Details for: ADGRB2

Gene ID: 576

Symbol: ADGRB2

Ensembl ID: ENSG00000121753

Description: adhesion G protein-coupled receptor B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.1471
    Cell Significance Index: -13.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.4582
    Cell Significance Index: -14.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.6791
    Cell Significance Index: -13.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5562
    Cell Significance Index: 44.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4330
    Cell Significance Index: 287.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3173
    Cell Significance Index: 42.1900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.1357
    Cell Significance Index: 15.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9076
    Cell Significance Index: 61.0300
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.7679
    Cell Significance Index: 5.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7495
    Cell Significance Index: 74.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6595
    Cell Significance Index: 29.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6471
    Cell Significance Index: 584.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6172
    Cell Significance Index: 23.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5798
    Cell Significance Index: 14.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5209
    Cell Significance Index: 186.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3840
    Cell Significance Index: 62.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2728
    Cell Significance Index: 51.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2367
    Cell Significance Index: 14.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2179
    Cell Significance Index: 4.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2178
    Cell Significance Index: 150.6200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.2076
    Cell Significance Index: 2.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2034
    Cell Significance Index: 5.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1671
    Cell Significance Index: 10.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1565
    Cell Significance Index: 10.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1278
    Cell Significance Index: 1.5900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1062
    Cell Significance Index: 1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0418
    Cell Significance Index: 1.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0304
    Cell Significance Index: 1.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0248
    Cell Significance Index: 0.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0085
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0030
    Cell Significance Index: 0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -1.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0130
    Cell Significance Index: -0.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0133
    Cell Significance Index: -0.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0171
    Cell Significance Index: -7.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0191
    Cell Significance Index: -14.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0197
    Cell Significance Index: -14.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0205
    Cell Significance Index: -15.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0212
    Cell Significance Index: -13.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0243
    Cell Significance Index: -11.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0266
    Cell Significance Index: -15.0200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0314
    Cell Significance Index: -0.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0319
    Cell Significance Index: -0.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0404
    Cell Significance Index: -1.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0408
    Cell Significance Index: -11.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0442
    Cell Significance Index: -7.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0482
    Cell Significance Index: -9.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0505
    Cell Significance Index: -1.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0508
    Cell Significance Index: -7.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0549
    Cell Significance Index: -1.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0573
    Cell Significance Index: -0.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0595
    Cell Significance Index: -8.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0605
    Cell Significance Index: -3.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0661
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0693
    Cell Significance Index: -14.5900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0756
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0780
    Cell Significance Index: -9.5900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0895
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0960
    Cell Significance Index: -16.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1029
    Cell Significance Index: -3.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1048
    Cell Significance Index: -13.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1074
    Cell Significance Index: -13.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1078
    Cell Significance Index: -8.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1130
    Cell Significance Index: -11.5400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1131
    Cell Significance Index: -0.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1211
    Cell Significance Index: -14.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1214
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1249
    Cell Significance Index: -14.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1301
    Cell Significance Index: -7.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1304
    Cell Significance Index: -13.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1335
    Cell Significance Index: -7.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1457
    Cell Significance Index: -2.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1531
    Cell Significance Index: -3.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1634
    Cell Significance Index: -12.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1685
    Cell Significance Index: -2.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1785
    Cell Significance Index: -2.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1824
    Cell Significance Index: -14.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1881
    Cell Significance Index: -11.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1972
    Cell Significance Index: -13.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2066
    Cell Significance Index: -5.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2201
    Cell Significance Index: -7.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2364
    Cell Significance Index: -15.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2393
    Cell Significance Index: -5.1700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2403
    Cell Significance Index: -3.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2426
    Cell Significance Index: -12.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2432
    Cell Significance Index: -6.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2484
    Cell Significance Index: -12.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2516
    Cell Significance Index: -4.3500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2648
    Cell Significance Index: -2.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2785
    Cell Significance Index: -13.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2798
    Cell Significance Index: -6.9800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3124
    Cell Significance Index: -3.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3163
    Cell Significance Index: -6.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3354
    Cell Significance Index: -8.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3417
    Cell Significance Index: -15.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3581
    Cell Significance Index: -8.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADGRB2 is a GPCR that belongs to the class B family, characterized by its specific ligand-binding domain and seven transmembrane helices. This receptor exhibits a high degree of specificity for its ligands, which include the angiopoietin-1 (Ang-1) and angiopoietin-4 (Ang-4) proteins. The receptor's structure and ligand-binding properties enable it to interact with various signaling pathways, including the adenylate cyclase-activating GPCR signaling pathway and the calcineurin-NFAT signaling cascade. ADGRB2 has been found to be expressed in a range of cell types, including kidney proximal convoluted tubule epithelial cells, corticothalamic-projecting glutamatergic cortical neurons, and cardiac endothelial cells. **Pathways and Functions:** ADGRB2 plays a crucial role in regulating angiogenesis, a process essential for tissue development and repair. The receptor interacts with its ligands to activate the adenylate cyclase-activating GPCR signaling pathway, leading to the production of cyclic AMP (cAMP) and subsequent activation of downstream signaling molecules. This pathway is involved in the regulation of endothelial cell migration, proliferation, and survival. ADGRB2 also modulates the calcineurin-NFAT signaling cascade, which is essential for the development and function of the nervous system. This receptor has been shown to interact with NFAT proteins, influencing their activity and transcriptional regulation. In addition to its role in angiogenesis and neurological development, ADGRB2 has been implicated in immune regulation. The receptor has been found to interact with various immune cells, including granulocyte monocyte progenitor cells, and modulate their function. ADGRB2 has also been shown to regulate the expression of genes involved in immune responses, including those related to inflammation and immune cell differentiation. **Clinical Significance:** ADGRB2 has been implicated in various immune-related disorders and neurological diseases, including: 1. **Autoimmune diseases:** ADGRB2 has been found to be involved in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders:** ADGRB2 has been implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). The receptor's role in modulating the calcineurin-NFAT signaling cascade makes it a potential target for therapeutic intervention. 3. **Cancer:** ADGRB2 has been found to be overexpressed in certain types of cancer, including glioblastoma and breast cancer. The receptor's role in angiogenesis and immune regulation makes it a potential target for cancer therapy. 4. **Vascular diseases:** ADGRB2 has been implicated in the regulation of angiogenesis, and its dysregulation has been linked to vascular diseases such as atherosclerosis and hypertension. In conclusion, ADGRB2 is a complex receptor with multifaceted roles in immune regulation, neurological function, and angiogenesis. Further research is needed to fully elucidate the receptor's mechanisms of action and its clinical significance in various diseases. However, the available evidence suggests that ADGRB2 holds significant promise as a therapeutic target for the treatment of immune-related disorders and neurological diseases.

Genular Protein ID: 2009775877

Symbol: AGRB2_HUMAN

Name: Brain-specific angiogenesis inhibitor 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9533023

Title: Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).

PubMed ID: 9533023

DOI: 10.1159/000134693

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20367554

Title: Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing.

PubMed ID: 20367554

DOI: 10.3109/10799891003671139

PubMed ID: 21787750

Title: Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.

PubMed ID: 21787750

DOI: 10.1016/j.bbrc.2011.07.029

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 25713288

Title: International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors.

PubMed ID: 25713288

DOI: 10.1124/pr.114.009647

PubMed ID: 28891236

Title: A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity.

PubMed ID: 28891236

DOI: 10.1002/humu.23336

Sequence Information:

  • Length: 1585
  • Mass: 172656
  • Checksum: 56D253AE0AB1552D
  • Sequence:
  • MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT 
    IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ 
    AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF 
    RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG 
    PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 
    GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT 
    CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG 
    QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP 
    WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM 
    LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 
    EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD 
    DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD 
    NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA 
    GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR 
    VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 
    AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF 
    IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ 
    SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF 
    VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP 
    LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA 
    VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN 
    TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE 
    ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG 
    TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE 
    RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS 
    QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR 
    ERLTLHRAAA WEPTEPPDGD FQTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.