Details for: BAG1

Gene ID: 573

Symbol: BAG1

Ensembl ID: ENSG00000107262

Description: BAG cochaperone 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 223.4720
    Cell Significance Index: -34.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 178.0847
    Cell Significance Index: -45.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 110.9888
    Cell Significance Index: -45.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.5311
    Cell Significance Index: -51.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.1925
    Cell Significance Index: -49.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.3313
    Cell Significance Index: -51.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.3531
    Cell Significance Index: -45.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.7157
    Cell Significance Index: -41.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.7866
    Cell Significance Index: -42.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3273
    Cell Significance Index: -52.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9032
    Cell Significance Index: -36.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 6.5226
    Cell Significance Index: 104.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3048
    Cell Significance Index: -11.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.2824
    Cell Significance Index: 615.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.2199
    Cell Significance Index: 25.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.9615
    Cell Significance Index: 205.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.7277
    Cell Significance Index: 101.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.0678
    Cell Significance Index: 228.6400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.9852
    Cell Significance Index: 6.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6783
    Cell Significance Index: 482.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.6081
    Cell Significance Index: 39.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4908
    Cell Significance Index: 306.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4337
    Cell Significance Index: 110.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2829
    Cell Significance Index: 65.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2696
    Cell Significance Index: 20.9000
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.2192
    Cell Significance Index: 6.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0714
    Cell Significance Index: 96.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8304
    Cell Significance Index: 118.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5689
    Cell Significance Index: 73.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5569
    Cell Significance Index: 33.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4627
    Cell Significance Index: 646.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4189
    Cell Significance Index: 40.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.3498
    Cell Significance Index: 16.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3099
    Cell Significance Index: 715.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2225
    Cell Significance Index: 77.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1586
    Cell Significance Index: 1046.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1579
    Cell Significance Index: 81.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.0699
    Cell Significance Index: 15.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0619
    Cell Significance Index: 145.8300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9302
    Cell Significance Index: 7.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8825
    Cell Significance Index: 114.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8735
    Cell Significance Index: 45.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8301
    Cell Significance Index: 9.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6855
    Cell Significance Index: 12.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5650
    Cell Significance Index: 9.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5196
    Cell Significance Index: 13.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4190
    Cell Significance Index: 53.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3630
    Cell Significance Index: 35.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3370
    Cell Significance Index: 64.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3126
    Cell Significance Index: 53.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2857
    Cell Significance Index: 6.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2820
    Cell Significance Index: 7.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1979
    Cell Significance Index: 23.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1555
    Cell Significance Index: 114.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1468
    Cell Significance Index: 29.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1366
    Cell Significance Index: 27.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1186
    Cell Significance Index: 4.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0818
    Cell Significance Index: 13.3100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0800
    Cell Significance Index: 0.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0481
    Cell Significance Index: 1.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0477
    Cell Significance Index: 36.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0031
    Cell Significance Index: 0.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0009
    Cell Significance Index: -0.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0069
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0127
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0153
    Cell Significance Index: -28.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0226
    Cell Significance Index: -2.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0320
    Cell Significance Index: -59.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0386
    Cell Significance Index: -59.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0446
    Cell Significance Index: -60.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0472
    Cell Significance Index: -26.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0519
    Cell Significance Index: -32.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0599
    Cell Significance Index: -1.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0638
    Cell Significance Index: -0.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0879
    Cell Significance Index: -39.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0950
    Cell Significance Index: -1.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1060
    Cell Significance Index: -8.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1064
    Cell Significance Index: -22.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1238
    Cell Significance Index: -35.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1249
    Cell Significance Index: -14.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1855
    Cell Significance Index: -4.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1946
    Cell Significance Index: -22.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2417
    Cell Significance Index: -14.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2795
    Cell Significance Index: -40.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3421
    Cell Significance Index: -7.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4250
    Cell Significance Index: -26.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4849
    Cell Significance Index: -10.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4943
    Cell Significance Index: -37.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4993
    Cell Significance Index: -51.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5303
    Cell Significance Index: -14.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6179
    Cell Significance Index: -41.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6724
    Cell Significance Index: -7.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6824
    Cell Significance Index: -20.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6921
    Cell Significance Index: -17.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7128
    Cell Significance Index: -40.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7147
    Cell Significance Index: -37.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7257
    Cell Significance Index: -44.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8387
    Cell Significance Index: -22.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9629
    Cell Significance Index: -24.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional Chaperone:** BAG1 acts as a molecular chaperone, facilitating protein folding, unfolding, and translocation. Its ability to interact with various client proteins makes it a crucial component of the Hsp90 chaperone complex. 2. **Apoptosis Regulation:** BAG1 modulates the apoptotic process by interacting with pro-apoptotic and anti-apoptotic proteins, thereby influencing cell survival and death. 3. **Stress Response:** BAG1 is involved in regulating cellular responses to various forms of stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. 4. **Cellular Localization:** BAG1 is detected in multiple cellular compartments, including the cytosol, nucleus, and membrane, highlighting its dynamic and versatile nature. **Pathways and Functions:** BAG1 interacts with numerous proteins to regulate various cellular processes, including: 1. **Hsp90 Chaperone Complex:** BAG1 forms a ternary complex with Hsp90 and peptidyl-prolyl cis-trans isomerase (PPIase) to regulate the activity of client proteins. 2. **Apoptosis Signaling:** BAG1 interacts with pro-apoptotic and anti-apoptotic proteins, modulating the apoptotic process. 3. **Heat Shock Response:** BAG1 regulates the heat shock response by interacting with heat shock transcription factor 1 (HSF1) and other heat shock proteins. 4. **Cellular Stress Response:** BAG1 is involved in regulating cellular responses to various forms of stress, including oxidative stress and endoplasmic reticulum stress. **Clinical Significance:** Dysregulation of BAG1 has been implicated in various diseases, including: 1. **Cancer:** BAG1 overexpression has been linked to various types of cancer, including breast, prostate, and lung cancer, where it promotes cell survival and resistance to apoptosis. 2. **Neurodegenerative Diseases:** BAG1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates protein folding and aggregation. 3. **Cardiovascular Diseases:** BAG1 plays a crucial role in maintaining cardiac function, and its dysregulation has been linked to cardiovascular diseases, including heart failure and arrhythmias. In conclusion, BAG1 is a multifaceted molecular chaperone that plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of BAG1 in maintaining tissue integrity and function. Further research is needed to fully elucidate the mechanisms by which BAG1 regulates cellular processes and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 1201954727

Symbol: BAG1_HUMAN

Name: BAG family molecular chaperone regulator 1

UniProtKB Accession Codes:

Q99933 O75315 Q14414 Q53H32 Q5VZE8 Q5VZE9 Q5VZF0 Q96TG2 Q9Y2V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8524784

Title: A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.

PubMed ID: 8524784

DOI: 10.1073/pnas.92.25.11465

PubMed ID: 8812483

Title: Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.

PubMed ID: 8812483

DOI: 10.1006/geno.1996.0389

PubMed ID: 15986447

Title: Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity.

PubMed ID: 15986447

DOI: 10.1002/ijc.21259

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9396724

Title: Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.

PubMed ID: 9396724

DOI: 10.1042/bj3280807

PubMed ID: 9305631

Title: BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

PubMed ID: 9305631

DOI: 10.1093/emboj/16.16.4887

PubMed ID: 9679980

Title: Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

PubMed ID: 9679980

PubMed ID: 9582267

Title: p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

PubMed ID: 9582267

DOI: 10.1093/emboj/17.10.2736

PubMed ID: 9873016

Title: An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.

PubMed ID: 9873016

DOI: 10.1074/jbc.274.2.781

PubMed ID: 10477749

Title: A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.

PubMed ID: 10477749

DOI: 10.1083/jcb.146.5.929

PubMed ID: 12724406

Title: Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions.

PubMed ID: 12724406

DOI: 10.1128/mcb.23.10.3477-3486.2003

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 27474739

Title: Non-canonical interactions between heat shock cognate protein 70 (Hsc70) and Bcl2-associated anthanogene (BAG) co-chaperones are important for client release.

PubMed ID: 27474739

DOI: 10.1074/jbc.m116.742502

PubMed ID: 11222862

Title: Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors.

PubMed ID: 11222862

DOI: 10.1126/science.1057268

Sequence Information:

  • Length: 345
  • Mass: 38779
  • Checksum: 8B40EF078C66335F
  • Sequence:
    • MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR STASGHDRPT 
RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW SEEATQSEEA TQGEEMNRSQ 
EVTRDEESTR SEEVTREEMA AAGLTVTVTH SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV 
IGVPQSFQKL IFKGKSLKEM ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV 
EKIADQLEEL NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN 
FKDSRLKRKG LVKKVQAFLA ECDTVEQNIC QETERLQSTN FALAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.