PTK6 | ENSG00000101213 | NCBI 5753

Details for: PTK6

Gene ID: 5753

Symbol: PTK6

Ensembl ID: ENSG00000101213

Description: protein tyrosine kinase 6

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytoprotection by hmox1
(R-HSA-9707564)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Ptk6 activates stat3
(R-HSA-8849474)
Ptk6 down-regulation
(R-HSA-8849472)
Ptk6 expression
(R-HSA-8849473)
Ptk6 promotes hif1a stabilization
(R-HSA-8857538)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Ptk6 regulates proteins involved in rna processing
(R-HSA-8849468)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Ptk6 regulates rtks and their effectors akt1 and dok1
(R-HSA-8849469)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Signaling by erbb2
(R-HSA-1227986)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Atp binding
(GO:0005524)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cellular response to retinoic acid
(GO:0071300)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Erbb2 signaling pathway
(GO:0038128)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Intestinal epithelial cell differentiation
(GO:0060575)
Negative regulation of growth
(GO:0045926)
Negative regulation of protein tyrosine kinase activity
(GO:0061099)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Ruffle
(GO:0001726)
Signaling receptor binding
(GO:0005102)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Protein-tyrosine kinase 6

Genular Protein ID: 3040730797

Symbol: PTK6_HUMAN

Name: Protein-tyrosine kinase 6

UniProtKB Accession Codes:

Q13882 B2RCR3 B4DW46 Q58F01

Database IDs:

Citations:

PubMed ID: 8036022

Title: Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours.

PubMed ID: 8036022

PubMed ID: 9333026

Title: Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk.

PubMed ID: 9333026

DOI: 10.1038/sj.onc.1201292

PubMed ID: 9749526

Title: Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase.

PubMed ID: 9749526

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8940083

Title: Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor.

PubMed ID: 8940083

DOI: 10.1074/jbc.271.48.30956

PubMed ID: 9185712

Title: Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma.

PubMed ID: 9185712

DOI: 10.1002/(sici)1097-0215(19970611)71:6<1061::aid-ijc24>3.0.co;2-f

PubMed ID: 10980601

Title: A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK.

PubMed ID: 10980601

DOI: 10.1038/sj.onc.1203775

PubMed ID: 10913193

Title: Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.

PubMed ID: 10913193

DOI: 10.1128/mcb.20.16.6114-6126.2000

PubMed ID: 12121988

Title: Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition.

PubMed ID: 12121988

DOI: 10.1074/jbc.m203877200

PubMed ID: 12833144

Title: Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells.

PubMed ID: 12833144

DOI: 10.1038/sj.onc.1206465

PubMed ID: 15471878

Title: The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

PubMed ID: 15471878

DOI: 10.1074/jbc.m409579200

PubMed ID: 15572663

Title: Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin.

PubMed ID: 15572663

DOI: 10.1128/mcb.24.24.10558-10572.2004

PubMed ID: 15509496

Title: Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium.

PubMed ID: 15509496

DOI: 10.1016/j.oraloncology.2004.05.010

PubMed ID: 15539407

Title: Regulated association of protein kinase B/Akt with breast tumor kinase.

PubMed ID: 15539407

DOI: 10.1074/jbc.m412038200

PubMed ID: 15961400

Title: An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.

PubMed ID: 15961400

DOI: 10.1074/jbc.m504568200

PubMed ID: 16179349

Title: Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.

PubMed ID: 16179349

DOI: 10.1074/jbc.m505802200

PubMed ID: 15870689

Title: Interaction between Brk kinase and insulin receptor substrate-4.

PubMed ID: 15870689

DOI: 10.1038/sj.onc.1208721

PubMed ID: 16651629

Title: Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

PubMed ID: 16651629

DOI: 10.2353/ajpath.2006.050521

PubMed ID: 16568091

Title: Identification of STAT3 as a specific substrate of breast tumor kinase.

PubMed ID: 16568091

DOI: 10.1038/sj.onc.1209501

PubMed ID: 17822667

Title: Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6.

PubMed ID: 17822667

DOI: 10.1016/j.bbrc.2007.08.055

PubMed ID: 17997837

Title: Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6.

PubMed ID: 17997837

DOI: 10.1186/bcr1794

PubMed ID: 18829532

Title: Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.

PubMed ID: 18829532

DOI: 10.1158/0008-5472.can-08-0997

PubMed ID: 18296648

Title: Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

PubMed ID: 18296648

DOI: 10.1158/1541-7786.mcr-07-2028

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18719096

Title: Brk is coamplified with ErbB2 to promote proliferation in breast cancer.

PubMed ID: 18719096

DOI: 10.1073/pnas.0805009105

PubMed ID: 19439179

Title: BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.

PubMed ID: 19439179

DOI: 10.1016/j.cellsig.2009.04.008

PubMed ID: 20193745

Title: Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.

PubMed ID: 20193745

DOI: 10.1016/j.bbcan.2010.02.003

PubMed ID: 20026641

Title: Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.

PubMed ID: 20026641

DOI: 10.1242/jcs.053264

PubMed ID: 21479203

Title: The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of beta-catenin.

PubMed ID: 21479203

DOI: 10.1371/journal.pone.0014789

PubMed ID: 15056653

Title: Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain.

PubMed ID: 15056653

DOI: 10.1074/jbc.m313185200

PubMed ID: 27480927

Title: Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 A resolution.

PubMed ID: 27480927

DOI: 10.1016/j.bbrc.2016.07.121

PubMed ID: 27993680

Title: Co-crystal structures of PTK6: With Dasatinib at 2.24 A, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 A resolution.

PubMed ID: 27993680

DOI: 10.1016/j.bbrc.2016.12.030

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 451
Mass: 51834
Checksum: CDCAC0EE242E1BD7
Sequence:

MVSRDQAHLG PKYVGLWDFK SRTDEELSFR AGDVFHVARK EEQWWWATLL DEAGGAVAQG 
YVPHNYLAER ETVESEPWFF GCISRSEAVR RLQAEGNATG AFLIRVSEKP SADYVLSVRD 
TQAVRHYKIW RRAGGRLHLN EAVSFLSLPE LVNYHRAQSL SHGLRLAAPC RKHEPEPLPH 
WDDWERPREE FTLCRKLGSG YFGEVFEGLW KDRVQVAIKV ISRDNLLHQQ MLQSEIQAMK 
KLRHKHILAL YAVVSVGDPV YIITELMAKG SLLELLRDSD EKVLPVSELL DIAWQVAEGM 
CYLESQNYIH RDLAARNILV GENTLCKVGD FGLARLIKED VYLSHDHNIP YKWTAPEALS 
RGHYSTKSDV WSFGILLHEM FSRGQVPYPG MSNHEAFLRV DAGYRMPCPL ECPPSVHKLM 
LTCWCRDPEQ RPCFKALRER LSSFTSYENP T

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PTK6

Associated with

Other Information

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. PubMed ID: 8036022

Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk. PubMed ID: 9333026

Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. PubMed ID: 9749526

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. PubMed ID: 8940083

Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. PubMed ID: 9185712

A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. PubMed ID: 10980601

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. PubMed ID: 10913193

Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. PubMed ID: 12121988

Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. PubMed ID: 12833144

The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. PubMed ID: 15471878

Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. PubMed ID: 15572663

Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium. PubMed ID: 15509496

Regulated association of protein kinase B/Akt with breast tumor kinase. PubMed ID: 15539407

An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6. PubMed ID: 15961400

Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. PubMed ID: 16179349

Interaction between Brk kinase and insulin receptor substrate-4. PubMed ID: 15870689

Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. PubMed ID: 16651629

Identification of STAT3 as a specific substrate of breast tumor kinase. PubMed ID: 16568091

Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6. PubMed ID: 17822667

Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. PubMed ID: 17997837

Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. PubMed ID: 18829532

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. PubMed ID: 18296648

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Brk is coamplified with ErbB2 to promote proliferation in breast cancer. PubMed ID: 18719096

BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. PubMed ID: 19439179

Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK. PubMed ID: 20193745

Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. PubMed ID: 20026641

The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of beta-catenin. PubMed ID: 21479203

Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain. PubMed ID: 15056653

Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 A resolution. PubMed ID: 27480927

Co-crystal structures of PTK6: With Dasatinib at 2.24 A, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 A resolution. PubMed ID: 27993680

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846