Icmt | ENSMUSG00000039662 | NCBI 57295

Details for: Icmt

Gene ID: 57295

Symbol: Icmt

Ensembl ID: ENSMUSG00000039662

Description: isoprenylcysteine carboxyl methyltransferase

Associated with

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-MMU-163841)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Raf/map kinase cascade
(R-MMU-5673001)
Ras processing
(R-MMU-9648002)
Signal transduction
(R-MMU-162582)
Bone mineralization
(GO:0030282)
C-terminal protein methylation
(GO:0006481)
Camp response element binding protein binding
(GO:0008140)
Determination of adult lifespan
(GO:0008340)
Endoplasmic reticulum
(GO:0005783)
Fibroblast proliferation
(GO:0048144)
In utero embryonic development
(GO:0001701)
Liver development
(GO:0001889)
Membrane
(GO:0016020)
Methylation
(GO:0032259)
Methyltransferase activity
(GO:0008168)
Multicellular organism growth
(GO:0035264)
Neuromuscular process
(GO:0050905)
Positive regulation of fibroblast proliferation
(GO:0048146)
Protein c-terminal s-isoprenylcysteine carboxyl o-methyltransferase activity
(GO:0004671)
Protein localization
(GO:0008104)
Protein methylation
(GO:0006479)
Regulation of cellular senescence
(GO:2000772)
Regulation of protein localization
(GO:0032880)
Regulation of ras protein signal transduction
(GO:0046578)
S-adenosylhomocysteine metabolic process
(GO:0046498)
S-adenosylmethioninamine metabolic process
(GO:0046499)
Tor signaling
(GO:0031929)
Transferase activity
(GO:0016740)

Other Information

Proteins

Protein-S-isoprenylcysteine O-methyltransferase
Q3U4N2_MOUSE

Genular Protein ID: 1016869632

Symbol: ICMT_MOUSE

Name: Protein-S-isoprenylcysteine O-methyltransferase

UniProtKB Accession Codes:

Q9EQK7

Database IDs:

Citations:

PubMed ID: 10649571

Title: Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.

PubMed ID: 10649571

DOI: 10.1038/72101

PubMed ID: 17652517

Title: HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.

PubMed ID: 17652517

DOI: 10.1073/pnas.0704212104

Sequence Information:

Length: 283
Mass: 31790
Checksum: A6C17436EDC27F40
Sequence:

MAAARRGSAG SEARLSLATF LLGASVLALP LLTRAGLQGR TGLALYVAGL NALLLLLYRP 
PRYQIAIRAC FLGFVFGCGV LLSFSQSSWN HFGWYVCSLS LFHYSEYLVT AVNNPKSLSL 
DSFLLNHSLE YTVAALSSWI EFTLENIFWP ELKQITWLSA TGLLMVVFGE CLRKAAMFTA 
GSNFNHVVQS EKSDTHTLVT SGVYAWCRHP SYVGWFYWSI GTQVMLCNPI CGVVYALTVW 
RFFRDRTEEE EISLIHFFGE EYLDYKKRVP TGLPFIKGVK VEL

Genular Protein ID: 3388740351

Symbol: Q3U4N2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U4N2

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 284
Mass: 31872
Checksum: 46036C438843465E
Sequence:

MAGCAARVPP GSEARLSLAT FLLGASVLAL PLLTRAGLQG RTGLALYVAG LNALLLLLYR 
PPRYQIAIRA CFLGFVFGCG VLLSFSQSSW NHFGWYVCSL SLFHYSEYLV TAVNNPKSLS 
LDSFLLNHSL EYTVAALSSW IEFTLENIFW PELKQITWLS ATGLLMVVFG ECLRKAAMFT 
AGSNFNHVVQ SEKSDTHTLV TSGVYAWCRH PSYVGWFYWS IGTQVMLCNP ICGVVYALTV 
WRFFRDRTEE EEISLIHFFG EEYLDYKKRV PTGLPFIKGV KVEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Icmt

Associated with

Other Information

Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. PubMed ID: 10649571

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. PubMed ID: 17652517

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303