clathrin heavy chain binding
(GO:0032050)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Er retention sequence binding
(GO:0046923)
Extracellular region
(GO:0005576)
Fibrillar center
(GO:0001650)
Hyaluronan biosynthetic process
(GO:0030213)
Hyaluronan catabolic process
(GO:0030214)
Hyaluronic acid binding
(GO:0005540)
Hyalurononglucosaminidase activity
(GO:0004415)
Nuclear membrane
(GO:0031965)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein kinase c activity
(GO:1900020)
Positive regulation of protein targeting to membrane
(GO:0090314)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Protein binding
(GO:0005515)
Sensory perception of sound
(GO:0007605)

Other Information

Proteins

Cell migration-inducing and hyaluronan-binding protein

Genular Protein ID: 241734082

Symbol: CEMIP_HUMAN

Name: Cell migration-inducing and hyaluronan-binding protein

UniProtKB Accession Codes:

Q8WUJ3 Q6L9J5 Q9H1K5 Q9NPN9 Q9ULM1

Database IDs:

Citations:

PubMed ID: 14577002

Title: Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss.

PubMed ID: 14577002

DOI: 10.1007/s10038-003-0079-2

PubMed ID: 16157444

Title: Upregulation of the KIAA1199 gene is associated with cellular mortality.

PubMed ID: 16157444

DOI: 10.1016/j.canlet.2005.07.028

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 11247670

Title: Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.

PubMed ID: 11247670

DOI: 10.1006/geno.2000.6466

PubMed ID: 12471561

Title: Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues.

PubMed ID: 12471561

DOI: 10.1086/345398

PubMed ID: 19434458

Title: Clinicopathologic significance of KIAA1199 overexpression in human gastric cancer.

PubMed ID: 19434458

DOI: 10.1245/s10434-009-0469-6

PubMed ID: 21772334

Title: Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.

PubMed ID: 21772334

DOI: 10.1038/bjc.2011.268

PubMed ID: 22970280

Title: Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer.

PubMed ID: 22970280

DOI: 10.1371/journal.pone.0044661

PubMed ID: 23990668

Title: Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.

PubMed ID: 23990668

DOI: 10.1093/jnci/djt224

PubMed ID: 23936024

Title: Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors.

PubMed ID: 23936024

DOI: 10.1371/journal.pone.0069473

PubMed ID: 23509262

Title: KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization.

PubMed ID: 23509262

DOI: 10.1073/pnas.1215432110

PubMed ID: 24269685

Title: N-Terminal signal sequence is required for cellular trafficking and hyaluronan-depolymerization of KIAA1199.

PubMed ID: 24269685

DOI: 10.1016/j.febslet.2013.11.017

Sequence Information:

Length: 1361
Mass: 152998
Checksum: 40CDFFB84F99516C
Sequence:

MGAAGRQDFL FKAMLTISWL TLTCFPGATS TVAAGCPDQS PELQPWNPGH DQDHHVHIGQ 
GKTLLLTSSA TVYSIHISEG GKLVIKDHDE PIVLRTRHIL IDNGGELHAG SALCPFQGNF 
TIILYGRADE GIQPDPYYGL KYIGVGKGGA LELHGQKKLS WTFLNKTLHP GGMAEGGYFF 
ERSWGHRGVI VHVIDPKSGT VIHSDRFDTY RSKKESERLV QYLNAVPDGR ILSVAVNDEG 
SRNLDDMARK AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVF 
KLFQTEHGEY FNVSLSSEWV QDVEWTEWFD HDKVSQTKGG EKISDLWKAH PGKICNRPID 
IQATTMDGVN LSTEVVYKKG QDYRFACYDR GRACRSYRVR FLCGKPVRPK LTVTIDTNVN 
STILNLEDNV QSWKPGDTLV IASTDYSMYQ AEEFQVLPCR SCAPNQVKVA GKPMYLHIGE 
EIDGVDMRAE VGLLSRNIIV MGEMEDKCYP YRNHICNFFD FDTFGGHIKF ALGFKAAHLE 
GTELKHMGQQ LVGQYPIHFH LAGDVDERGG YDPPTYIRDL SIHHTFSRCV TVHGSNGLLI 
KDVVGYNSLG HCFFTEDGPE ERNTFDHCLG LLVKSGTLLP SDRDSKMCKM ITEDSYPGYI 
PKPRQDCNAV STFWMANPNN NLINCAAAGS EETGFWFIFH HVPTGPSVGM YSPGYSEHIP 
LGKFYNNRAH SNYRAGMIID NGVKTTEASA KDKRPFLSII SARYSPHQDA DPLKPREPAI 
IRHFIAYKNQ DHGAWLRGGD VWLDSCRFAD NGIGLTLASG GTFPYDDGSK QEIKNSLFVG 
ESGNVGTEMM DNRIWGPGGL DHSGRTLPIG QNFPIRGIQL YDGPINIQNC TFRKFVALEG 
RHTSALAFRL NNAWQSCPHN NVTGIAFEDV PITSRVFFGE PGPWFNQLDM DGDKTSVFHD 
VDGSVSEYPG SYLTKNDNWL VRHPDCINVP DWRGAICSGC YAQMYIQAYK TSNLRMKIIK 
NDFPSHPLYL EGALTRSTHY QQYQPVVTLQ KGYTIHWDQT APAELAIWLI NFNKGDWIRV 
GLCYPRGTTF SILSDVHNRL LKQTSKTGVF VRTLQMDKVE QSYPGRSHYY WDEDSGLLFL 
KLKAQNEREK FAFCSMKGCE RIKIKALIPK NAGVSDCTAT AYPKFTERAV VDVPMPKKLF 
GSQLKTKDHF LEVKMESSKQ HFFHLWNDFA YIEVDGKKYP SSEDGIQVVV IDGNQGRVVS 
HTSFRNSILQ GIPWQLFNYV ATIPDNSIVL MASKGRYVSR GPWTRVLEKL GADRGLKLKE 
QMAFVGFKGS FRPIWVTLDT EDHKAKIFQV VPIPVVKKKK L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CEMIP

Associated with

Other Information

Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss. PubMed ID: 14577002

Upregulation of the KIAA1199 gene is associated with cellular mortality. PubMed ID: 16157444

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10574462

Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. PubMed ID: 11247670

Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues. PubMed ID: 12471561

Clinicopathologic significance of KIAA1199 overexpression in human gastric cancer. PubMed ID: 19434458

Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells. PubMed ID: 21772334

Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer. PubMed ID: 22970280

Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration. PubMed ID: 23990668

Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PubMed ID: 23936024

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization. PubMed ID: 23509262

N-Terminal signal sequence is required for cellular trafficking and hyaluronan-depolymerization of KIAA1199. PubMed ID: 24269685