AICDA | ENSG00000111732 | NCBI 57379

Details for: AICDA

Gene ID: 57379

Symbol: AICDA

Ensembl ID: ENSG00000111732

Description: activation induced cytidine deaminase

Associated with

Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Developmental biology
(R-HSA-1266738)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
B cell differentiation
(GO:0030183)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytidine deaminase activity
(GO:0004126)
Cytidine deamination
(GO:0009972)
Cytidine to uridine editing
(GO:0016554)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to virus
(GO:0051607)
Deoxycytidine deaminase activity
(GO:0047844)
Dna cytosine deamination
(GO:0070383)
Dna demethylation
(GO:0080111)
Identical protein binding
(GO:0042802)
Isotype switching
(GO:0045190)
Mrna processing
(GO:0006397)
Negative regulation of dna methylation-dependent heterochromatin formation
(GO:0090310)
Negative regulation of single stranded viral rna replication via double stranded dna intermediate
(GO:0045869)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of nuclear cell cycle dna replication
(GO:0033262)
Rna binding
(GO:0003723)
Somatic diversification of immunoglobulins
(GO:0016445)
Somatic hypermutation of immunoglobulin genes
(GO:0016446)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Single-stranded DNA cytosine deaminase
Q7Z599_HUMAN

Genular Protein ID: 179899687

Symbol: AICDA_HUMAN

Name: Single-stranded DNA cytosine deaminase

UniProtKB Accession Codes:

Q9GZX7 Q6QJ81 Q8NFC1

Database IDs:

Citations:

PubMed ID: 10950930

Title: Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene.

PubMed ID: 10950930

DOI: 10.1006/geno.2000.6268

PubMed ID: 11007475

Title: Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

PubMed ID: 11007475

DOI: 10.1016/s0092-8674(00)00079-9

PubMed ID: 12202747

Title: Somatic hypermutation of the AID transgene in B and non-B cells.

PubMed ID: 12202747

DOI: 10.1073/pnas.192442899

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14769937

Title: Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.

PubMed ID: 14769937

DOI: 10.1073/pnas.0307335101

PubMed ID: 16387847

Title: PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

PubMed ID: 16387847

DOI: 10.1073/pnas.0509969103

PubMed ID: 18722174

Title: Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

PubMed ID: 18722174

DOI: 10.1016/j.molcel.2008.07.009

PubMed ID: 20507984

Title: GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.

PubMed ID: 20507984

DOI: 10.1074/jbc.m110.131441

PubMed ID: 21496894

Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

PubMed ID: 21496894

DOI: 10.1016/j.cell.2011.03.022

PubMed ID: 21385873

Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.

PubMed ID: 21385873

DOI: 10.1074/jbc.m110.208769

PubMed ID: 21659520

Title: Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.

PubMed ID: 21659520

DOI: 10.1074/jbc.m111.235721

PubMed ID: 21518874

Title: Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

PubMed ID: 21518874

DOI: 10.1073/pnas.1104423108

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 23277564

Title: Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.

PubMed ID: 23277564

DOI: 10.1073/pnas.1214538110

PubMed ID: 32484799

Title: Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID.

PubMed ID: 32484799

DOI: 10.1172/jci131297

PubMed ID: 27258794

Title: Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.

PubMed ID: 27258794

DOI: 10.1016/j.dnarep.2016.05.029

PubMed ID: 11544457

Title: Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels.

PubMed ID: 11544457

DOI: 10.1067/mai.2001.117456

PubMed ID: 14962793

Title: Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to activation-induced cytidine deaminase deficiency.

PubMed ID: 14962793

DOI: 10.1016/j.clim.2003.10.007

PubMed ID: 23803409

Title: A novel activation-induced cytidine deaminase (AID) mutation in Brazilian patients with hyper-IgM type 2 syndrome.

PubMed ID: 23803409

DOI: 10.1016/j.clim.2013.05.017

PubMed ID: 26545377

Title: Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients.

PubMed ID: 26545377

DOI: 10.1007/s00251-015-0878-6

PubMed ID: 27716525

Title: Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate.

PubMed ID: 27716525

DOI: 10.1016/j.molimm.2016.09.025

Sequence Information:

Length: 198
Mass: 23954
Checksum: 3C27BB143DB184A9
Sequence:

MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL 
FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK 
AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL 
LPLYEVDDLR DAFRTLGL

Genular Protein ID: 1139777852

Symbol: Q7Z599_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z599

Database IDs:

Citations:

PubMed ID: 15814733

Title: Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis.

PubMed ID: 15814733

Sequence Information:

Length: 111
Mass: 13391
Checksum: D351FC6D79366B62
Sequence:

DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH 
RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AICDA

Associated with

Other Information

Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene. PubMed ID: 10950930

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). PubMed ID: 11007475

Somatic hypermutation of the AID transgene in B and non-B cells. PubMed ID: 12202747

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. PubMed ID: 14769937

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. PubMed ID: 16387847

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. PubMed ID: 18722174

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA. PubMed ID: 20507984

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. PubMed ID: 21496894

CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. PubMed ID: 21385873

Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein. PubMed ID: 21659520

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. PubMed ID: 21518874

BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. PubMed ID: 23166356

Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. PubMed ID: 23277564

Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID. PubMed ID: 32484799

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification. PubMed ID: 27258794

Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels. PubMed ID: 11544457

Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to activation-induced cytidine deaminase deficiency. PubMed ID: 14962793

A novel activation-induced cytidine deaminase (AID) mutation in Brazilian patients with hyper-IgM type 2 syndrome. PubMed ID: 23803409

Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients. PubMed ID: 26545377

Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate. PubMed ID: 27716525

Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. PubMed ID: 15814733