Details for: GPR158

Gene ID: 57512

Symbol: GPR158

Ensembl ID: ENSG00000151025

Description: G protein-coupled receptor 158

Associated with

Other Information

Genular Protein ID: 1168170714

Symbol: MGLYR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 18655026

Title: Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells.

PubMed ID: 18655026

DOI: 10.1002/pmic.200700887

PubMed ID: 23451275

Title: GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role.

PubMed ID: 23451275

DOI: 10.1371/journal.pone.0057843

PubMed ID: 30855200

Title: GPR158 in the visual system: homeostatic role in regulation of intraocular pressure.

PubMed ID: 30855200

DOI: 10.1089/jop.2018.0135

PubMed ID: 31189666

Title: Nonclassical ligand-independent regulation of Go protein by an orphan class C G-protein-coupled receptor.

PubMed ID: 31189666

DOI: 10.1124/mol.118.113019

PubMed ID: 36996198

Title: Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.

PubMed ID: 36996198

DOI: 10.1126/science.add7150

PubMed ID: 34815401

Title: Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gbeta5.

PubMed ID: 34815401

DOI: 10.1038/s41467-021-27147-1

PubMed ID: 34793198

Title: Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gbeta5 signaling complex.

PubMed ID: 34793198

DOI: 10.1126/science.abl4732

Sequence Information:

  • Length: 1215
  • Mass: 135489
  • Checksum: E0B565E573B3ADE1
  • Sequence:
  • MGAMAYPLLL CLLLAQLGLG AVGASRDPQG RPDSPRERTP KGKPHAQQPG RASASDSSAP 
    WSRSTDGTIL AQKLAEEVPM DVASYLYTGD SHQLKRANCS GRYELAGLPG KWPALASAHP 
    SLHRALDTLT HATNFLNVML QSNKSREQNL QDDLDWYQAL VWSLLEGEPS ISRAAITFST 
    DSLSAPAPQV FLQATREESR ILLQDLSSSA PHLANATLET EWFHGLRRKW RPHLHRRGPN 
    QGPRGLGHSW RRKDGLGGDK SHFKWSPPYL ECENGSYKPG WLVTLSSAIY GLQPNLVPEF 
    RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY ECICKAGFYH 
    PGVLPVNNFR RRGPDQHISG STKDVSEEAY VCLPCREGCP FCADDSPCFV QEDKYLRLAI 
    ISFQALCMLL DFVSMLVVYH FRKAKSIRAS GLILLETILF GSLLLYFPVV ILYFEPSTFR 
    CILLRWARLL GFATVYGTVT LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVILLVVFWF 
    LIGWTSSVCQ NLEKQISLIG QGKTSDHLIF NMCLIDRWDY MTAVAEFLFL LWGVYLCYAV 
    RTVPSAFHEP RYMAVAVHNE LIISAIFHTI RFVLASRLQS DWMLMLYFAH THLTVTVTIG 
    LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI NSAWSEHSLD PEDIRDELKK 
    LYAQLEIYKR KKMITNNPHL QKKRCSKKGL GRSIMRRITE IPETVSRQCS KEDKEGADHG 
    TAKGTALIRK NPPESSGNTG KSKEETLKNR VFSLKKSHST YDHVRDQTEE SSSLPTESQE 
    EETTENSTLE SLSGKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK TGHPRTSMLQ 
    KSLSVIASAK EKTLGLAGKT QTAGVEERTK SQKPLPKDKE TNRNHSNSDN TETKDPAPQN 
    SNPAEEPRKP QKSGIMKQQR VNPTTANSDL NPGTTQMKDN FDIGEVCPWE VYDLTPGPVP 
    SESKVQKHVS IVASEMEKNP TFSLKEKSHH KPKAAEVCQQ SNQKRIDKAE VCLWESQGQS 
    ILEDEKLLIS KTPVLPERAK EENGGQPRAA NVCAGQSEEL PPKAVASKTE NENLNQIGHQ 
    EKKTSSSEEN VRGSYNSSNN FQQPLTSRAE VCPWEFETPA QPNAGRSVAL PASSALSANK 
    IAGPRKEEIW DSFKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.