Details for: HECW2

Gene ID: 57520

Symbol: HECW2

Ensembl ID: ENSG00000138411

Description: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

Associated with

Other Information

Genular Protein ID: 2682271049

Symbol: HECW2_HUMAN

Name: E3 ubiquitin-protein ligase HECW2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12890487

Title: A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity.

PubMed ID: 12890487

DOI: 10.1016/s0006-291x(03)01347-0

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24163370

Title: The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

PubMed ID: 24163370

DOI: 10.1074/jbc.m113.472076

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27389779

Title: De novo missense variants in HECW2 are associated with neurodevelopmental delay and hypotonia.

PubMed ID: 27389779

DOI: 10.1136/jmedgenet-2016-103943

Sequence Information:

  • Length: 1572
  • Mass: 175769
  • Checksum: DCFF0146ADFAF8BE
  • Sequence:
  • MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS 
    LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 
    IVWRIEPGPY FMEPEIKICF KYYHGISGAL RATTPCITVK NPAVMMGAEG MEGGASGNLH 
    SRKLVSFTLS DLRAVGLKKG MFFNPDPYLK MSIQPGKKSS FPTCAHHGQE RRSTIISNTT 
    NPIWHREKYS FFALLTDVLE IEIKDKFAKS RPIIKRFLGK LTIPVQRLLE RQAIGDQMLS 
    YNLGRRLPAD HVSGYLQFKV EVTSSVHEDA SPEAVGTILG VNSVNGDLGS PSDDEDMPGS 
    HHDSQVCSNG PVSEDSAADG TPKHSFRTSS TLEIDTEELT STSSRTSPPR GRQDSLNDYL 
    DAIEHNGHSR PGTATCSERS MGASPKLRSS FPTDTRLNAM LHIDSDEEDH EFQQDLGYPS 
    SLEEEGGLIM FSRASRADDG SLTSQTKLED NPVENEEAST HEAASFEDKP ENLPELAESS 
    LPAGPAPEEG EGGPEPQPSA DQGSAELCGS QEVDQPTSGA DTGTSDASGG SRRAVSETES 
    LDQGSEPSQV SSETEPSDPA RTESVSEAST RPEGESDLEC ADSSCNESVT TQLSSVDTRC 
    SSLESARFPE TPAFSSQEEE DGACAAEPTS SGPAEGSQES VCTAGSLPVV QVPSGEDEGP 
    GAESATVPDQ EELGEVWQRR GSLEGAAAAA ESPPQEEGSA GEAQGTCEGA TAQEEGATGG 
    SQANGHQPLR SLPSVRQDVS RYQRVDEALP PNWEARIDSH GRIFYVDHVN RTTTWQRPTA 
    PPAPQVLQRS NSIQQMEQLN RRYQSIRRTM TNERPEENTN AIDGAGEEAD FHQASADFRR 
    ENILPHSTSR SRITLLLQSP PVKFLISPEF FTVLHSNPSA YRMFTNNTCL KHMITKVRRD 
    THHFERYQHN RDLVGFLNMF ANKQLELPRG WEMKHDHQGK AFFVDHNSRT TTFIDPRLPL 
    QSSRPTSALV HRQHLTRQRS HSAGEVGEDS RHAGPPVLPR PSSTFNTVSR PQYQDMVPVA 
    YNDKIVAFLR QPNIFEILQE RQPDLTRNHS LREKIQFIRT EGTPGLVRLS SDADLVMLLS 
    LFEEEIMSYV PPHALLHPSY CQSPRGSPVS SPQNSPGTQR ANARAPAPYK RDFEAKLRNF 
    YRKLETKGYG QGPGKLKLII RRDHLLEDAF NQIMGYSRKD LQRNKLYVTF VGEEGLDYSG 
    PSREFFFLVS RELFNPYYGL FEYSANDTYT VQISPMSAFV DNHHEWFRFS GRILGLALIH 
    QYLLDAFFTR PFYKALLRIL CDLSDLEYLD EEFHQSLQWM KDNDIHDILD LTFTVNEEVF 
    GQITERELKP GGANIPVTEK NKKEYIERMV KWRIERGVVQ QTESLVRGFY EVVDARLVSV 
    FDARELELVI AGTAEIDLSD WRNNTEYRGG YHDNHIVIRW FWAAVERFNN EQRLRLLQFV 
    TGTSSIPYEG FASLRGSNGP RRFCVEKWGK ITALPRAHTC FNRLDLPPYP SFSMLYEKLL 
    TAVEETSTFG LE

Genular Protein ID: 2936802887

Symbol: A0A2R8Y6F3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1579
  • Mass: 176601
  • Checksum: D20E6CFC4547695D
  • Sequence:
  • MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS 
    LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 
    IVWRIEPGPY FMEPEIKICF KYYHGISGAL RATTPCITVK NPAVMMGAEG MEGGASGNLH 
    SRKLVSFTLS DLRAVGLKKG MFFNPDPYLK MSIQPGKKSS FPTCAHHGQE RRSTIISNTT 
    NPIWHREKYS FFALLTDVLE IEIKDKFAKS RPIIKRFLGK LTIPVQRLLE RQAIGDQMLS 
    YNLGRRLPAD HVSGYLQFKV EVTSSVHEEM LFSHSDASPE AVGTILGVNS VNGDLGSPSD 
    DEDMPGSHHD SQVCSNGPVS EDSAADGTPK HSFRTSSTLE IDTEELTSTS SRTSPPRGRQ 
    DSLNDYLDAI EHNGHSRPGT ATCSERSMGA SPKLRSSFPT DTRLNAMLHI DSDEEDHEFQ 
    QDLGYPSSLE EEGGLIMFSR ASRADDGSLT SQTKLEDNPV ENEEASTHEA ASFEDKPENL 
    PELAESSLPA GPAPEEGEGG PEPQPSADQG SAELCGSQEV DQPTSGADTG TSDASGGSRR 
    AVSETESLDQ GSEPSQVSSE TEPSDPARTE SVSEASTRPE GESDLECADS SCNESVTTQL 
    SSVDTRCSSL ESARFPETPA FSSQEEEDGA CAAEPTSSGP AEGSQESVCT AGSLPVVQVP 
    SGEDEGPGAE SATVPDQEEL GEVWQRRGSL EGAAAAAESP PQEEGSAGEA QGTCEGATAQ 
    EEGATGGSQA NGHQPLRSLP SVRQDVSRYQ RVDEALPPNW EARIDSHGRI FYVDHVNRTT 
    TWQRPTAPPA PQVLQRSNSI QQMEQLNRRY QSIRRTMTNE RPEENTNAID GAGEEADFHQ 
    ASADFRRENI LPHSTSRSRI TLLLQSPPVK FLISPEFFTV LHSNPSAYRM FTNNTCLKHM 
    ITKVRRDTHH FERYQHNRDL VGFLNMFANK QLELPRGWEM KHDHQGKAFF VDHNSRTTTF 
    IDPRLPLQSS RPTSALVHRQ HLTRQRSHSA GEVGEDSRHA GPPVLPRPSS TFNTVSRPQY 
    QDMVPVAYND KIVAFLRQPN IFEILQERQP DLTRNHSLRE KIQFIRTEGT PGLVRLSSDA 
    DLVMLLSLFE EEIMSYVPPH ALLHPSYCQS PRGSPVSSPQ NSPGTQRANA RAPAPYKRDF 
    EAKLRNFYRK LETKGYGQGP GKLKLIIRRD HLLEDAFNQI MGYSRKDLQR NKLYVTFVGE 
    EGLDYSGPSR EFFFLVSREL FNPYYGLFEY SANDTYTVQI SPMSAFVDNH HEWFRFSGRI 
    LGLALIHQYL LDAFFTRPFY KALLRILCDL SDLEYLDEEF HQSLQWMKDN DIHDILDLTF 
    TVNEEVFGQI TERELKPGGA NIPVTEKNKK EYIERMVKWR IERGVVQQTE SLVRGFYEVV 
    DARLVSVFDA RELELVIAGT AEIDLSDWRN NTEYRGGYHD NHIVIRWFWA AVERFNNEQR 
    LRLLQFVTGT SSIPYEGFAS LRGSNGPRRF CVEKWGKITA LPRAHTCFNR LDLPPYPSFS 
    MLYEKLLTAV EETSTFGLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.