Details for: KCNT1

Gene ID: 57582

Symbol: KCNT1

Ensembl ID: ENSG00000107147

Description: potassium sodium-activated channel subfamily T member 1

Associated with

  • Intracellular sodium-activated potassium channel activity
    (GO:0005228)
  • Outward rectifier potassium channel activity
    (GO:0015271)
  • Plasma membrane
    (GO:0005886)
  • Potassium ion transmembrane transport
    (GO:0071805)

Other Information

Genular Protein ID: 1466286584

Symbol: KCNT1_HUMAN

Name: Potassium channel subfamily T member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 20512134

Title: Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.

PubMed ID: 20512134

DOI: 10.1038/nn.2563

PubMed ID: 23086396

Title: Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy.

PubMed ID: 23086396

DOI: 10.1038/ng.2440

PubMed ID: 23086397

Title: De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy.

PubMed ID: 23086397

DOI: 10.1038/ng.2441

PubMed ID: 24029078

Title: A recurrent KCNT1 mutation in two sporadic cases with malignant migrating partial seizures in infancy.

PubMed ID: 24029078

DOI: 10.1016/j.gene.2013.08.096

PubMed ID: 23708187

Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

PubMed ID: 23708187

DOI: 10.1038/ng.2646

PubMed ID: 24463883

Title: Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis.

PubMed ID: 24463883

DOI: 10.1093/hmg/ddu030

PubMed ID: 26993267

Title: Improving diagnosis and broadening the phenotypes in early-onset seizure and severe developmental delay disorders through gene panel analysis.

PubMed ID: 26993267

DOI: 10.1136/jmedgenet-2015-103263

PubMed ID: 27864847

Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.

PubMed ID: 27864847

DOI: 10.1002/humu.23149

Sequence Information:

  • Length: 1230
  • Mass: 138343
  • Checksum: 482D70015434493E
  • Sequence:
  • MARAKLPRSP SEGKAGPGGA PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG QRLPVEDFSL 
    DSSLSQVQVE FYVNENTFKE RLKLFFIKNQ RSSLRIRLFN FSLKLLTCLL YIVRVLLDDP 
    ALGIGCWGCP KQNYSFNDSS SEINWAPILW VERKMTLWAI QVIVAIISFL ETMLLIYLSY 
    KGNIWEQIFR VSFVLEMINT LPFIITIFWP PLRNLFIPVF LNCWLAKHAL ENMINDFHRA 
    ILRTQSAMFN QVLILFCTLL CLVFTGTCGI QHLERAGENL SLLTSFYFCI VTFSTVGYGD 
    VTPKIWPSQL LVVIMICVAL VVLPLQFEEL VYLWMERQKS GGNYSRHRAQ TEKHVVLCVS 
    SLKIDLLMDF LNEFYAHPRL QDYYVVILCP TEMDVQVRRV LQIPLWSQRV IYLQGSALKD 
    QDLMRAKMDN GEACFILSSR NEVDRTAADH QTILRAWAVK DFAPNCPLYV QILKPENKFH 
    VKFADHVVCE EECKYAMLAL NCICPATSTL ITLLVHTSRG QEGQESPEQW QRMYGRCSGN 
    EVYHIRMGDS KFFREYEGKS FTYAAFHAHK KYGVCLIGLK REDNKSILLN PGPRHILAAS 
    DTCFYINITK EENSAFIFKQ EEKRKKRAFS GQGLHEGPAR LPVHSIIASM GTVAMDLQGT 
    EHRPTQSGGG GGGSKLALPT ENGSGSRRPS IAPVLELADS SALLPCDLLS DQSEDEVTPS 
    DDEGLSVVEY VKGYPPNSPY IGSSPTLCHL LPVKAPFCCL RLDKGCKHNS YEDAKAYGFK 
    NKLIIVSAET AGNGLYNFIV PLRAYYRSRK ELNPIVLLLD NKPDHHFLEA ICCFPMVYYM 
    EGSVDNLDSL LQCGIIYADN LVVVDKESTM SAEEDYMADA KTIVNVQTMF RLFPSLSITT 
    ELTHPSNMRF MQFRAKDSYS LALSKLEKRE RENGSNLAFM FRLPFAAGRV FSISMLDTLL 
    YQSFVKDYMI TITRLLLGLD TTPGSGYLCA MKITEGDLWI RTYGRLFQKL CSSSAEIPIG 
    IYRTESHVFS TSESQISVNV EDCEDTREVK GPWGSRAGTG GSSQGRHTGG GDPAEHPLLR 
    RKSLQWARRL SRKAPKQAGR AAAAEWISQQ RLSLYRRSER QELSELVKNR MKHLGLPTTG 
    YEDVANLTAS DVMNRVNLGY LQDEMNDHQN TLSYVLINPP PDTRLEPSDI VYLIRSDPLA 
    HVASSSQSRK SSCSHKLSSC NPETRDETQL

Genular Protein ID: 2969635773

Symbol: A0A6Q8PGM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 1175
  • Mass: 133179
  • Checksum: 555E5E75D0719C39
  • Sequence:
  • MVQVEFYVNE NTFKERLKLF FIKNQRSSLR IRLFNFSLKL LTCLLYIVRV LLDDPALGIG 
    CWGCPKQNYS FNDSSSEINW APILWVERKM TLWAIQVIVA IISFLETMLL IYLSYKGNIW 
    EQIFRVSFVL EMINTLPFII TIFWPPLRNL FIPVFLNCWL AKHALENMIN DFHRAILRTQ 
    SAMFNQVLIL FCTLLCLVFT GGCRTCGIQH LERAGENLSL LTSFYFCIVT FSTVGYGDVT 
    PKIWPSQLLV VIMICVALVV LPLQFEELVY LWMERQKSGG NYSRHRAQTE KHVVLCVSSL 
    KIDLLMDFLN EFYAHPRLQD YYVVILCPTE MDVQVRRVLQ IPLWSQRVIY LQGSALKDQD 
    LMRAKMDNGE ACFILSSRNE VDRTAADHQT ILRAWAVKDF APNCPLYVQI LKPENKFHVK 
    FADHVVCEEE CKYAMLALNC ICPATSTLIT LLVHTSRGQE GQESPEQWQR MYGRCSGNEV 
    YHIRMGDSKF FREYEGKSFT YAAFHAHKKY GVCLIGLKRE DNKSILLNPG PRHILAASDT 
    CFYINITKEE NSAFIFKQEE KRKKRAFSGQ GLHEGPARLP VHSIIASMGT VAMDLQGTEH 
    RPTQSGGGGG GSKLALPTEN GSGSRRPSIA PVLELADSSA LLPCDLLSDQ SEDEVTPSDD 
    EGLSVVEYVK GYPPNSPYIG SSPTLCHLLP VKAPFCCLRL DKGCKHNSYE DAKAYGFKNK 
    LIIVSAETAG NGLYNFIVPL RAYYRSRKEL NPIVLLLDNK PDHHFLEAIC CFPMVYYMEG 
    SVDNLDSLLQ CGIIYADNLV VVDKESTMSA EEDYMADAKT IVNVQTMFRL FPSLSITTEL 
    THPSNMRFMQ FRAKDSYSLA LSKLEKRERE NGSNLAFMFR LPFAAGRVFS ISMLDTLLYQ 
    SFVKDYMITI TRLLLGLDTT PGSGYLCAMK ITEGDLWIRT YGRLFQKLCS SSAEIPIGIY 
    RTESHVFSTS EPHDLRAQSQ ISVNVEDCED TREVKGPWGS RAGTGGSSQG RHTGGGDPAE 
    HPLLRRKSLQ WARRLSRKAP KQAGRAAAAE WISQQRLSLY RRSERQELSE LVKNRMKHLG 
    LPTTGYEDVA NLTASDVMNR VNLGYLQDEM NDHQNTLSYV LINPPPDTRL EPSDIVYLIR 
    SDPLAHVASS SQSRKSSCSH KLSSCNPETR DETQL

Genular Protein ID: 2001134943

Symbol: A0A0R4J2E0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 1223
  • Mass: 137642
  • Checksum: 5EB42423861D9298
  • Sequence:
  • MARAKLPRSP SEGKAGPGGA PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG QRVQVEFYVN 
    ENTFKERLKL FFIKNQRSSL RIRLFNFSLK LLTCLLYIVR VLLDDPALGI GCWGCPKQNY 
    SFNDSSSEIN WAPILWVERK MTLWAIQVIV AIISFLETML LIYLSYKGNI WEQIFRVSFV 
    LEMINTLPFI ITIFWPPLRN LFIPVFLNCW LAKHALENMI NDFHRAILRT QSAMFNQVLI 
    LFCTLLCLVF TGTCGIQHLE RAGENLSLLT SFYFCIVTFS TVGYGDVTPK IWPSQLLVVI 
    MICVALVVLP LQFEELVYLW MERQKSGGNY SRHRAQTEKH VVLCVSSLKI DLLMDFLNEF 
    YAHPRLQDYY VVILCPTEMD VQVRRVLQIP LWSQRVIYLQ GSALKDQDLM RAKMDNGEAC 
    FILSSRNEVD RTAADHQTIL RAWAVKDFAP NCPLYVQILK PENKFHVKFA DHVVCEEECK 
    YAMLALNCIC PATSTLITLL VHTSRGQEGQ ESPEQWQRMY GRCSGNEVYH IRMGDSKFFR 
    EYEGKSFTYA AFHAHKKYGV CLIGLKREDN KSILLNPGPR HILAASDTCF YINITKEENS 
    AFIFKQEEKR KKRAFSGQGL HEGPARLPVH SIIASMGTVA MDLQGTEHRP TQSGGGGGGS 
    KLALPTENGS GSRRPSIAPV LELADSSALL PCDLLSDQSE DEVTPSDDEG LSVVEYVKGY 
    PPNSPYIGSS PTLCHLLPVK APFCCLRLDK GCKHNSYEDA KAYGFKNKLI IVSAETAGNG 
    LYNFIVPLRA YYRSRKELNP IVLLLDNKPD HHFLEAICCF PMVYYMEGSV DNLDSLLQCG 
    IIYADNLVVV DKESTMSAEE DYMADAKTIV NVQTMFRLFP SLSITTELTH PSNMRFMQFR 
    AKDSYSLALS KLEKRERENG SNLAFMFRLP FAAGRVFSIS MLDTLLYQSF VKDYMITITR 
    LLLGLDTTPG SGYLCAMKIT EGDLWIRTYG RLFQKLCSSS AEIPIGIYRT ESHVFSTSEP 
    HDLRAQSQIS VNVEDCEDTR EVKGPWGSRA GTGGSSQGRH TGGGDPAEHP LLRRKSLQWA 
    RRLSRKAPKQ AGRAAAAEWI SQQRLSLYRR SERQELSELV KNRMKHLGLP TTGYEDVANL 
    TASDVMNRVN LGYLQDEMND HQNTLSYVLI NPPPDTRLEP SDIVYLIRSD PLAHVASSSQ 
    SRKSSCSHKL SSCNPETRDE TQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.