Details for: ADGRB3

Gene ID: 577

Symbol: ADGRB3

Ensembl ID: ENSG00000135298

Description: adhesion G protein-coupled receptor B3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 438.7615
    Cell Significance Index: -178.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.0247
    Cell Significance Index: -37.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 7.6639
    Cell Significance Index: 2748.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 7.6506
    Cell Significance Index: 167.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 7.2187
    Cell Significance Index: 443.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 6.8704
    Cell Significance Index: 164.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 6.6936
    Cell Significance Index: 450.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 6.3242
    Cell Significance Index: 354.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.2074
    Cell Significance Index: 177.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.0397
    Cell Significance Index: 267.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.6523
    Cell Significance Index: 214.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 4.7962
    Cell Significance Index: 3317.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 4.3040
    Cell Significance Index: 863.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.7070
    Cell Significance Index: 46.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.3555
    Cell Significance Index: 1069.0700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.0746
    Cell Significance Index: 29.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4304
    Cell Significance Index: 273.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1844
    Cell Significance Index: 347.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0736
    Cell Significance Index: 100.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0623
    Cell Significance Index: -95.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1038
    Cell Significance Index: -191.5100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1221
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.2745
    Cell Significance Index: -203.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2827
    Cell Significance Index: -41.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.3013
    Cell Significance Index: -228.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.3419
    Cell Significance Index: -151.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3488
    Cell Significance Index: -17.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.3735
    Cell Significance Index: -203.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.4047
    Cell Significance Index: -252.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.4171
    Cell Significance Index: -235.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5713
    Cell Significance Index: -164.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6775
    Cell Significance Index: -27.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.7990
    Cell Significance Index: -144.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9180
    Cell Significance Index: -39.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0434
    Cell Significance Index: -26.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -1.0520
    Cell Significance Index: -208.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -1.1611
    Cell Significance Index: -244.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -1.2872
    Cell Significance Index: -158.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -1.3299
    Cell Significance Index: -170.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -1.4176
    Cell Significance Index: -194.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.4577
    Cell Significance Index: -151.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -1.4803
    Cell Significance Index: -252.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -1.5779
    Cell Significance Index: -203.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.5798
    Cell Significance Index: -44.1500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.6374
    Cell Significance Index: -22.9500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.8472
    Cell Significance Index: -21.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.8848
    Cell Significance Index: -219.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.9631
    Cell Significance Index: -28.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -1.9751
    Cell Significance Index: -201.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.9784
    Cell Significance Index: -39.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.9954
    Cell Significance Index: -228.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.0941
    Cell Significance Index: -165.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -2.1375
    Cell Significance Index: -151.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.2356
    Cell Significance Index: -171.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.3422
    Cell Significance Index: -49.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.3592
    Cell Significance Index: -33.7900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -2.3935
    Cell Significance Index: -31.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.6240
    Cell Significance Index: -85.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -2.6542
    Cell Significance Index: -25.1600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -2.6738
    Cell Significance Index: -25.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.7150
    Cell Significance Index: -86.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.7159
    Cell Significance Index: -54.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.8829
    Cell Significance Index: -151.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -3.3028
    Cell Significance Index: -172.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -3.3132
    Cell Significance Index: -213.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -3.4359
    Cell Significance Index: -23.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.4533
    Cell Significance Index: -211.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -3.5566
    Cell Significance Index: -44.3500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -3.5953
    Cell Significance Index: -47.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -3.6033
    Cell Significance Index: -41.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.6481
    Cell Significance Index: -127.8000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -3.7429
    Cell Significance Index: -47.2400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -3.7495
    Cell Significance Index: -64.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -3.7938
    Cell Significance Index: -239.1100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -3.9091
    Cell Significance Index: -28.4200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -4.1034
    Cell Significance Index: -51.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -4.2034
    Cell Significance Index: -197.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -4.3202
    Cell Significance Index: -93.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -4.4406
    Cell Significance Index: -207.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -4.4611
    Cell Significance Index: -111.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -4.5285
    Cell Significance Index: -205.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -4.6011
    Cell Significance Index: -96.0300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -4.6062
    Cell Significance Index: -28.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -4.9184
    Cell Significance Index: -55.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -5.0098
    Cell Significance Index: -174.0900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -5.0158
    Cell Significance Index: -60.8000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -5.3467
    Cell Significance Index: -63.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.5577
    Cell Significance Index: -204.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.9204
    Cell Significance Index: -174.3800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -5.9739
    Cell Significance Index: -35.4500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -5.9990
    Cell Significance Index: -64.3200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -6.5079
    Cell Significance Index: -86.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -6.5737
    Cell Significance Index: -81.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -6.6943
    Cell Significance Index: -235.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -6.8123
    Cell Significance Index: -134.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -6.9219
    Cell Significance Index: -140.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -7.0986
    Cell Significance Index: -203.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -7.2963
    Cell Significance Index: -214.2900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -7.3272
    Cell Significance Index: -55.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -7.4915
    Cell Significance Index: -156.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADGRB3 is a member of the G protein-coupled receptor (GPCR) family and is characterized by its unique structure, which allows it to interact with various ligands and modulate downstream signaling pathways. The receptor is primarily expressed in cells of the nervous system, including neurons, astrocytes, and oligodendrocytes, as well as in immune cells such as cardiac neurons and inhibitory interneurons. ADGRB3 is also found in non-neuronal tissues, including the alveolar type 2 fibroblast cells and mesenchymal cells. **Pathways and Functions:** ADGRB3 is involved in several signaling pathways that regulate immune responses, neuronal development, and synaptic function. The most notable pathways include: 1. **Adenylate cyclase-activating GPCR signaling pathway:** ADGRB3 activates adenylate cyclase, leading to increased cAMP levels and modulation of downstream signaling pathways. 2. **G protein-coupled receptor activity:** ADGRB3 interacts with G proteins to modulate downstream signaling pathways, including those involved in immune responses and neuronal development. 3. **GTPase activator activity:** ADGRB3 acts as a GTPase activator, regulating the activity of GTPases and modulating downstream signaling pathways. 4. **Maintenance of synapse structure:** ADGRB3 is involved in the regulation of synaptic structure and function, including the formation and maturation of synapses. 5. **Regulation of dendrite morphogenesis:** ADGRB3 modulates the development and morphology of dendrites, a critical aspect of neuronal function. **Clinical Significance:** ADGRB3 has been implicated in various neurological and immune disorders, including: 1. **Multiple Sclerosis (MS):** ADGRB3 has been shown to play a role in the regulation of immune responses and synapse dysfunction in MS. 2. **Autism Spectrum Disorder (ASD):** ADGRB3 has been implicated in the regulation of synaptic function and neuronal development in ASD. 3. **Cerebellar disorders:** ADGRB3 has been shown to play a role in the regulation of cerebellar function and coordination. 4. **Angiogenesis:** ADGRB3 has been implicated in the regulation of angiogenesis, a critical process in wound healing and tumor growth. In conclusion, ADGRB3 is a multifunctional receptor that plays a critical role in immune regulation, neuronal development, and synaptic function. Further research is needed to fully elucidate the mechanisms by which ADGRB3 regulates immune responses and neurological functions, and to explore its therapeutic potential in various diseases.

Genular Protein ID: 306822962

Symbol: AGRB3_HUMAN

Name: Brain-specific angiogenesis inhibitor 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9533023

Title: Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).

PubMed ID: 9533023

DOI: 10.1159/000134693

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21262840

Title: The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.

PubMed ID: 21262840

DOI: 10.1073/pnas.1019577108

PubMed ID: 24567399

Title: G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.

PubMed ID: 24567399

DOI: 10.1073/pnas.1313886111

PubMed ID: 22333914

Title: A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.

PubMed ID: 22333914

DOI: 10.1038/emboj.2012.26

PubMed ID: 25713288

Title: International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors.

PubMed ID: 25713288

DOI: 10.1124/pr.114.009647

Sequence Information:

  • Length: 1522
  • Mass: 171518
  • Checksum: D22D0A5CF59E811F
  • Sequence:
  • MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK NFTNCTWTLE 
    NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD LLRKNHSIMQ LCNSKNAFVF 
    LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK SFFEFLVLNK VSPSQFGCHV LCTWLESCLK 
    SENGRTESCG IMYTKCTCPQ HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC 
    NLTREAKRPP KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 
    STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE WSPWSLCSFT 
    CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD GQWQEWSSWS QCSVTCSNGT 
    QQRSRQCTAA AHGGSECRGP WAESRECYNP ECTANGQWNQ WGHWSGCSKS CDGGWERRIR 
    TCQGAVITGQ QCEGTGEEVR RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN 
    ATGTTSRRCS LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 
    TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS NLLDEENKEK 
    WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG NVVASIQKLP AASVLTDINF 
    PMKGRKGMVD WARNSEDRVV IPKSIFTPVS SKELDESSVF VLGAVLYKNL DLILPTLRNY 
    TVINSKIIVV TIRPEPKTTD SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK 
    TVLTDASHTK CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA 
    ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF FFLASFCWVL 
    TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG FTRTKGYGTD HYCWLSLEGG 
    LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR DGILDKKLKH RAGQMSEPHS GLTLKCAKCG 
    VVSTTALSAT TASNAMASLW SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG 
    FVIVMVHCIL RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 
    HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII QQPTGLHMPM 
    SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ ERMMESDYIV MPRSSVNNQP 
    SMKEESKMNI GMETLPHERL LHYKVNPEFN MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP 
    RTAVKNFMAS ELDDNAGLSR SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE 
    LNQKFQTLDR FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP 
    AEWEKCLNLP LDVQEGDFQT EV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.