Details for: CIP2A

Gene ID: 57650

Symbol: CIP2A

Ensembl ID: ENSG00000163507

Description: cellular inhibitor of PP2A

Associated with

Other Information

Genular Protein ID: 146477072

Symbol: CIP2A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TCG1 A1L4J7 B9EGC3 Q6P4G6 Q8WVP8 Q96PI2 Q9H9C6 Q9P204

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12118381

Title: Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer.

PubMed ID: 12118381

DOI: 10.1038/sj.onc.1205625

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15538718

Title: Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens.

PubMed ID: 15538718

DOI: 10.1002/pros.20181

PubMed ID: 17632056

Title: CIP2A inhibits PP2A in human malignancies.

PubMed ID: 17632056

DOI: 10.1016/j.cell.2007.04.044

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35121901

Title: The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer.

PubMed ID: 35121901

DOI: 10.1038/s43018-021-00266-w

PubMed ID: 35842428

Title: The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.

PubMed ID: 35842428

DOI: 10.1038/s41467-022-31865-5

PubMed ID: 37165191

Title: Mitotic clustering of pulverized chromosomes from micronuclei.

PubMed ID: 37165191

DOI: 10.1038/s41586-023-05974-0

PubMed ID: 37316668

Title: Mitotic tethering enables inheritance of shattered micronuclear chromosomes.

PubMed ID: 37316668

DOI: 10.1038/s41586-023-06216-z

PubMed ID: 28174209

Title: Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.

PubMed ID: 28174209

DOI: 10.15252/embr.201642788

Sequence Information:

  • Length: 905
  • Mass: 102185
  • Checksum: DAB9CCC03BCEA304
  • Sequence:
    • MDSTACLKSL LLTVSQYKAV KSEANATQLL RHLEVISGQK LTRLFTSNQI LTSECLSCLV 
ELLEDPNISA SLILSIIGLL SQLAVDIETR DCLQNTYNLN SVLAGVVCRS SHTDSVFLQC 
IQLLQKLTYN VKIFYSGANI DELITFLIDH IQSSEDELKM PCLGLLANLC RHNLSVQTHI 
KTLSNVKSFY RTLITLLAHS SLTVVVFALS ILSSLTLNEE VGEKLFHARN IHQTFQLIFN 
ILINGDGTLT RKYSVDLLMD LLKNPKIADY LTRYEHFSSC LHQVLGLLNG KDPDSSSKVL 
ELLLAFCSVT QLRHMLTQMM FEQSPPGSAT LGSHTKCLEP TVALLRWLSQ PLDGSENCSV 
LALELFKEIF EDVIDAANCS SADRFVTLLL PTILDQLQFT EQNLDEALTR KKCERIAKAI 
EVLLTLCGDD TLKMHIAKIL TTVKCTTLIE QQFTYGKIDL GFGTKVADSE LCKLAADVIL 
KTLDLINKLK PLVPGMEVSF YKILQDPRLI TPLAFALTSD NREQVQSGLR ILLEAAPLPD 
FPALVLGESI AANNAYRQQE TEHIPRKMPW QSSNHSFPTS IKCLTPHLKD GVPGLNIEEL 
IEKLQSGMVV KDQICDVRIS DIMDVYEMKL STLASKESRL QDLLETKALA LAQADRLIAQ 
HRCQRTQAET EARTLASMLR EVERKNEELS VLLKAQQVES ERAQSDIEHL FQHNRKLESV 
AEEHEILTKS YMELLQRNES TEKKNKDLQI TCDSLNKQIE TVKKLNESLK EQNEKSIAQL 
IEKEEQRKEV QNQLVDREHK LANLHQKTKV QEEKIKTLQK EREDKEETID ILRKELSRTE 
QIRKELSIKA SSLEVQKAQL EGRLEEKESL VKLQQEELNK HSHMIAMIHS LSGGKINPET 
VNLSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.