MIB1 | ENSG00000101752 | NCBI 57534

Details for: MIB1

Gene ID: 57534

Symbol: MIB1

Ensembl ID: ENSG00000101752

Description: MIB E3 ubiquitin protein ligase 1

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 hd domain mutants
(R-HSA-2691232)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Notch2 activation and transmission of signal to the nucleus
(R-HSA-2979096)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 hd domain mutants in cancer
(R-HSA-2691230)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signal transduction
(R-HSA-162582)
Blood vessel development
(GO:0001568)
Centriolar satellite
(GO:0034451)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Heart looping
(GO:0001947)
In utero embryonic development
(GO:0001701)
Negative regulation of neuron differentiation
(GO:0045665)
Neural tube formation
(GO:0001841)
Neuron differentiation
(GO:0030182)
Notch signaling pathway
(GO:0007219)
Plasma membrane
(GO:0005886)
Positive regulation of endocytosis
(GO:0045807)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Somitogenesis
(GO:0001756)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase MIB1

Genular Protein ID: 106701654

Symbol: MIB1_HUMAN

Name: E3 ubiquitin-protein ligase MIB1

UniProtKB Accession Codes:

Q86YT6 B0YJ38 Q2TB37 Q68D01 Q6YI51 Q8NBY0 Q8TCB5 Q8TCL7 Q9P2M3

Database IDs:

Citations:

PubMed ID: 12530964

Title: Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

PubMed ID: 12530964

DOI: 10.1016/s1534-5807(02)00409-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15048887

Title: Death-associated protein kinase expression in human temporal lobe epilepsy.

PubMed ID: 15048887

DOI: 10.1002/ana.20001

PubMed ID: 21903422

Title: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

PubMed ID: 21903422

DOI: 10.1016/j.immuni.2011.06.014

PubMed ID: 24121310

Title: A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis.

PubMed ID: 24121310

DOI: 10.1038/emboj.2013.223

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23314057

Title: Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.

PubMed ID: 23314057

DOI: 10.1038/nm.3046

PubMed ID: 31851912

Title: The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex.

PubMed ID: 31851912

DOI: 10.1016/j.celrep.2019.11.064

Sequence Information:

Length: 1006
Mass: 110136
Checksum: 5D7D0D91AF98FF18
Sequence:

MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV VWDNGTAANY 
RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC AECTNYDLCT VCYHGDKHHL 
RHRFYRITTP GSERVLLESR RKSKKITARG IFAGARVVRG VDWQWEDQDG GNGRRGKVTE 
IQDWSASSPH SAAYVLWDNG AKNLYRVGFE GMSDLKCVQD AKGGSFYRDH CPVLGEQNGN 
RNPGGLQIGD LVNIDLDLEI VQSLQHGHGG WTDGMFETLT TTGTVCGIDE DHDIVVQYPS 
GNRWTFNPAV LTKANIVRSG DAAQGAEGGT SQFQVGDLVQ VCYDLERIKL LQRGHGEWAE 
AMLPTLGKVG RVQQIYSDSD LKVEVCGTSW TYNPAAVSKV ASAGSAISNA SGERLSQLLK 
KLFETQESGD LNEELVKAAA NGDVAKVEDL LKRPDVDVNG QCAGHTAMQA ASQNGHVDIL 
KLLLKQNVDV EAEDKDGDRA VHHAAFGDEG AVIEVLHRGS ADLNARNKRR QTPLHIAVNK 
GHLQVVKTLL DFGCHPSLQD SEGDTPLHDA ISKKRDDILA VLLEAGADVT ITNNNGFNAL 
HHAALRGNPS AMRVLLSKLP RPWIVDEKKD DGYTALHLAA LNNHVEVAEL LVHQGNANLD 
IQNVNQQTAL HLAVERQHTQ IVRLLVRAGA KLDIQDKDGD TPLHEALRHH TLSQLRQLQD 
MQDVGKVDAA WEPSKNTLIM GLGTQGAEKK SAASIACFLA ANGADLSIRN KKGQSPLDLC 
PDPNLCKALA KCHKEKVSGQ VGSRSPSMIS NDSETLEECM VCSDMKRDTL FGPCGHIATC 
SLCSPRVKKC LICKEQVQSR TKIEECVVCS DKKAAVLFQP CGHMCACENC ANLMKKCVQC 
RAVVERRVPF IMCCGGKSSE DATDDISSGN IPVLQKDKDN TNVNADVQKL QQQLQDIKEQ 
TMCPVCLDRL KNMIFLCGHG TCQLCGDRMS ECPICRKAIE RRILLY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MIB1

Associated with

Other Information

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. PubMed ID: 12530964

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10718198

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Death-associated protein kinase expression in human temporal lobe epilepsy. PubMed ID: 15048887

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. PubMed ID: 21903422

A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis. PubMed ID: 24121310

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. PubMed ID: 23314057

The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex. PubMed ID: 31851912