Details for: METTL14

Gene ID: 57721

Symbol: METTL14

Ensembl ID: ENSG00000145388

Description: methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

Associated with

Other Information

Genular Protein ID: 2395604110

Symbol: MET14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24407421

Title: Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.

PubMed ID: 24407421

DOI: 10.1038/cr.2014.3

PubMed ID: 24981863

Title: Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.

PubMed ID: 24981863

DOI: 10.1016/j.celrep.2014.05.048

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24316715

Title: A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation.

PubMed ID: 24316715

DOI: 10.1038/nchembio.1432

PubMed ID: 25719671

Title: N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.

PubMed ID: 25719671

DOI: 10.1038/nature14234

PubMed ID: 26458103

Title: Dynamic m(6)A mRNA methylation directs translational control of heat shock response.

PubMed ID: 26458103

DOI: 10.1038/nature15377

PubMed ID: 29507755

Title: VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.

PubMed ID: 29507755

DOI: 10.1038/s41421-018-0019-0

PubMed ID: 29348140

Title: Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.

PubMed ID: 29348140

DOI: 10.1261/rna.064063.117

PubMed ID: 27627798

Title: Structural insights into the molecular mechanism of the m(6)A writer complex.

PubMed ID: 27627798

DOI: 10.7554/elife.18434

PubMed ID: 27373337

Title: Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases.

PubMed ID: 27373337

DOI: 10.1016/j.molcel.2016.05.041

PubMed ID: 27281194

Title: Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.

PubMed ID: 27281194

DOI: 10.1038/nature18298

Sequence Information:

  • Length: 456
  • Mass: 52150
  • Checksum: 73A45B66BB76E241
  • Sequence:
  • MDSRLQEIRE RQKLRRQLLA QQLGAESADS IGAVLNSKDE QREIAETRET CRASYDTSAP 
    NAKRKYLDEG ETDEDKMEEY KDELEMQQDE ENLPYEEEIY KDSSTFLKGT QSLNPHNDYC 
    QHFVDTGHRP QNFIRDVGLA DRFEEYPKLR ELIRLKDELI AKSNTPPMYL QADIEAFDIR 
    ELTPKFDVIL LEPPLEEYYR ETGITANEKC WTWDDIMKLE IDEIAAPRSF IFLWCGSGEG 
    LDLGRVCLRK WGYRRCEDIC WIKTNKNNPG KTKTLDPKAV FQRTKEHCLM GIKGTVKRST 
    DGDFIHANVD IDLIITEEPE IGNIEKPVEI FHIIEHFCLG RRRLHLFGRD STIRPGWLTV 
    GPTLTNSNYN AETYASYFSA PNSYLTGCTE EIERLRPKSP PPKSKSDRGG GAPRGGGRGG 
    TSAGRGRERN RSNFRGERGG FRGGRGGAHR GGFPPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.