Details for: MAVS
Associated with
Other Information
Genular Protein ID: 1259323517
Symbol: MAVS_HUMAN
Name: Interferon beta promoter stimulator protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16125763
Title: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
PubMed ID: 16125763
PubMed ID: 16153868
Title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.
PubMed ID: 16153868
PubMed ID: 16177806
Title: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
PubMed ID: 16177806
DOI: 10.1038/nature04193
PubMed ID: 16127453
Title: IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
PubMed ID: 16127453
DOI: 10.1038/ni1243
PubMed ID: 18207245
Title: Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling.
PubMed ID: 18207245
PubMed ID: 22427742
Title: Convergent evolution of escape from hepaciviral antagonism in primates.
PubMed ID: 22427742
PubMed ID: 10574462
Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10574462
PubMed ID: 12761501
Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
PubMed ID: 12761501
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16301520
Title: Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.
PubMed ID: 16301520
PubMed ID: 17020950
Title: RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2.
PubMed ID: 17020950
DOI: 10.1128/jvi.01325-06
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17093192
Title: GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS.
PubMed ID: 17093192
DOI: 10.1128/jvi.02076-06
PubMed ID: 17438296
Title: Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor.
PubMed ID: 17438296
PubMed ID: 17460044
Title: Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
PubMed ID: 17460044
PubMed ID: 17600090
Title: Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.
PubMed ID: 17600090
PubMed ID: 17709747
Title: The Atg5-Atg12 conjugate associates with innate antiviral immune responses.
PubMed ID: 17709747
PubMed ID: 18636086
Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
PubMed ID: 18636086
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18200010
Title: NLRX1 is a regulator of mitochondrial antiviral immunity.
PubMed ID: 18200010
DOI: 10.1038/nature06501
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19631370
Title: RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.
PubMed ID: 19631370
PubMed ID: 19419966
Title: The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.
PubMed ID: 19419966
PubMed ID: 19734229
Title: Negative regulation of MAVS-mediated innate immune response by PSMA7.
PubMed ID: 19734229
PubMed ID: 19881509
Title: PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
PubMed ID: 19881509
DOI: 10.1038/ni.1815
PubMed ID: 19164550
Title: Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria.
PubMed ID: 19164550
PubMed ID: 19416887
Title: ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
PubMed ID: 19416887
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20451243
Title: Peroxisomes are signaling platforms for antiviral innate immunity.
PubMed ID: 20451243
PubMed ID: 20628368
Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
PubMed ID: 20628368
DOI: 10.1038/cr.2010.103
PubMed ID: 20127681
Title: DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
PubMed ID: 20127681
PubMed ID: 21170385
Title: Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.
PubMed ID: 21170385
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21436888
Title: The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling.
PubMed ID: 21436888
PubMed ID: 21813773
Title: IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.
PubMed ID: 21813773
PubMed ID: 23087404
Title: Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.
PubMed ID: 23087404
PubMed ID: 22383950
Title: Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection.
PubMed ID: 22383950
PubMed ID: 23711367
Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.
PubMed ID: 23711367
PubMed ID: 23399697
Title: Mitochondrially localised MUL1 is a novel modulator of antiviral signaling.
PubMed ID: 23399697
DOI: 10.1038/icb.2013.7
PubMed ID: 23545497
Title: UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS.
PubMed ID: 23545497
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23582325
Title: The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.
PubMed ID: 23582325
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24390337
Title: Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
PubMed ID: 24390337
DOI: 10.1128/jvi.02712-13
PubMed ID: 25135833
Title: SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome.
PubMed ID: 25135833
PubMed ID: 25636800
Title: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
PubMed ID: 25636800
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 25228397
Title: ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.
PubMed ID: 25228397
DOI: 10.1159/000365971
PubMed ID: 27980081
Title: DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.
PubMed ID: 27980081
DOI: 10.1042/bcj20160956
PubMed ID: 27736772
Title: TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.
PubMed ID: 27736772
DOI: 10.1128/mcb.00422-16
PubMed ID: 28011935
Title: TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.
PubMed ID: 28011935
PubMed ID: 28566380
Title: Seneca Valley virus suppresses host type I interferon production by targeting adaptor proteins MAVS, TRIF, and TANK for cleavage.
PubMed ID: 28566380
DOI: 10.1128/jvi.00823-17
PubMed ID: 27992402
Title: The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination.
PubMed ID: 27992402
DOI: 10.1038/ni.3641
PubMed ID: 28253362
Title: Correction: Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses.
PubMed ID: 28253362
PubMed ID: 28414768
Title: GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
PubMed ID: 28414768
PubMed ID: 29743353
Title: TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS.
PubMed ID: 29743353
DOI: 10.1128/jvi.00321-18
PubMed ID: 31522117
Title: Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region.
PubMed ID: 31522117
PubMed ID: 31390091
Title: TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
PubMed ID: 31390091
PubMed ID: 30878284
Title: Apoptotic caspases suppress type i interferon production via the cleavage of cGAS, MAVS, and IRF3.
PubMed ID: 30878284
PubMed ID: 32321811
Title: The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling.
PubMed ID: 32321811
DOI: 10.1128/jvi.00454-20
PubMed ID: 33232374
Title: Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation.
PubMed ID: 33232374
PubMed ID: 34880843
Title: N4BP3 Regulates RIG-I-Like Receptor Antiviral Signaling Positively by Targeting Mitochondrial Antiviral Signaling Protein.
PubMed ID: 34880843
PubMed ID: 24569476
Title: Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
PubMed ID: 24569476
DOI: 10.7554/elife.01489
PubMed ID: 33110251
Title: SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response.
PubMed ID: 33110251
PubMed ID: 36943869
Title: UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS.
PubMed ID: 36943869
PubMed ID: 37311461
Title: An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
PubMed ID: 37311461
PubMed ID: 37582970
Title: MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade.
PubMed ID: 37582970
PubMed ID: 37656786
Title: MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion.
PubMed ID: 37656786
PubMed ID: 25018021
Title: Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
PubMed ID: 25018021
PubMed ID: 27302953
Title: Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
PubMed ID: 27302953
Sequence Information:
- Length: 540
- Mass: 56528
- Checksum: 0E23E3E115941EE8
- Sequence:
MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.