Park7 | ENSMUSG00000028964 | NCBI 57320

Details for: Park7

Gene ID: 57320

Symbol: Park7

Ensembl ID: ENSMUSG00000028964

Description: Parkinson disease (autosomal recessive, early onset) 7

Associated with

Aggrephagy
(R-MMU-9646399)
Macroautophagy
(R-MMU-1632852)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Selective autophagy
(R-MMU-9663891)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Adult locomotory behavior
(GO:0008344)
Autophagy
(GO:0006914)
Cellular response to glyoxal
(GO:0036471)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to reactive oxygen species
(GO:0034614)
Copper ion binding
(GO:0005507)
Cupric ion binding
(GO:1903135)
Cuprous ion binding
(GO:1903136)
Cytokine binding
(GO:0019955)
Detoxification of copper ion
(GO:0010273)
Detoxification of mercury ion
(GO:0050787)
Dna-binding transcription factor binding
(GO:0140297)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Enzyme binding
(GO:0019899)
Glucose homeostasis
(GO:0042593)
Glutathione deglycation
(GO:0036531)
Glycolate biosynthetic process
(GO:0046295)
Glyoxalase (glycolic acid-forming) activity
(GO:1990422)
Hydrogen peroxide metabolic process
(GO:0042743)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Insulin secretion
(GO:0030073)
Kinase binding
(GO:0019900)
L-dopa decarboxylase activator activity
(GO:0036478)
Lactate biosynthetic process
(GO:0019249)
Mercury ion binding
(GO:0045340)
Mitochondrion organization
(GO:0007005)
Mrna binding
(GO:0003729)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032435)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of protein export from nucleus
(GO:0046826)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of protein sumoylation
(GO:0033234)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of ubiquitin-protein transferase activity
(GO:0051444)
Nuclear androgen receptor binding
(GO:0050681)
Oxidoreductase activity, acting on peroxide as acceptor
(GO:0016684)
Oxygen sensor activity
(GO:0019826)
Peptidase activity
(GO:0008233)
Peptidyl-arginine deglycation
(GO:0036527)
Peptidyl-cysteine deglycation
(GO:0036526)
Peptidyl-lysine deglycation
(GO:0036528)
Peroxiredoxin activity
(GO:0051920)
Positive regulation of acute inflammatory response to antigenic stimulus
(GO:0002866)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of nad(p)h oxidase activity
(GO:0033864)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein deglycase activity
(GO:0036524)
Protein deglycation, glyoxal removal
(GO:0036529)
Protein homodimerization activity
(GO:0042803)
Protein stabilization
(GO:0050821)
Proteolysis
(GO:0006508)
Regulation of inflammatory response
(GO:0050727)
Regulation of neuron apoptotic process
(GO:0043523)
Response to hydrogen peroxide
(GO:0042542)
Response to oxidative stress
(GO:0006979)
Rna binding
(GO:0003723)
Scaffold protein binding
(GO:0097110)
Signaling receptor binding
(GO:0005102)
Single fertilization
(GO:0007338)
Small protein activating enzyme binding
(GO:0044388)
Superoxide dismutase copper chaperone activity
(GO:0016532)
Synaptic transmission, dopaminergic
(GO:0001963)
Transcription coactivator activity
(GO:0003713)
Tyrosine 3-monooxygenase activator activity
(GO:0036470)
Ubiquitin-like protein conjugating enzyme binding
(GO:0044390)
Ubiquitin-specific protease binding
(GO:1990381)

Other Information

Proteins

PARK7_MOUSE

Genular Protein ID: 2633758718

Symbol: PARK7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q99LX0 O88306 Q3THB9 Q3U509

Database IDs:

Citations:

PubMed ID: 11223268

Title: Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.

PubMed ID: 11223268

DOI: 10.1016/s0378-1119(00)00590-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14749723

Title: DJ-1 has a role in antioxidative stress to prevent cell death.

PubMed ID: 14749723

DOI: 10.1038/sj.embor.7400074

PubMed ID: 15784737

Title: Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

PubMed ID: 15784737

DOI: 10.1073/pnas.0501282102

PubMed ID: 17015834

Title: DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.

PubMed ID: 17015834

DOI: 10.1073/pnas.0607260103

PubMed ID: 17766438

Title: DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.

PubMed ID: 17766438

DOI: 10.1073/pnas.0703219104

PubMed ID: 19276172

Title: Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1.

PubMed ID: 19276172

DOI: 10.1096/fj.08-125153

PubMed ID: 20800516

Title: The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage.

PubMed ID: 20800516

DOI: 10.1016/j.bcmd.2010.07.014

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21097510

Title: DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B.

PubMed ID: 21097510

DOI: 10.1074/jbc.m110.147371

PubMed ID: 21068725

Title: Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

PubMed ID: 21068725

DOI: 10.1038/nature09536

PubMed ID: 20186336

Title: Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.

PubMed ID: 20186336

DOI: 10.1371/journal.pone.0009367

PubMed ID: 22555455

Title: The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production.

PubMed ID: 22555455

DOI: 10.1038/cdd.2012.55

PubMed ID: 22523093

Title: Human DJ-1 and its homologs are novel glyoxalases.

PubMed ID: 22523093

DOI: 10.1093/hmg/dds155

PubMed ID: 22611253

Title: Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.

PubMed ID: 22611253

DOI: 10.1093/jmcb/mjs025

PubMed ID: 23847046

Title: DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes.

PubMed ID: 23847046

DOI: 10.1093/hmg/ddt332

PubMed ID: 23792957

Title: Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.

PubMed ID: 23792957

DOI: 10.1074/jbc.m113.482091

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 26021615

Title: Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis.

PubMed ID: 26021615

DOI: 10.1038/cr.2015.63

PubMed ID: 26422139

Title: DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death.

PubMed ID: 26422139

DOI: 10.1371/journal.pone.0138535

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

Sequence Information:

Length: 189
Mass: 20021
Checksum: 877C825CCA07468F
Sequence:

MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV MICPDTSLED 
AKTQGPYDVV VLPGGNLGAQ NLSESPMVKE ILKEQESRKG LIAAICAGPT ALLAHEVGFG 
CKVTTHPLAK DKMMNGSHYS YSESRVEKDG LILTSRGPGT SFEFALAIVE ALVGKDMANQ 
VKAPLVLKD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Park7

Associated with

Other Information

Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. PubMed ID: 11223268

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DJ-1 has a role in antioxidative stress to prevent cell death. PubMed ID: 14749723

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. PubMed ID: 15784737

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. PubMed ID: 17015834

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. PubMed ID: 17766438

Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. PubMed ID: 19276172

The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage. PubMed ID: 20800516

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B. PubMed ID: 21097510

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. PubMed ID: 21068725

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PubMed ID: 20186336

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. PubMed ID: 22555455

Human DJ-1 and its homologs are novel glyoxalases. PubMed ID: 22523093

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. PubMed ID: 22611253

DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. PubMed ID: 23847046

Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. PubMed ID: 23792957

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. PubMed ID: 26021615

DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death. PubMed ID: 26422139

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. PubMed ID: 31536960