CBX8 | ENSG00000141570 | NCBI 57332

Details for: CBX8

Gene ID: 57332

Symbol: CBX8

Ensembl ID: ENSG00000141570

Description: chromobox 8

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Metabolism of proteins
(R-HSA-392499)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna methylation proteins
(R-HSA-4655427)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Transcriptional regulation by runx1
(R-HSA-8878171)
Cellular response to hydrogen peroxide
(GO:0070301)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Heterochromatin
(GO:0000792)
Methylated histone binding
(GO:0035064)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of dna repair
(GO:0045739)
Prc1 complex
(GO:0035102)
Protein binding
(GO:0005515)
Single-stranded rna binding
(GO:0003727)
Ubiquitin-protein transferase activator activity
(GO:0097027)

Other Information

Proteins

Chromobox protein homolog 8

Genular Protein ID: 2588805490

Symbol: CBX8_HUMAN

Name: Chromobox protein homolog 8

UniProtKB Accession Codes:

Q9HC52 Q96H39 Q9NR07

Database IDs:

Citations:

PubMed ID: 10825164

Title: HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.

PubMed ID: 10825164

DOI: 10.1074/jbc.m001835200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11313972

Title: The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.

PubMed ID: 11313972

DOI: 10.1038/sj.onc.1204108

PubMed ID: 12167701

Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

PubMed ID: 12167701

DOI: 10.1128/mcb.22.17.6070-6078.2002

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19636380

Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

PubMed ID: 19636380

DOI: 10.1371/journal.pone.0006380

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21282530

Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PubMed ID: 21282530

DOI: 10.1074/mcp.m110.002642

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21047797

Title: Recognition and specificity determinants of the human cbx chromodomains.

PubMed ID: 21047797

DOI: 10.1074/jbc.m110.191411

Sequence Information:

Length: 389
Mass: 43396
Checksum: 651263C85B0ECD93
Sequence:

MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER 
EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSAR GIRIPYPGRS PQDLASTSRA 
REGLRNMGLS PPASSTSTSS TCRAEAPRDR DRDRDRDRER DRERERERER ERERERERER 
GTSRVDDKPS SPGDSSKKRG PKPRKELPDP SQRPLGEPSA GLGEYLKGRK LDDTPSGAGK 
FPAGHSVIQL ARRQDSDLVQ CGVTSPSSAE ATGKLAVDTF PARVIKHRAA FLEAKGQGAL 
DPNGTRVRHG SGPPSSGGGL YRDMGAQGGR PSLIARIPVA RILGDPEEES WSPSLTNLEK 
VVVTDVTSNF LTVTIKESNT DQGFFKEKR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CBX8

Associated with

Other Information

HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. PubMed ID: 10825164

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. PubMed ID: 11313972

The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. PubMed ID: 12167701

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PubMed ID: 19636380

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. PubMed ID: 21282530

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Recognition and specificity determinants of the human cbx chromodomains. PubMed ID: 21047797