WDR48 | ENSG00000114742 | NCBI 57599

Details for: WDR48

Gene ID: 57599

Symbol: WDR48

Ensembl ID: ENSG00000114742

Description: WD repeat domain 48

Associated with

Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage bypass
(R-HSA-73893)
Dna repair
(R-HSA-73894)
Fanconi anemia pathway
(R-HSA-6783310)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Signaling by cytosolic pdgfra and pdgfrb fusion proteins
(R-HSA-9673766)
Signaling by pdgfr in disease
(R-HSA-9671555)
Ub-specific processing proteases
(R-HSA-5689880)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Deubiquitinase activator activity
(GO:0035800)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Double-strand break repair via homologous recombination
(GO:0000724)
Double-stranded dna binding
(GO:0003690)
Embryonic organ development
(GO:0048568)
Homeostasis of number of cells
(GO:0048872)
Intracellular membrane-bounded organelle
(GO:0043231)
Late endosome
(GO:0005770)
Lysosome
(GO:0005764)
Multicellular organism growth
(GO:0035264)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein binding
(GO:0005515)
Regulation of protein monoubiquitination
(GO:1902525)
Seminiferous tubule development
(GO:0072520)
Single-stranded dna binding
(GO:0003697)
Single fertilization
(GO:0007338)
Skeletal system morphogenesis
(GO:0048705)
Skin development
(GO:0043588)
Spermatogenesis
(GO:0007283)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

WD repeat endosomal protein

Genular Protein ID: 383374780

Symbol: WDR48_HUMAN

Name: WD repeat endosomal protein

UniProtKB Accession Codes:

Q8TAF3 B4DM86 B4DQI2 B4DY84 Q63HJ2 Q658Y1 Q8N3Z1 Q9NSK8 Q9P279

Database IDs:

Citations:

PubMed ID: 12196293

Title: Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression.

PubMed ID: 12196293

DOI: 10.1016/s1074-7613(02)00368-0

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12885920

Title: Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts.

PubMed ID: 12885920

DOI: 10.1128/jvi.77.16.9041-9051.2003

PubMed ID: 18082604

Title: A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.

PubMed ID: 18082604

DOI: 10.1016/j.molcel.2007.09.031

PubMed ID: 18032488

Title: Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes.

PubMed ID: 18032488

DOI: 10.1128/jvi.01405-07

PubMed ID: 19075014

Title: UAF1 is a subunit of multiple deubiquitinating enzyme complexes.

PubMed ID: 19075014

DOI: 10.1074/jbc.m808430200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20147293

Title: Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

PubMed ID: 20147293

DOI: 10.1074/jbc.m109.092544

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24145035

Title: WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1).

PubMed ID: 24145035

DOI: 10.1074/jbc.m113.503383

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25855980

Title: The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.

PubMed ID: 25855980

DOI: 10.1371/journal.ppat.1004822

PubMed ID: 27463890

Title: The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.

PubMed ID: 27463890

DOI: 10.1080/15384101.2016.1209613

PubMed ID: 27239033

Title: Promotion of RAD51-mediated homologous DNA pairing by the RAD51AP1-UAF1 complex.

PubMed ID: 27239033

DOI: 10.1016/j.celrep.2016.05.007

PubMed ID: 31844045

Title: ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress.

PubMed ID: 31844045

DOI: 10.1038/s41467-019-13667-4

PubMed ID: 31253762

Title: DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response.

PubMed ID: 31253762

DOI: 10.1038/s41467-019-10408-5

PubMed ID: 32350107

Title: The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair.

PubMed ID: 32350107

DOI: 10.1074/jbc.ra120.013714

PubMed ID: 33844468

Title: The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.

PubMed ID: 33844468

DOI: 10.1111/febs.15875

PubMed ID: 37289831

Title: Human Cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection.

PubMed ID: 37289831

DOI: 10.1371/journal.ppat.1011185

PubMed ID: 26388029

Title: Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46.

PubMed ID: 26388029

DOI: 10.1016/j.str.2015.08.010

PubMed ID: 27650958

Title: A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.

PubMed ID: 27650958

DOI: 10.1016/j.jsb.2016.09.011

PubMed ID: 27373336

Title: Allosteric activation of ubiquitin-specific proteases by beta-propeller proteins UAF1 and WDR20.

PubMed ID: 27373336

DOI: 10.1016/j.molcel.2016.05.031

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

Sequence Information:

Length: 677
Mass: 76210
Checksum: 20FDA620E02696E0
Sequence:

MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN 
QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV 
KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQLG 
TIIVSGSTEK VLRVWDPRTC AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG 
QQRCIATYRV HDEGVWALQV NDAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM 
ELDRSADPPP AIWVATTKST VNKWTLKGIH NFRASGDYDN DCTNPITPLC TQPDQVIKGG 
ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK VDFEDEIKKR FKMVYVPNWF 
SVDLKTGMLT ITLDESDCFA AWVSAKDAGF SSPDGSDPKL NLGGLLLQAL LEYWPRTHVN 
PMDEEENEVN HVNGEQENRV QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM 
LLNETVPQWV IDITVDKNMP KFNKIPFYLQ PHASSGAKTL KKDRLSASDM LQVRKVMEHV 
YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP NMDLRTVKHF 
IWKSGGDLTL HYRQKST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WDR48

Associated with

Other Information

Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression. PubMed ID: 12196293

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts. PubMed ID: 12885920

A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. PubMed ID: 18082604

Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes. PubMed ID: 18032488

UAF1 is a subunit of multiple deubiquitinating enzyme complexes. PubMed ID: 19075014

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. PubMed ID: 20147293

Initial characterization of the human central proteome. PubMed ID: 21269460

WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). PubMed ID: 24145035

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. PubMed ID: 25855980

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair. PubMed ID: 27463890

Promotion of RAD51-mediated homologous DNA pairing by the RAD51AP1-UAF1 complex. PubMed ID: 27239033

ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress. PubMed ID: 31844045

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response. PubMed ID: 31253762

The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair. PubMed ID: 32350107

The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase. PubMed ID: 33844468

Human Cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection. PubMed ID: 37289831

Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46. PubMed ID: 26388029

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. PubMed ID: 27650958

Allosteric activation of ubiquitin-specific proteases by beta-propeller proteins UAF1 and WDR20. PubMed ID: 27373336

Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. PubMed ID: 24482476