TNRC6C | ENSG00000078687 | NCBI 57690

Details for: TNRC6C

Gene ID: 57690

Symbol: TNRC6C

Ensembl ID: ENSG00000078687

Description: trinucleotide repeat containing adaptor 6C

Associated with

Adherens junctions interactions
(R-HSA-418990)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Competing endogenous rnas (cernas) regulate pten translation
(R-HSA-8948700)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-transcriptional silencing by small rnas
(R-HSA-426496)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 mrna translation by micrornas
(R-HSA-9759811)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 mrna translation
(R-HSA-9768778)
Regulation of pten mrna translation
(R-HSA-8943723)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation by ventx
(R-HSA-8853884)
Cytosol
(GO:0005829)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Nucleoplasm
(GO:0005654)
P-body
(GO:0000932)
Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900153)
Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
(GO:0060213)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)

Other Information

Proteins

Trinucleotide repeat-containing gene 6C protein

Genular Protein ID: 2434791846

Symbol: TNR6C_HUMAN

Name: Trinucleotide repeat-containing gene 6C protein

UniProtKB Accession Codes:

Q9HCJ0 A0A8Q3SIH5 A0A8Q3SIS0 G3XAB8 Q86UE5 Q8N3D8 Q96MU9

Database IDs:

Citations:

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19716330

Title: Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

PubMed ID: 19716330

DOI: 10.1016/j.molcel.2009.08.004

PubMed ID: 19304925

Title: Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

PubMed ID: 19304925

DOI: 10.1261/rna.1448009

PubMed ID: 19383768

Title: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

PubMed ID: 19383768

DOI: 10.1261/rna.1606309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21981923

Title: GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

PubMed ID: 21981923

DOI: 10.1016/j.molcel.2011.09.007

PubMed ID: 21984185

Title: miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.

PubMed ID: 21984185

DOI: 10.1038/nsmb.2149

PubMed ID: 21984184

Title: miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.

PubMed ID: 21984184

DOI: 10.1038/nsmb.2166

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 1936
Mass: 201830
Checksum: 3392333B087ACE5D
Sequence:

MEEKKKKKQE EKKKKEGAQK KAADQKTKVP EPTKTCSSQP QPAGTSTSTS TSTISSSNNG 
KRASASGQQP AASRYLPREV PPRFRQQEQK QLLKRGQPLP TGTLTSVSPT QGAGPAGVSP 
PPLPGAGTQH HPSKLQPDLS HSGLADHYEN SHWGQQPTYR SEANCSWDKV IIDRTDKEAW 
PSITGTETES ASECTTDTDS ASNCGSENSS MATGSAQGNF TGHTKKTNGN NGTNGALVQS 
PSNQSALGAG GANSNGSAAR VWGVATGSSS GLAHCSVSGG DGKMDTMIGD GRSQNCWGAS 
NSNAGINLNL NPNANPAAWP VLGHEGTVAT GNPSSICSPV SAIGQNMGNQ NGNPTGTLGA 
WGNLLPQEST EPQTSTSQNV SFSAQPQNLN TDGPNNTNPM NSSPNPINAM QTNGLPNWGM 
AVGMGAIIPP HLQGLPGANG SSVSQVSGGS AEGISNSVWG LSPGNPATGN SNSGFSQGNG 
DTVNSALSAK QNGSSSAVQK EGSGGNAWDS GPPAGPGILA WGRGSGNNGV GNIHSGAWGH 
PSRSTSNGVN GEWGKPPNQH SNSDINGKGS TGWESPSVTS QNPTVQPGGE HMNSWAKAAS 
SGTTASEGSS DGSGNHNEGS TGREGTGEGR RRDKGIIDQG HIQLPRNDLD PRVLSNTGWG 
QTPVKQNTAW EFEESPRSER KNDNGTEAWG CAATQASNSG GKNDGSIMNS TNTSSVSGWV 
NAPPAAVPAN TGWGDSNNKA PSGPGVWGDS ISSTAVSTAA AAKSGHAWSG AANQEDKSPT 
WGEPPKPKSQ HWGDGQRSNP AWSAGGGDWA DSSSVLGHLG DGKKNGSGWD ADSNRSGSGW 
NDTTRSGNSG WGNSTNTKAN PGTNWGETLK PGPQQNWASK PQDNNVSNWG GAASVKQTGT 
GWIGGPVPVK QKDSSEATGW EEPSPPSIRR KMEIDDGTSA WGDPSNYNNK TVNMWDRNNP 
VIQSSTTTNT TTTTTTTTSN TTHRVETPPP HQAGTQLNRS PLLGPVSSGW GEMPNVHSKT 
ENSWGEPSSP STLVDNGTAA WGKPPSSGSG WGDHPAEPPV AFGRAGAPVA ASALCKPASK 
SMQEGWGSGG DEMNLSTSQW EDEEGDVWNN AASQESTSSC SSWGNAPKKG LQKGMKTSGK 
QDEAWIMSRL IKQLTDMGFP REPAEEALKS NNMNLDQAMS ALLEKKVDVD KRGLGVTDHN 
GMAAKPLGCR PPISKESSVD RPTFLDKDGG LVEEPTPSPF LPSPSLKLPL SHSALPSQAL 
GGIASGLGMQ NLNSSRQIPS GNLGMFGNSG AAQARTMQQP PQPPVQPLNS SQPSLRAQVP 
QFLSPQVQAQ LLQFAAKNIG LNPALLTSPI NPQHMTMLNQ LYQLQLAYQR LQIQQQMLQA 
QRNVSGSMRQ QEQQVARTIT NLQQQIQQHQ RQLAQALLVK QPPPPPPPPH LSLHPSAGKS 
AMDSFPSHPQ TPGLPDLQTK EQQSSPNTFA PYPLAGLNPN MNVNSMDMTG GLSVKDPSQS 
QSRLPQWTHP NSMDNLPSAA SPLEQNPSKH GAIPGGLSIG PPGKSSIDDS YGRYDLIQNS 
ESPASPPVAV PHSWSRAKSD SDKISNGSSI NWPPEFHPGV PWKGLQNIDP ENDPDVTPGS 
VPTGPTINTT IQDVNRYLLK SGGSSPPSSQ NATLPSSSAW PLSASGYSSS FSSIASAPSV 
AGKLSDIKST WSSGPTSHTQ ASLSHELWKV PRNSTAPTRP PPGLTNPKPS STWGASPLGW 
TSSYSSGSAW STDTSGRTSS WLVLRNLTPQ IDGSTLRTLC LQHGPLITFH LNLTQGNAVV 
RYSSKEEAAK AQKSLHMCVL GNTTILAEFA GEEEVNRFLA QGQALPPTSS WQSSSASSQP 
RLSAAGSSHG LVRSDAGHWN APCLGGKGSS ELLWGGVPQY SSSLWGPPSA DDSRVIGSPT 
PLTTLLPGDL LSGESL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TNRC6C

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10997877

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. PubMed ID: 19716330

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. PubMed ID: 19304925

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. PubMed ID: 19383768

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. PubMed ID: 21981923

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. PubMed ID: 21984185

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. PubMed ID: 21984184

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315