Details for: ADGRB1

Gene ID: 575

Symbol: ADGRB1

Ensembl ID: ENSG00000181790

Description: adhesion G protein-coupled receptor B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.79
    Marker Score: 3391
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.68
    Marker Score: 6860
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.67
    Marker Score: 3464.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56308
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.51
    Marker Score: 11549
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.51
    Marker Score: 6241
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.47
    Marker Score: 90672
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.47
    Marker Score: 2268
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13380
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.38
    Marker Score: 27385
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.35
    Marker Score: 11561
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.28
    Marker Score: 2597
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.24
    Marker Score: 5759
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.19
    Marker Score: 785
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.18
    Marker Score: 17668
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7668
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.14
    Marker Score: 10720
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 705
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1
    Marker Score: 4256
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.09
    Marker Score: 1837
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.05
    Marker Score: 10855
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16398
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 701.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 599
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.97
    Marker Score: 36838
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.97
    Marker Score: 1195
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.95
    Marker Score: 20182
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 424
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.89
    Marker Score: 282
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.75
    Marker Score: 2153
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 343
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.65
    Marker Score: 287
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.65
    Marker Score: 1524
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 477
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 172
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.52
    Marker Score: 1474
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.46
    Marker Score: 513
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.41
    Marker Score: 173
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.41
    Marker Score: 355
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.36
    Marker Score: 99
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.36
    Marker Score: 381
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.34
    Marker Score: 327
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.32
    Marker Score: 651
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.32
    Marker Score: 580
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.28
    Marker Score: 350
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.27
    Marker Score: 747
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.25
    Marker Score: 85
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.25
    Marker Score: 98
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.23
    Marker Score: 125
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.23
    Marker Score: 136
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.23
    Marker Score: 939
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.2
    Marker Score: 163
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.18
    Marker Score: 193
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.17
    Marker Score: 56
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.16
    Marker Score: 236
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.16
    Marker Score: 188
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.15
    Marker Score: 573
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.15
    Marker Score: 96
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.14
    Marker Score: 252
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.13
    Marker Score: 80
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.13
    Marker Score: 314
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.13
    Marker Score: 81
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.13
    Marker Score: 118
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.12
    Marker Score: 114
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.12
    Marker Score: 1232
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 118
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.11
    Marker Score: 116

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Other Information

**Key characteristics:** * ADGRB1 is a transmembrane protein that is expressed in the plasma membrane of endothelial cells. * It is a member of the immunoglobulin superfamily of cell adhesion molecules. * It is a G protein-coupled receptor, meaning that it is activated by the binding of a G protein. * It is expressed in high levels in cardiac endothelial cells, neurons, and kidney cells. **Pathways and functions:** * ADGRB1 is involved in the regulation of angiogenesis by binding to lipopolysaccharide and promoting cell migration into the tissue. * It is also involved in cell adhesion by binding to extracellular matrix proteins and facilitating cell-cell adhesion. * It is involved in axonogenesis by promoting the migration of neurons along the developing neural tube. * It is involved in cell migration by binding to extracellular matrix proteins and facilitating cell migration. * It is involved in signal transduction by binding to G proteins and activating downstream signaling pathways. **Clinical significance:** * Mutations in ADGRB1 have been linked to a number of human diseases, including cardiovascular disease, stroke, and cancer. * Targeting ADGRB1 has been shown to be a potential therapeutic strategy for these diseases. **Additional information:** * The ADGRB1 gene is located on chromosome 15q21.1. * It is a single-exon gene that encodes a protein of 134 amino acids. * It is expressed in high levels in the brain, heart, and kidney. * It is a well-characterized protein that has been extensively studied.

Genular Protein ID: 3183555813

Symbol: AGRB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14514

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 36 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9393972

Title: A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis.

PubMed ID: 9393972

DOI: 10.1038/sj.onc.1201542

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 9647739

Title: Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1.

PubMed ID: 9647739

DOI: 10.1006/bbrc.1998.8603

PubMed ID: 9790924

Title: Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1.

PubMed ID: 9790924

DOI: 10.1006/bbrc.1998.9408

PubMed ID: 10343108

Title: Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1.

PubMed ID: 10343108

DOI: 10.1159/000015219

PubMed ID: 10748157

Title: Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.

PubMed ID: 10748157

DOI: 10.1074/jbc.m909741199

PubMed ID: 11875720

Title: Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis.

PubMed ID: 11875720

DOI: 10.1038/sj.bjc.6600067

PubMed ID: 12074842

Title: Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells.

PubMed ID: 12074842

DOI: 10.1016/s0168-0102(02)00018-4

PubMed ID: 12507886

Title: Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.

PubMed ID: 12507886

DOI: 10.1016/s0002-9440(10)63794-7

PubMed ID: 15782143

Title: Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor.

PubMed ID: 15782143

DOI: 10.1038/sj.onc.1208317

PubMed ID: 19176395

Title: Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.

PubMed ID: 19176395

DOI: 10.1158/0008-5472.can-08-1166

PubMed ID: 22333914

Title: A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.

PubMed ID: 22333914

DOI: 10.1038/emboj.2012.26

PubMed ID: 22330140

Title: A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.

PubMed ID: 22330140

DOI: 10.1038/onc.2012.1

PubMed ID: 23782696

Title: Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.

PubMed ID: 23782696

DOI: 10.1074/jbc.m113.489757

PubMed ID: 23595754

Title: The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.

PubMed ID: 23595754

DOI: 10.1523/jneurosci.3978-12.2013

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24509909

Title: Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells.

PubMed ID: 24509909

DOI: 10.1096/fj.13-243238

PubMed ID: 26710850

Title: Stalk-dependent and stalk-independent signaling by the adhesion G protein-coupled receptors GPR56 (ADGRG1) and BAI1 (ADGRB1).

PubMed ID: 26710850

DOI: 10.1074/jbc.m115.689349

PubMed ID: 26838550

Title: The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria.

PubMed ID: 26838550

DOI: 10.1126/scisignal.aac6250

Sequence Information:

  • Length: 1584
  • Mass: 173501
  • Checksum: A604E634DDD741F7
  • Sequence:
    • MRGQAAAPGP VWILAPLLLL LLLLGRRARA AAGADAGPGP EPCATLVQGK FFGYFSAAAV 
FPANASRCSW TLRNPDPRRY TLYMKVAKAP VPCSGPGRVR TYQFDSFLES TRTYLGVESF 
DEVLRLCDPS APLAFLQASK QFLQMRRQQP PQHDGLRPRA GPPGPTDDFS VEYLVVGNRN 
PSRAACQMLC RWLDACLAGS RSSHPCGIMQ TPCACLGGEA GGPAAGPLAP RGDVCLRDAV 
AGGPENCLTS LTQDRGGHGA TGGWKLWSLW GECTRDCGGG LQTRTRTCLP APGVEGGGCE 
GVLEEGRQCN REACGPAGRT SSRSQSLRST DARRREELGD ELQQFGFPAP QTGDPAAEEW 
SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC NNSAVCPVHG AWDEWSPWSL 
CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE KQTKFCNIAL CPGRAVDGNW NEWSSWSACS 
ASCSQGRQQR TRECNGPSYG GAECQGHWVE TRDCFLQQCP VDGKWQAWAS WGSCSVTCGA 
GSQRRERVCS GPFFGGAACQ GPQDEYRQCG TQRCPEPHEI CDEDNFGAVI WKETPAGEVA 
AVRCPRNATG LILRRCELDE EGIAYWEPPT YIRCVSIDYR NIQMMTREHL AKAQRGLPGE 
GVSEVIQTLV EISQDGTSYS GDLLSTIDVL RNMTEIFRRA YYSPTPGDVQ NFVQILSNLL 
AEENRDKWEE AQLAGPNAKE LFRLVEDFVD VIGFRMKDLR DAYQVTDNLV LSIHKLPASG 
ATDISFPMKG WRATGDWAKV PEDRVTVSKS VFSTGLTEAD EASVFVVGTV LYRNLGSFLA 
LQRNTTVLNS KVISVTVKPP PRSLRTPLEI EFAHMYNGTT NQTCILWDET DVPSSSAPPQ 
LGPWSWRGCR TVPLDALRTR CLCDRLSTFA ILAQLSADAN MEKATLPSVT LIVGCGVSSL 
TLLMLVIIYV SVWRYIRSER SVILINFCLS IISSNALILI GQTQTRNKVV CTLVAAFLHF 
FFLSSFCWVL TEAWQSYMAV TGHLRNRLIR KRFLCLGWGL PALVVAISVG FTKAKGYSTM 
NYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSK DGITDKKLKE RAGASLWSSC 
VVLPLLALTW MSAVLAVTDR RSALFQILFA VFDSLEGFVI VMVHCILRRE VQDAVKCRVV 
DRQEEGNGDS GGSFQNGHAQ LMTDFEKDVD LACRSVLNKD IAACRTATIT GTLKRPSLPE 
EEKLKLAHAK GPPTNFNSLP ANVSKLHLHG SPRYPGGPLP DFPNHSLTLK RDKAPKSSFV 
GDGDIFKKLD SELSRAQEKA LDTSYVILPT ATATLRPKPK EEPKYSIHID QMPQTRLIHL 
STAPEASLPA RSPPSRQPPS GGPPEAPPAQ PPPPPPPPPP PPQQPLPPPP NLEPAPPSLG 
DPGEPAAHPG PSTGPSTKNE NVATLSVSSL ERRKSRYAEL DFEKIMHTRK RHQDMFQDLN 
RKLQHAAEKD KEVLGPDSKP EKQQTPNKRP WESLRKAHGT PTWVKKELEP LQPSPLELRS 
VEWERSGATI PLVGQDIIDL QTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.