DHX37 | ENSG00000150990 | NCBI 57647

Details for: DHX37

Gene ID: 57647

Symbol: DHX37

Ensembl ID: ENSG00000150990

Description: DEAH-box helicase 37

Associated with

Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism of rna
(R-HSA-8953854)
Rrna modification in the nucleus and cytosol
(R-HSA-6790901)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Brain development
(GO:0007420)
Cytoplasm
(GO:0005737)
Helicase activity
(GO:0004386)
Intracellular anatomical structure
(GO:0005622)
Maturation of ssu-rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000462)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of male gonad development
(GO:2000020)
Protein binding
(GO:0005515)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome assembly
(GO:0042255)
Ribosome biogenesis
(GO:0042254)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Small-subunit processome
(GO:0032040)
U3 snorna binding
(GO:0034511)

Other Information

Proteins

Probable ATP-dependent RNA helicase DHX37

Genular Protein ID: 3942848350

Symbol: DHX37_HUMAN

Name: Probable ATP-dependent RNA helicase DHX37

UniProtKB Accession Codes:

Q8IY37 Q9BUI7 Q9P211

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26539891

Title: Genes that affect brain structure and function identified by rare variant analyses of mendelian neurologic disease.

PubMed ID: 26539891

DOI: 10.1016/j.neuron.2015.09.048

PubMed ID: 31287541

Title: Genetic evidence of the association of DEAH-box helicase 37 defects with 46,XY gonadal dysgenesis spectrum.

PubMed ID: 31287541

DOI: 10.1210/jc.2019-00984

PubMed ID: 30582406

Title: The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles.

PubMed ID: 30582406

DOI: 10.1080/15476286.2018.1556149

PubMed ID: 31256877

Title: Paralog studies augment gene discovery: DDX and DHX genes.

PubMed ID: 31256877

DOI: 10.1016/j.ajhg.2019.06.001

PubMed ID: 31337883

Title: Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome.

PubMed ID: 31337883

DOI: 10.1038/s41436-019-0606-y

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 1157
Mass: 129545
Checksum: 49332175221B30C5
Sequence:

MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV LPGKKKKKTK 
APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL SEVQASEAEM RLFYTTSKLG 
TGNRMYHTKE KADEVVAPGQ EKISSLSGAH RKRRRWPSAE EEEEEEEESE SELEEESELD 
EDPAAEPAEA GVGTTVAPLP PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN 
RSPEMQEERL KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI 
IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD GVLLKEIQKD 
FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL PLKLLIMSAT LRVEDFTQNP 
RLFAKPPPVI KVESRQFPVT VHFNKRTPLE DYSGECFRKV CKIHRMLPAG GILVFLTGQA 
EVHALCRRLR KAFPPSRARP QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY 
SVLPAGEGDE DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE 
KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT GVSSFRVTWV 
SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI TRRPVEDLIL QMKALNVEKV 
INFPFPTPPS VEALLAAEEL LIALGALQPP QKAERVKQLQ ENRLSCPITA LGRTMATFPV 
APRYAKMLAL SRQHGCLPYA ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK 
RTWAGQGASL KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN 
AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK WRNAYKTPLL 
DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE VQWIPALLPS YCQFDKPLEE 
PAPTYCPERG RVLCHRASVF YRVGWPLPAI EVDFPEGIDR YKHFARFLLE GQVFRKLASY 
RSCLLSSPGT MLKTWARLQP RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP 
QAMHPDIEKA WPPTTVH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DHX37

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

Initial characterization of the human central proteome. PubMed ID: 21269460

Genes that affect brain structure and function identified by rare variant analyses of mendelian neurologic disease. PubMed ID: 26539891

Genetic evidence of the association of DEAH-box helicase 37 defects with 46,XY gonadal dysgenesis spectrum. PubMed ID: 31287541

The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles. PubMed ID: 30582406

Paralog studies augment gene discovery: DDX and DHX genes. PubMed ID: 31256877

Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome. PubMed ID: 31337883

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797