Details for: ADGRB2

Gene ID: 576

Symbol: ADGRB2

Ensembl ID: ENSG00000121753

Description: adhesion G protein-coupled receptor B2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.49
    Marker Score: 5156
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.4
    Marker Score: 13265
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.39
    Marker Score: 2327
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.3
    Marker Score: 11174
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1978
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.27
    Marker Score: 78007
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18786
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7656
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2168
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.05
    Marker Score: 3006.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1
    Marker Score: 3705.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1
    Marker Score: 3869
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.99
    Marker Score: 7615
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5314
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.84
    Marker Score: 673
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.79
    Marker Score: 1223
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1288
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3259
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.76
    Marker Score: 7840
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.75
    Marker Score: 4469.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.71
    Marker Score: 1675
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1390
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.67
    Marker Score: 2740
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.67
    Marker Score: 6257
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.67
    Marker Score: 24537.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.66
    Marker Score: 13091
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 394
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.65
    Marker Score: 3030
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 310
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.6
    Marker Score: 316
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.6
    Marker Score: 12796
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 383
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.52
    Marker Score: 7771
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 320
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 152.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 193
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.43
    Marker Score: 482
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 15836
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 178
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.39
    Marker Score: 1636
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.37
    Marker Score: 511
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.37
    Marker Score: 123
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.35
    Marker Score: 435
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.34
    Marker Score: 809
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.34
    Marker Score: 420.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 86
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.33
    Marker Score: 283
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 309
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3
    Marker Score: 525
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.29
    Marker Score: 105
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.29
    Marker Score: 776
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.28
    Marker Score: 508
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.27
    Marker Score: 552
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 82
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.22
    Marker Score: 422
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.22
    Marker Score: 78
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.21
    Marker Score: 242
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.21
    Marker Score: 356
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2
    Marker Score: 2656
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.2
    Marker Score: 154
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.2
    Marker Score: 386
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.2
    Marker Score: 79
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.18
    Marker Score: 430.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.18
    Marker Score: 68
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.18
    Marker Score: 130.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.17
    Marker Score: 66
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.17
    Marker Score: 242
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.17
    Marker Score: 56
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.16
    Marker Score: 630
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.16
    Marker Score: 1049
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.16
    Marker Score: 1393
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.16
    Marker Score: 82
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.15
    Marker Score: 181

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Other Information

**Key characteristics:** - ADGRB2 is a type of adhesion G protein-coupled receptor (GPCR). - It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. - It is a key regulator of angiogenesis. **Pathways and functions:** **1. Adenylate cyclase-activating g protein-coupled receptor signaling pathway:** - ADGRB2 is a key regulator of the adenylate cyclase-activating G protein-coupled receptor signaling pathway. - Activation of ADGRB2 by its ligand, vascular endothelial growth factor (VEGF), leads to the activation of the pathway. - This pathway promotes the migration and proliferation of endothelial cells, which is essential for the formation of new blood vessels. **2. Calcineurin-nfat signaling cascade:** - ADGRB2 is also a key regulator of the calcineurin-nfat signaling cascade. - Activation of ADGRB2 by its ligand, VEGF, leads to the activation of the calcineurin-nfat pathway. - This pathway promotes the production of pro-inflammatory cytokines and chemokines, which can contribute to the development of inflammation and tissue damage. **3. Cell surface receptor signaling pathway:** - ADGRB2 is also expressed on the surface of immune cells, such as macrophages and dendritic cells. - Activation of ADGRB2 by its ligand, fractalkine, promotes the migration and activation of these cells. - This pathway is involved in the regulation of inflammation and immune responses. **4. Extracellular region:** - The extracellular region of ADGRB2 is responsible for its interaction with its ligands. - It contains a single extracellular domain that is involved in binding to VEGF and other ligands. **5. G protein-coupled receptor activity:** - ADGRB2 is a GPCR, which means that it is a cell surface protein that binds to G proteins. - When ADGRB2 binds to its ligand, it activates the G protein, which then recruits other proteins to the cell surface. - This activation leads to the downstream signaling pathways that promote angiogenesis. **Clinical significance:** - Mutations in the ADGRB2 gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. - Targeting ADGRB2 has been explored as a therapeutic strategy for these diseases. - ADGRB2 is a promising target for the development of new drugs that can inhibit angiogenesis and improve disease outcomes.

Genular Protein ID: 2009775877

Symbol: AGRB2_HUMAN

Name: Brain-specific angiogenesis inhibitor 2

UniProtKB Accession Codes:

O60241 B9EGK9 Q5T6K0 Q8NGW8 Q96GZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 7 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9533023

Title: Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).

PubMed ID: 9533023

DOI: 10.1159/000134693

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20367554

Title: Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing.

PubMed ID: 20367554

DOI: 10.3109/10799891003671139

PubMed ID: 21787750

Title: Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.

PubMed ID: 21787750

DOI: 10.1016/j.bbrc.2011.07.029

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 25713288

Title: International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors.

PubMed ID: 25713288

DOI: 10.1124/pr.114.009647

PubMed ID: 28891236

Title: A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity.

PubMed ID: 28891236

DOI: 10.1002/humu.23336

Sequence Information:

  • Length: 1585
  • Mass: 172656
  • Checksum: 56D253AE0AB1552D
  • Sequence:
    • MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT 
IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ 
AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF 
RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG 
PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT 
CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG 
QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP 
WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM 
LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD 
DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD 
NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA 
GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR 
VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF 
IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ 
SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF 
VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP 
LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA 
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN 
TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE 
ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG 
TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE 
RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS 
QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR 
ERLTLHRAAA WEPTEPPDGD FQTEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.