NLGN2 | ENSG00000169992 | NCBI 57555

Details for: NLGN2

Gene ID: 57555

Symbol: NLGN2

Ensembl ID: ENSG00000169992

Description: neuroligin 2

Associated with

Neurexins and neuroligins
(R-HSA-6794361)
Neuronal system
(R-HSA-112316)
Protein-protein interactions at synapses
(R-HSA-6794362)
Cell-cell adhesion
(GO:0098609)
Cell-cell junction maintenance
(GO:0045217)
Cell adhesion molecule binding
(GO:0050839)
Cell surface
(GO:0009986)
Chemical synaptic transmission
(GO:0007268)
Dendritic shaft
(GO:0043198)
Dopaminergic synapse
(GO:0098691)
Excitatory synapse
(GO:0060076)
Gephyrin clustering involved in postsynaptic density assembly
(GO:0097116)
Glycinergic synapse
(GO:0098690)
Identical protein binding
(GO:0042802)
Inhibitory synapse
(GO:0060077)
Inhibitory synapse assembly
(GO:1904862)
Insulin metabolic process
(GO:1901142)
Jump response
(GO:0007630)
Locomotory exploration behavior
(GO:0035641)
Membrane
(GO:0016020)
Modulation of chemical synaptic transmission
(GO:0050804)
Neurexin family protein binding
(GO:0042043)
Neuromuscular process controlling balance
(GO:0050885)
Neuron cell-cell adhesion
(GO:0007158)
Neurotransmitter-gated ion channel clustering
(GO:0072578)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dendritic spine development
(GO:0060999)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of inhibitory postsynaptic potential
(GO:0097151)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of protein localization to synapse
(GO:1902474)
Positive regulation of synapse assembly
(GO:0051965)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of synaptic vesicle clustering
(GO:2000809)
Positive regulation of t-snare clustering
(GO:1904034)
Postsynaptic density protein 95 clustering
(GO:0097119)
Postsynaptic membrane
(GO:0045211)
Postsynaptic membrane assembly
(GO:0097104)
Postsynaptic specialization membrane
(GO:0099634)
Presynapse assembly
(GO:0099054)
Presynaptic membrane
(GO:0042734)
Presynaptic membrane assembly
(GO:0097105)
Protein localization to cell surface
(GO:0034394)
Protein localization to synapse
(GO:0035418)
Regulation of ampa receptor activity
(GO:2000311)
Regulation of presynapse assembly
(GO:1905606)
Regulation of respiratory gaseous exchange by nervous system process
(GO:0002087)
Ribbon synapse
(GO:0097470)
Sensory perception of pain
(GO:0019233)
Signaling receptor activity
(GO:0038023)
Social behavior
(GO:0035176)
Symmetric, gaba-ergic, inhibitory synapse
(GO:0098983)
Synapse
(GO:0045202)
Synapse assembly
(GO:0007416)
Synapse organization
(GO:0050808)
Synaptic transmission, gabaergic
(GO:0051932)
Synaptic vesicle endocytosis
(GO:0048488)
Terminal button organization
(GO:0072553)
Thigmotaxis
(GO:0001966)

Other Information

Proteins

Neuroligin-2

Genular Protein ID: 444685542

Symbol: NLGN2_HUMAN

Name: Neuroligin-2

UniProtKB Accession Codes:

Q8NFZ4 Q9P2I1

Database IDs:

Citations:

PubMed ID: 12669065

Title: Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

PubMed ID: 12669065

DOI: 10.1038/ng1136

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 9278515

Title: Binding of neuroligins to PSD-95.

PubMed ID: 9278515

DOI: 10.1126/science.277.5331.1511

PubMed ID: 18755801

Title: Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion.

PubMed ID: 18755801

DOI: 10.1210/en.2008-0274

PubMed ID: 19926856

Title: The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.

PubMed ID: 19926856

DOI: 10.1073/pnas.0809510106

PubMed ID: 23751499

Title: The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.

PubMed ID: 23751499

DOI: 10.1083/jcb.201209132

Sequence Information:

Length: 835
Mass: 90820
Checksum: 359938630193EF87
Sequence:

MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR VRGVRRELNN 
EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT TLPPACPQNL HGALPAIMLP 
VWFTDNLEAA ATYVQNQSED CLYLNLYVPT EDGPLTKKRD EATLNPPDTD IRDPGKKPVM 
LFLHGGSYME GTGNMFDGSV LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ 
ALRWLSENIA HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV 
NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA FGPVVDGDVV 
PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG VSASAFDFTV SNFVDNLYGY 
PEGKDVLRET IKFMYTDWAD RDNGEMRRKT LLALFTDHQW VAPAVATAKL HADYQSPVYF 
YTFYHHCQAE GRPEWADAAH GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN 
FAKTGDPNQP VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF 
WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP PEPEPEPGPR 
AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK RDRRQELRCR RLSPPGGSGS 
GVPGGGPLLP AAGRELPPEE ELVSLQLKRG GGVGADPAEA LRPACPPDYT LALRRAPDDV 
PLLAPGALTL LPSGLGPPPP PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NLGN2

Associated with

Other Information

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. PubMed ID: 12669065

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10718198

Binding of neuroligins to PSD-95. PubMed ID: 9278515

Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. PubMed ID: 18755801

The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions. PubMed ID: 19926856