Details for: RPTOR

Gene ID: 57521

Symbol: RPTOR

Ensembl ID: ENSG00000141564

Description: regulatory associated protein of MTOR complex 1

Associated with

Other Information

Genular Protein ID: 792749646

Symbol: RPTOR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N122 B2RN36 C6KEF2 F5H7J5 Q8N4V9 Q8TB32 Q9P2P3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 7 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 14 EMDB 16 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 14 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12150925

Title: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery.

PubMed ID: 12150925

DOI: 10.1016/s0092-8674(02)00808-5

PubMed ID: 12150926

Title: Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

PubMed ID: 12150926

DOI: 10.1016/s0092-8674(02)00833-4

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 19388141

Title: Characterization of a novel splicing variant in the RAPTOR gene.

PubMed ID: 19388141

DOI: 10.1016/j.mrfmmm.2009.01.001

PubMed ID: 12408816

Title: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

PubMed ID: 12408816

DOI: 10.1016/s1097-2765(02)00636-6

PubMed ID: 12747827

Title: TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

PubMed ID: 12747827

DOI: 10.1016/s0960-9822(03)00329-4

PubMed ID: 15066126

Title: Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.

PubMed ID: 15066126

DOI: 10.1111/j.1356-9597.2004.00727.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17386266

Title: PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

PubMed ID: 17386266

DOI: 10.1016/j.molcel.2007.03.003

PubMed ID: 18722121

Title: Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.

PubMed ID: 18722121

DOI: 10.1016/j.cub.2008.07.078

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18439900

Title: AMPK phosphorylation of raptor mediates a metabolic checkpoint.

PubMed ID: 18439900

DOI: 10.1016/j.molcel.2008.03.003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19211835

Title: Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

PubMed ID: 19211835

DOI: 10.1091/mbc.e08-12-1248

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 19864431

Title: Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.

PubMed ID: 19864431

DOI: 10.1074/jbc.m109.029637

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23027611

Title: 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

PubMed ID: 23027611

DOI: 10.1002/emmm.201201410

PubMed ID: 22493283

Title: Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation.

PubMed ID: 22493283

DOI: 10.1074/jbc.m111.326538

PubMed ID: 23953116

Title: Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.

PubMed ID: 23953116

DOI: 10.1016/j.cell.2013.07.031

PubMed ID: 24036451

Title: PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.

PubMed ID: 24036451

DOI: 10.1016/j.febslet.2013.09.001

PubMed ID: 25657994

Title: The potential role of BRCA1-associated ATM activator-1 (BRAT1) in regulation of mTOR.

PubMed ID: 25657994

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24403073

Title: Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.

PubMed ID: 24403073

DOI: 10.1074/jbc.m113.482067

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26588989

Title: NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.

PubMed ID: 26588989

DOI: 10.1101/gad.265116.115

PubMed ID: 25940091

Title: La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1).

PubMed ID: 25940091

DOI: 10.1074/jbc.m114.621730

PubMed ID: 26812014

Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.

PubMed ID: 26812014

DOI: 10.1016/j.devcel.2015.12.019

PubMed ID: 30078703

Title: Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.

PubMed ID: 30078703

DOI: 10.1016/j.cell.2018.06.053

PubMed ID: 30232230

Title: The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.

PubMed ID: 30232230

DOI: 10.1126/scitranslmed.aat9356

PubMed ID: 30197302

Title: Leucine signals to mTORC1 via its metabolite acetyl-coenzyme A.

PubMed ID: 30197302

DOI: 10.1016/j.cmet.2018.08.013

PubMed ID: 31112131

Title: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

PubMed ID: 31112131

DOI: 10.7554/elife.43038

PubMed ID: 31530866

Title: TBK1 limits mTORC1 by promoting phosphorylation of Raptor Ser877.

PubMed ID: 31530866

DOI: 10.1038/s41598-019-49707-8

PubMed ID: 32561715

Title: Leucine regulates autophagy via acetylation of the mTORC1 component raptor.

PubMed ID: 32561715

DOI: 10.1038/s41467-020-16886-2

PubMed ID: 34290272

Title: VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma.

PubMed ID: 34290272

DOI: 10.1038/s41598-021-94132-5

PubMed ID: 35561222

Title: SNAT7 regulates mTORC1 via macropinocytosis.

PubMed ID: 35561222

DOI: 10.1073/pnas.2123261119

PubMed ID: 35927303

Title: Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.

PubMed ID: 35927303

DOI: 10.1038/s41418-022-01047-3

PubMed ID: 37541260

Title: O-GlcNAcylation of Raptor transduces glucose signals to mTORC1.

PubMed ID: 37541260

DOI: 10.1016/j.molcel.2023.07.011

PubMed ID: 27909983

Title: 4.4 Aa Resolution Cryo-EM structure of human mTOR Complex 1.

PubMed ID: 27909983

DOI: 10.1007/s13238-016-0346-6

PubMed ID: 29236692

Title: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

PubMed ID: 29236692

DOI: 10.1038/nature25023

PubMed ID: 31601764

Title: Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

PubMed ID: 31601764

DOI: 10.1126/science.aax3939

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 34519269

Title: Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.

PubMed ID: 34519269

DOI: 10.7554/elife.68799

PubMed ID: 34519268

Title: Regulation of human mTOR complexes by DEPTOR.

PubMed ID: 34519268

DOI: 10.7554/elife.70871

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

Sequence Information:

  • Length: 1335
  • Mass: 149038
  • Checksum: 688ED1943F45045A
  • Sequence:
    • MESEMLQSPL LGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR MKDRMKTVSV 
ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE TIGANLQKQY ENWQPRARYK 
QSLDPTVDEV KKLCTSLRRN AKEERVLFHY NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY 
DLQTWMGSPS IFVYDCSNAG LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC 
IQLAACEATE LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG 
RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF LLAERIMRSY 
NCTPVSSPRL PPTYMHAMWQ AWDLAVDICL SQLPTIIEEG TAFRHSPFFA EQLTAFQVWL 
TMGVENRNPP EQLPIVLQVL LSQVHRLRAL DLLGRFLDLG PWAVSLALSV GIFPYVLKLL 
QSSARELRPL LVFIWAKILA VDSSCQADLV KDNGHKYFLS VLADPYMPAE HRTMTAFILA 
VIVNSYHTGQ EACLQGNLIA ICLEQLNDPH PLLRQWVAIC LGRIWQNFDS ARWCGVRDSA 
HEKLYSLLSD PIPEVRCAAV FALGTFVGNS AERTDHSTTI DHNVAMMLAQ LVSDGSPMVR 
KELVVALSHL VVQYESNFCT VALQFIEEEK NYALPSPATT EGGSLTPVRD SPCTPRLRSV 
SSYGNIRAVA TARSLNKSLQ NLSLTEESGG AVAFSPGNLS TSSSASSTLG SPENEEHILS 
FETIDKMRRA SSYSSLNSLI GVSFNSVYTQ IWRVLLHLAA DPYPEVSDVA MKVLNSIAYK 
ATVNARPQRV LDTSSLTQSA PASPTNKGVH IHQAGGSPPA SSTSSSSLTN DVAKQPVSRD 
LPSGRPGTTG PAGAQYTPHS HQFPRTRKMF DKGPEQTADD ADDAAGHKSF ISATVQTGFC 
DWSARYFAQP VMKIPEEHDL ESQIRKEREW RFLRNSRVRR QAQQVIQKGI TRLDDQIFLN 
RNPGVPSVVK FHPFTPCIAV ADKDSICFWD WEKGEKLDYF HNGNPRYTRV TAMEYLNGQD 
CSLLLTATDD GAIRVWKNFA DLEKNPEMVT AWQGLSDMLP TTRGAGMVVD WEQETGLLMS 
SGDVRIVRIW DTDREMKVQD IPTGADSCVT SLSCDSHRSL IVAGLGDGSI RVYDRRMALS 
ECRVMTYREH TAWVVKASLQ KRPDGHIVSV SVNGDVRIFD PRMPESVNVL QIVKGLTALD 
IHPQADLIAC GSVNQFTAIY NSSGELINNI KYYDGFMGQR VGAISCLAFH PHWPHLAVGS 
NDYYISVYSV EKRVR

Genular Protein ID: 1850069426

Symbol: Q6DKI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6DKI0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 130
  • Mass: 14531
  • Checksum: F338EEAD98162224
  • Sequence:
    • TYREHTAWVV KASLQKRPDG HIVSVSVNGD VRIFDPRMPE SVNVLQIVKG LTALDIHPQA 
DLIACGSVNQ FTAIYNSSGE LINNIKYYDG FMGQRVGAIS CLAFHPHWPH LAVGSNDYYI 
SVYSVEKRVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.