SPC25 | ENSG00000152253 | NCBI 57405

Details for: SPC25

Gene ID: 57405

Symbol: SPC25

Ensembl ID: ENSG00000152253

Description: SPC25 component of NDC80 kinetochore complex

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Attachment of spindle microtubules to kinetochore
(GO:0008608)
Cell division
(GO:0051301)
Chromosome segregation
(GO:0007059)
Cytosol
(GO:0005829)
Kinetochore
(GO:0000776)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Mitotic spindle organization
(GO:0007052)
Ndc80 complex
(GO:0031262)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)

Other Information

Proteins

Kinetochore protein Spc25

Genular Protein ID: 1205412884

Symbol: SPC25_HUMAN

Name: Kinetochore protein Spc25

UniProtKB Accession Codes:

Q9HBM1 A8K4X8 D3DPC0

Database IDs:

Citations:

PubMed ID: 14738735

Title: The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment.

PubMed ID: 14738735

DOI: 10.1016/j.cub.2003.12.058

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14699129

Title: Identification of two novel components of the human NDC80 kinetochore complex.

PubMed ID: 14699129

DOI: 10.1074/jbc.m310224200

PubMed ID: 15961401

Title: Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore.

PubMed ID: 15961401

DOI: 10.1074/jbc.m504070200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23085020

Title: The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.

PubMed ID: 23085020

DOI: 10.1016/j.devcel.2012.09.012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 224
Mass: 26153
Checksum: 6DED3216794F4512
Sequence:

MVEDELALFD KSINEFWNKF KSTDTSCQMA GLRDTYKDSI KAFAEKLSVK LKEEERMVEM 
FLEYQNQISR QNKLIQEKKD NLLKLIAEVK GKKQELEVLT ANIQDLKEEY SRKKETISTA 
NKANAERLKR LQKSADLYKD RLGLEIRKIY GEKLQFIFTN IDPKNPESPF MFSLHLNEAR 
DYEVSDSAPH LEGLAEFQEN VRKTNNFSAF LANVRKAFTA TVYN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPC25

Associated with

Other Information

The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. PubMed ID: 14738735

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of two novel components of the human NDC80 kinetochore complex. PubMed ID: 14699129

Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. PubMed ID: 15961401

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. PubMed ID: 23085020

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163