Details for: ADGRB3

Gene ID: 577

Symbol: ADGRB3

Ensembl ID: ENSG00000135298

Description: adhesion G protein-coupled receptor B3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 6.41
    Marker Score: 7,986
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.81
    Marker Score: 3,820
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 5.29
    Marker Score: 2,940
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.88
    Marker Score: 22,598
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.88
    Marker Score: 9,299
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.83
    Marker Score: 8,401
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.31
    Marker Score: 1,794
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.28
    Marker Score: 1,042
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69,751
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 3.21
    Marker Score: 5,456
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.18
    Marker Score: 9,077
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.15
    Marker Score: 5,296
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.93
    Marker Score: 3,374
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58,155
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,104
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.87
    Marker Score: 42,851
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104,446
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.67
    Marker Score: 2,315
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10,882
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,736
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.43
    Marker Score: 1,448
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.4
    Marker Score: 2,969
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9,155
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.23
    Marker Score: 1,081
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,689
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.18
    Marker Score: 1,747
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.18
    Marker Score: 913
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.1
    Marker Score: 21,675
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 128,031
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.01
    Marker Score: 903
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.97
    Marker Score: 711
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.96
    Marker Score: 7,974
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,348
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.88
    Marker Score: 515
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,177
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.79
    Marker Score: 1,703
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.7
    Marker Score: 3,456
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.67
    Marker Score: 487
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,560
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.6
    Marker Score: 415
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.55
    Marker Score: 930
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.54
    Marker Score: 900
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.43
    Marker Score: 710
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.41
    Marker Score: 531
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.41
    Marker Score: 489
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.38
    Marker Score: 666
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.36
    Marker Score: 759
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.29
    Marker Score: 5,417
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.29
    Marker Score: 405
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19,516
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.24
    Marker Score: 1,230
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.2
    Marker Score: 2,070
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.18
    Marker Score: 480
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,672
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.15
    Marker Score: 4,802
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.14
    Marker Score: 360
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.1
    Marker Score: 1,240
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2,570
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.04
    Marker Score: 6,225
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.03
    Marker Score: 546
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.02
    Marker Score: 671
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1
    Marker Score: 1,929
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.99
    Marker Score: 113,978
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2,471
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.96
    Marker Score: 600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.96
    Marker Score: 1,191
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,321
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.93
    Marker Score: 444
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.92
    Marker Score: 869
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.9
    Marker Score: 831
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.89
    Marker Score: 682
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.88
    Marker Score: 521
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.84
    Marker Score: 898
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.83
    Marker Score: 1,682
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.83
    Marker Score: 10,987
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.8
    Marker Score: 352
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.79
    Marker Score: 1,434
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.77
    Marker Score: 2,993
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.73
    Marker Score: 886
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.7
    Marker Score: 766
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.69
    Marker Score: 652
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.68
    Marker Score: 230
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.68
    Marker Score: 366
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.68
    Marker Score: 342
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.65
    Marker Score: 789
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.64
    Marker Score: 182
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1,207
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.62
    Marker Score: 160
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 477
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.59
    Marker Score: 696
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.59
    Marker Score: 174
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADGRB3 is a member of the G protein-coupled receptor (GPCR) family and is characterized by its unique structure, which allows it to interact with various ligands and modulate downstream signaling pathways. The receptor is primarily expressed in cells of the nervous system, including neurons, astrocytes, and oligodendrocytes, as well as in immune cells such as cardiac neurons and inhibitory interneurons. ADGRB3 is also found in non-neuronal tissues, including the alveolar type 2 fibroblast cells and mesenchymal cells. **Pathways and Functions:** ADGRB3 is involved in several signaling pathways that regulate immune responses, neuronal development, and synaptic function. The most notable pathways include: 1. **Adenylate cyclase-activating GPCR signaling pathway:** ADGRB3 activates adenylate cyclase, leading to increased cAMP levels and modulation of downstream signaling pathways. 2. **G protein-coupled receptor activity:** ADGRB3 interacts with G proteins to modulate downstream signaling pathways, including those involved in immune responses and neuronal development. 3. **GTPase activator activity:** ADGRB3 acts as a GTPase activator, regulating the activity of GTPases and modulating downstream signaling pathways. 4. **Maintenance of synapse structure:** ADGRB3 is involved in the regulation of synaptic structure and function, including the formation and maturation of synapses. 5. **Regulation of dendrite morphogenesis:** ADGRB3 modulates the development and morphology of dendrites, a critical aspect of neuronal function. **Clinical Significance:** ADGRB3 has been implicated in various neurological and immune disorders, including: 1. **Multiple Sclerosis (MS):** ADGRB3 has been shown to play a role in the regulation of immune responses and synapse dysfunction in MS. 2. **Autism Spectrum Disorder (ASD):** ADGRB3 has been implicated in the regulation of synaptic function and neuronal development in ASD. 3. **Cerebellar disorders:** ADGRB3 has been shown to play a role in the regulation of cerebellar function and coordination. 4. **Angiogenesis:** ADGRB3 has been implicated in the regulation of angiogenesis, a critical process in wound healing and tumor growth. In conclusion, ADGRB3 is a multifunctional receptor that plays a critical role in immune regulation, neuronal development, and synaptic function. Further research is needed to fully elucidate the mechanisms by which ADGRB3 regulates immune responses and neurological functions, and to explore its therapeutic potential in various diseases.

Genular Protein ID: 306822962

Symbol: AGRB3_HUMAN

Name: Brain-specific angiogenesis inhibitor 3

UniProtKB Accession Codes:

O60242 B7Z1K0 O60297 Q2NKN6 Q5VY37 Q9BX54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9533023

Title: Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).

PubMed ID: 9533023

DOI: 10.1159/000134693

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21262840

Title: The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.

PubMed ID: 21262840

DOI: 10.1073/pnas.1019577108

PubMed ID: 24567399

Title: G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.

PubMed ID: 24567399

DOI: 10.1073/pnas.1313886111

PubMed ID: 22333914

Title: A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.

PubMed ID: 22333914

DOI: 10.1038/emboj.2012.26

PubMed ID: 25713288

Title: International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors.

PubMed ID: 25713288

DOI: 10.1124/pr.114.009647

Sequence Information:

  • Length: 1522
  • Mass: 171518
  • Checksum: D22D0A5CF59E811F
  • Sequence:
    • MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK NFTNCTWTLE 
NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD LLRKNHSIMQ LCNSKNAFVF 
LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK SFFEFLVLNK VSPSQFGCHV LCTWLESCLK 
SENGRTESCG IMYTKCTCPQ HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC 
NLTREAKRPP KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 
STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE WSPWSLCSFT 
CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD GQWQEWSSWS QCSVTCSNGT 
QQRSRQCTAA AHGGSECRGP WAESRECYNP ECTANGQWNQ WGHWSGCSKS CDGGWERRIR 
TCQGAVITGQ QCEGTGEEVR RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN 
ATGTTSRRCS LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 
TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS NLLDEENKEK 
WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG NVVASIQKLP AASVLTDINF 
PMKGRKGMVD WARNSEDRVV IPKSIFTPVS SKELDESSVF VLGAVLYKNL DLILPTLRNY 
TVINSKIIVV TIRPEPKTTD SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK 
TVLTDASHTK CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA 
ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF FFLASFCWVL 
TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG FTRTKGYGTD HYCWLSLEGG 
LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR DGILDKKLKH RAGQMSEPHS GLTLKCAKCG 
VVSTTALSAT TASNAMASLW SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG 
FVIVMVHCIL RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 
HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII QQPTGLHMPM 
SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ ERMMESDYIV MPRSSVNNQP 
SMKEESKMNI GMETLPHERL LHYKVNPEFN MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP 
RTAVKNFMAS ELDDNAGLSR SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE 
LNQKFQTLDR FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP 
AEWEKCLNLP LDVQEGDFQT EV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.