Details for: Smpdl3a

Gene ID: 57319

Symbol: Smpdl3a

Ensembl ID: ENSMUSG00000019872

Description: sphingomyelin phosphodiesterase, acid-like 3A

Associated with

Other Information

Genular Protein ID: 3316489466

Symbol: ASM3A_MOUSE

Name: Acid sphingomyelinase-like phosphodiesterase 3a

UniProtKB Accession Codes:

P70158 Q3U8C2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 6 PIRSF 1 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 25288789

Title: Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages.

PubMed ID: 25288789

DOI: 10.1074/jbc.m114.612341

PubMed ID: 26095358

Title: The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity.

PubMed ID: 26095358

DOI: 10.1016/j.celrep.2015.05.006

PubMed ID: 26792860

Title: Structural basis for nucleotide hydrolysis by the acid sphingomyelinase-like phosphodiesterase SMPDL3A.

PubMed ID: 26792860

DOI: 10.1074/jbc.m115.711085

Sequence Information:

  • Length: 445
  • Mass: 49858
  • Checksum: 20D986E3463CB720
  • Sequence:
    • MALLGNFLCC LLVAWLCGPG LGVPLAPADR APAVGQFWHV TDLHLDPTYH ITDDRTKVCA 
SSKGANASNP GPFGDVLCDS PYQLILSAFD FIKNSGQEAS FMIWTGDSPP HVPVPELSTG 
TVIKVITNMT MTVQNLFPNL QVFPALGNHD YWPQDQLPIV TSKVYSAVAD LWKPWLGEEA 
ISTLKKGGFY SQKVASNPGL RIISLNTNLY YGPNIMTLNK TDPANQFEWL ENTLNSSLWN 
KEKVYIIAHV PVGYLPYATD TPAIRQYYNE KLLDIFRRYS SVIAGQFYGH THRDSLMVLS 
DKNGNPLNSV FVAPAVTPVK GVLQKETNNP GVRLFQYKPG DYTLLDMVQY YLNLTEANLK 
GESNWTLEYV LTQAYSVADL QPKSLYALVQ QFATKDSKQF LKYYHYYFVS YDSSATCDQH 
CKTLQVCAIM NLDSMSYDDC LKQHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.