VPS18 | ENSG00000104142 | NCBI 57617

Details for: VPS18

Gene ID: 57617

Symbol: VPS18

Ensembl ID: ENSG00000104142

Description: VPS18 core subunit of CORVET and HOPS complexes

Associated with

Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates autophagy
(R-HSA-9754560)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Actin binding
(GO:0003779)
Actin filament
(GO:0005884)
Ap-3 adaptor complex
(GO:0030123)
Autophagosome
(GO:0005776)
Autophagy
(GO:0006914)
Clathrin-coated vesicle
(GO:0030136)
Corvet complex
(GO:0033263)
Early endosome
(GO:0005769)
Endosomal vesicle fusion
(GO:0034058)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome organization
(GO:0007032)
Endosome to lysosome transport
(GO:0008333)
Glutamatergic synapse
(GO:0098978)
Hops complex
(GO:0030897)
Intracellular protein transport
(GO:0006886)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Lysosome organization
(GO:0007040)
Metal ion binding
(GO:0046872)
Negative regulation of intracellular estrogen receptor signaling pathway
(GO:0033147)
Organelle fusion
(GO:0048284)
Presynapse
(GO:0098793)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of snare complex assembly
(GO:0035542)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Symbiont entry into host cell
(GO:0046718)
Syntaxin binding
(GO:0019905)
Ubiquitin protein ligase activity
(GO:0061630)
Vesicle docking involved in exocytosis
(GO:0006904)

Other Information

Proteins

Vacuolar protein sorting-associated protein 18 homolog

Genular Protein ID: 1738535793

Symbol: VPS18_HUMAN

Name: Vacuolar protein sorting-associated protein 18 homolog

UniProtKB Accession Codes:

Q9P253 Q8TCG0 Q96DI3 Q9H268

Database IDs:

Citations:

PubMed ID: 11250079

Title: Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33.

PubMed ID: 11250079

DOI: 10.1016/s0378-1119(01)00333-x

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11382755

Title: Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.

PubMed ID: 11382755

DOI: 10.1074/jbc.m101778200

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18552835

Title: Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

PubMed ID: 18552835

DOI: 10.1038/ncb1740

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20434987

Title: Identification of the switch in early-to-late endosome transition.

PubMed ID: 20434987

DOI: 10.1016/j.cell.2010.03.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21802320

Title: Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

PubMed ID: 21802320

DOI: 10.1016/j.immuni.2011.06.009

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23434281

Title: Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

PubMed ID: 23434281

DOI: 10.1016/j.cub.2013.01.064

PubMed ID: 23351085

Title: Tethering complexes in the endocytic pathway: CORVET and HOPS.

PubMed ID: 23351085

DOI: 10.1111/febs.12151

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23901104

Title: Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

PubMed ID: 23901104

DOI: 10.1073/pnas.1307074110

PubMed ID: 24554770

Title: The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.

PubMed ID: 24554770

DOI: 10.1091/mbc.e13-08-0447

PubMed ID: 25783203

Title: Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

PubMed ID: 25783203

DOI: 10.1111/tra.12283

PubMed ID: 28325809

Title: The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

PubMed ID: 28325809

DOI: 10.1083/jcb.201607085

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 973
Mass: 110186
Checksum: 0008E21D66E8CFEC
Sequence:

MASILDEYEN SLSRSAVLQP GCPSVGIPHS GYVNAQLEKE VPIFTKQRID FTPSERITSL 
VVSSNQLCMS LGKDTLLRID LGKANEPNHV ELGRKDDAKV HKMFLDHTGS HLLIALSSTE 
VLYVNRNGQK VRPLARWKGQ LVESVGWNKA LGTESSTGPI LVGTAQGHIF EAELSASEGG 
LFGPAPDLYF RPLYVLNEEG GPAPVCSLEA ERGPDGRSFV IATTRQRLFQ FIGRAAEGAE 
AQGFSGLFAA YTDHPPPFRE FPSNLGYSEL AFYTPKLRSA PRAFAWMMGD GVLYGALDCG 
RPDSLLSEER VWEYPEGVGP GASPPLAIVL TQFHFLLLLA DRVEAVCTLT GQVVLRDHFL 
EKFGPLKHMV KDSSTGQLWA YTERAVFRYH VQREARDVWR TYLDMNRFDL AKEYCRERPD 
CLDTVLAREA DFCFRQRRYL ESARCYALTQ SYFEEIALKF LEARQEEALA EFLQRKLASL 
KPAERTQATL LTTWLTELYL SRLGALQGDP EALTLYRETK ECFRTFLSSP RHKEWLFASR 
ASIHELLASH GDTEHMVYFA VIMQDYERVV AYHCQHEAYE EALAVLARHR DPQLFYKFSP 
ILIRHIPRQL VDAWIEMGSR LDARQLIPAL VNYSQGGEVQ QVSQAIRYME FCVNVLGETE 
QAIHNYLLSL YARGRPDSLL AYLEQAGASP HRVHYDLKYA LRLCAEHGHH RACVHVYKVL 
ELYEEAVDLA LQVDVDLAKQ CADLPEEDEE LRKKLWLKIA RHVVQEEEDV QTAMACLASC 
PLLKIEDVLP FFPDFVTIDH FKEAICSSLK AYNHHIQELQ REMEEATASA QRIRRDLQEL 
RGRYGTVEPQ DKCATCDFPL LNRPFYLFLC GHMFHADCLL QAVRPGLPAY KQARLEELQR 
KLGAAPPPAK GSARAKEAEG GAATAGPSRE QLKADLDELV AAECVYCGEL MIRSIDRPFI 
DPQRYEEEQL SWL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: VPS18

Associated with

Other Information

Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. PubMed ID: 11250079

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. PubMed ID: 11382755

Integral and associated lysosomal membrane proteins. PubMed ID: 17897319

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. PubMed ID: 18552835

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Identification of the switch in early-to-late endosome transition. PubMed ID: 20434987

Initial characterization of the human central proteome. PubMed ID: 21269460

Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. PubMed ID: 21802320

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. PubMed ID: 23434281

Tethering complexes in the endocytic pathway: CORVET and HOPS. PubMed ID: 23351085

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. PubMed ID: 23901104

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. PubMed ID: 24554770

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes. PubMed ID: 25783203

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. PubMed ID: 28325809

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974