ARRDC3 | ENSG00000113369 | NCBI 57561

Details for: ARRDC3

Gene ID: 57561

Symbol: ARRDC3

Ensembl ID: ENSG00000113369

Description: arrestin domain containing 3

Associated with

Beta-3 adrenergic receptor binding
(GO:0031699)
Cytoplasm
(GO:0005737)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Fat pad development
(GO:0060613)
Heat generation
(GO:0031649)
Lysosome
(GO:0005764)
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071878)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of heat generation
(GO:0031651)
Negative regulation of locomotion involved in locomotory behavior
(GO:0090327)
Plasma membrane
(GO:0005886)
Positive regulation of hippo signaling
(GO:0035332)
Positive regulation of ubiquitin-protein transferase activity
(GO:0051443)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Skin development
(GO:0043588)

Other Information

Proteins

Arrestin domain-containing protein 3

Genular Protein ID: 893760784

Symbol: ARRD3_HUMAN

Name: Arrestin domain-containing protein 3

UniProtKB Accession Codes:

Q96B67 A8K6T8 Q9P2H1

Database IDs:

Citations:

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16269462

Title: Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling.

PubMed ID: 16269462

DOI: 10.1210/en.2005-0679

PubMed ID: 20559325

Title: Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

PubMed ID: 20559325

DOI: 10.1038/embor.2010.80

PubMed ID: 21982743

Title: The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

PubMed ID: 21982743

DOI: 10.1016/j.cmet.2011.08.011

PubMed ID: 21191027

Title: Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.

PubMed ID: 21191027

DOI: 10.1128/jvi.02045-10

PubMed ID: 23208550

Title: Distinct roles for beta-arrestin2 and arrestin-domain-containing proteins in beta2 adrenergic receptor trafficking.

PubMed ID: 23208550

DOI: 10.1038/embor.2012.187

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

PubMed ID: 24379409

Title: Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3).

PubMed ID: 24379409

DOI: 10.1074/jbc.m113.527473

PubMed ID: 25220262

Title: Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.

PubMed ID: 25220262

DOI: 10.1002/pro.2549

Sequence Information:

Length: 414
Mass: 46395
Checksum: 9B02190E1BA90B1D
Sequence:

MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT 
ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFHTIHSGRH EYAFSFELPQ 
TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT 
LCCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM 
KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD 
LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLSLSLP ERPEAPPSYA EVVTEEQRRN 
NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQSADDRPS CPSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARRDC3

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10718198

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. PubMed ID: 16269462

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. PubMed ID: 20559325

The arrestin domain-containing 3 protein regulates body mass and energy expenditure. PubMed ID: 21982743

Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. PubMed ID: 21191027

Distinct roles for beta-arrestin2 and arrestin-domain-containing proteins in beta2 adrenergic receptor trafficking. PubMed ID: 23208550

Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. PubMed ID: 23886940

Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). PubMed ID: 24379409

Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. PubMed ID: 25220262