Details for: BAG1

Gene ID: 573

Symbol: BAG1

Ensembl ID: ENSG00000107262

Description: BAG cochaperone 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.04
    Marker Score: 3200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.77
    Marker Score: 2186
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.65
    Marker Score: 19732
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.59
    Marker Score: 6334
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.58
    Marker Score: 9961
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.48
    Marker Score: 4531
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.46
    Marker Score: 83636
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.37
    Marker Score: 3485
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.35
    Marker Score: 5914
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.3
    Marker Score: 779
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.16
    Marker Score: 2782
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.14
    Marker Score: 1460
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.13
    Marker Score: 1426
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.1
    Marker Score: 13404
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.07
    Marker Score: 599
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.02
    Marker Score: 4609.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.97
    Marker Score: 3273
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.97
    Marker Score: 3482
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.96
    Marker Score: 6142
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.96
    Marker Score: 1874
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.95
    Marker Score: 2079.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.94
    Marker Score: 691
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9
    Marker Score: 19225
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.89
    Marker Score: 5394
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.88
    Marker Score: 596
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.88
    Marker Score: 16196.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7331
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.86
    Marker Score: 4993
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.86
    Marker Score: 64484
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.86
    Marker Score: 869
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.86
    Marker Score: 2959
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.85
    Marker Score: 912
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.84
    Marker Score: 7540
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.84
    Marker Score: 1070
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.83
    Marker Score: 14323.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.79
    Marker Score: 3364
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.78
    Marker Score: 8557
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.78
    Marker Score: 430
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.78
    Marker Score: 917
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.77
    Marker Score: 1988
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.77
    Marker Score: 2502
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.74
    Marker Score: 518
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.72
    Marker Score: 14966.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.72
    Marker Score: 1531.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.71
    Marker Score: 3871
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.7
    Marker Score: 1803
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.7
    Marker Score: 559
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.63
    Marker Score: 563
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.63
    Marker Score: 1627
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.63
    Marker Score: 2338.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.61
    Marker Score: 3835
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.61
    Marker Score: 1883
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6
    Marker Score: 396
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.59
    Marker Score: 8366
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.59
    Marker Score: 1610
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.58
    Marker Score: 40361
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.57
    Marker Score: 653
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.57
    Marker Score: 590
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.57
    Marker Score: 450
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.56
    Marker Score: 5545
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.56
    Marker Score: 807
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.55
    Marker Score: 10108
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.55
    Marker Score: 385
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.55
    Marker Score: 1606
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.54
    Marker Score: 519
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.54
    Marker Score: 5709
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.54
    Marker Score: 3074
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.53
    Marker Score: 2363
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.53
    Marker Score: 385
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.53
    Marker Score: 389
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.52
    Marker Score: 526
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.52
    Marker Score: 84898
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.51
    Marker Score: 859
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.51
    Marker Score: 16956
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.5
    Marker Score: 2418
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.49
    Marker Score: 1647
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.49
    Marker Score: 1792
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.48
    Marker Score: 354.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.48
    Marker Score: 2887
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.48
    Marker Score: 3009
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.47
    Marker Score: 1567
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.46
    Marker Score: 439
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.45
    Marker Score: 1055
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.44
    Marker Score: 6194
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.43
    Marker Score: 533
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.43
    Marker Score: 968
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.43
    Marker Score: 318.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.42
    Marker Score: 320
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.42
    Marker Score: 896
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.41
    Marker Score: 669
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.4
    Marker Score: 1014.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.4
    Marker Score: 859
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.39
    Marker Score: 639
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.39
    Marker Score: 2282
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.37
    Marker Score: 575
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.37
    Marker Score: 440
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.37
    Marker Score: 3780.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.36
    Marker Score: 913
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.36
    Marker Score: 751
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.36
    Marker Score: 359

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Other Information

**Key characteristics:** - BAG1 is a chaperone protein that is highly expressed in epithelial cells, including conjunctival epithelial cell, epithelial cell of urethra, and basal cell of epithelium of trachea, prostate epithelium, mammary luminal epithelium, secretory cell, fibroblast of mammary gland, bladder urothelial cell, kidney collecting duct principal cell, and stem cell of epidermis. - It is a key regulator of the heat stress response, acting as a chaperone for heat shock proteins and facilitating their refolding and folding. - BAG1 also plays a role in the apoptotic process, where it helps to regulate the ubiquitination and degradation of damaged or misfolded proteins. **Pathways and functions:** - BAG1 is involved in the adenyl-nucleotide exchange factor activity pathway, where it participates in the regulation of cell cycle progression and apoptosis. - It also plays a critical role in the cell surface receptor signaling pathway, where it interacts with various signaling molecules and regulates their activity. - BAG1 is involved in cellular responses to stimuli, cellular responses to stress, and cellular response to heat stress. - It is also involved in the chaperone-dependent protein refolding pathway, where it facilitates the folding and refolding of various cellular proteins. - BAG1 also plays a role in the regulation of the hsf1-mediated heat shock response, where it helps to protect proteins from degradation. **Clinical significance:** - Mutations in the BAG1 gene have been linked to various human diseases, including breast cancer, lung cancer, and liver cancer. - BAG1 inhibitors are being investigated as potential therapeutic agents for these diseases, as they could provide a way to selectively target cancer cells and prevent their growth.

Genular Protein ID: 1201954727

Symbol: BAG1_HUMAN

Name: BAG family molecular chaperone regulator 1

UniProtKB Accession Codes:

Q99933 O75315 Q14414 Q53H32 Q5VZE8 Q5VZE9 Q5VZF0 Q96TG2 Q9Y2V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 26 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8524784

Title: A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.

PubMed ID: 8524784

DOI: 10.1073/pnas.92.25.11465

PubMed ID: 8812483

Title: Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.

PubMed ID: 8812483

DOI: 10.1006/geno.1996.0389

PubMed ID: 15986447

Title: Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity.

PubMed ID: 15986447

DOI: 10.1002/ijc.21259

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9396724

Title: Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.

PubMed ID: 9396724

DOI: 10.1042/bj3280807

PubMed ID: 9305631

Title: BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

PubMed ID: 9305631

DOI: 10.1093/emboj/16.16.4887

PubMed ID: 9679980

Title: Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

PubMed ID: 9679980

PubMed ID: 9582267

Title: p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

PubMed ID: 9582267

DOI: 10.1093/emboj/17.10.2736

PubMed ID: 9873016

Title: An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.

PubMed ID: 9873016

DOI: 10.1074/jbc.274.2.781

PubMed ID: 10477749

Title: A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.

PubMed ID: 10477749

DOI: 10.1083/jcb.146.5.929

PubMed ID: 12724406

Title: Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions.

PubMed ID: 12724406

DOI: 10.1128/mcb.23.10.3477-3486.2003

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 27474739

Title: Non-canonical interactions between heat shock cognate protein 70 (Hsc70) and Bcl2-associated anthanogene (BAG) co-chaperones are important for client release.

PubMed ID: 27474739

DOI: 10.1074/jbc.m116.742502

PubMed ID: 11222862

Title: Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors.

PubMed ID: 11222862

DOI: 10.1126/science.291.5508.1553

Sequence Information:

  • Length: 345
  • Mass: 38779
  • Checksum: 8B40EF078C66335F
  • Sequence:
    • MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR STASGHDRPT 
RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW SEEATQSEEA TQGEEMNRSQ 
EVTRDEESTR SEEVTREEMA AAGLTVTVTH SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV 
IGVPQSFQKL IFKGKSLKEM ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV 
EKIADQLEEL NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN 
FKDSRLKRKG LVKKVQAFLA ECDTVEQNIC QETERLQSTN FALAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.