Details for: Piwil2

Gene ID: 57746

Symbol: Piwil2

Ensembl ID: ENSMUSG00000033644

Description: piwi-like RNA-mediated gene silencing 2

Associated with

Other Information

Genular Protein ID: 4236572593

Symbol: PIWL2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CDG1 A6H617 Q3TQE8 Q99MV6 Q9JMB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 2 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 11578866

Title: Two mouse piwi-related genes: miwi and mili.

PubMed ID: 11578866

DOI: 10.1016/s0925-4773(01)00499-3

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279525

Title: An abundance of X-linked genes expressed in spermatogonia.

PubMed ID: 11279525

DOI: 10.1038/86927

PubMed ID: 12906857

Title: Identification of eight members of the Argonaute family in the human genome.

PubMed ID: 12906857

DOI: 10.1016/s0888-7543(03)00129-0

PubMed ID: 14736746

Title: Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.

PubMed ID: 14736746

DOI: 10.1242/dev.00973

PubMed ID: 16261612

Title: Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes.

PubMed ID: 16261612

DOI: 10.1002/mrd.20391

PubMed ID: 16751777

Title: A novel class of small RNAs bind to MILI protein in mouse testes.

PubMed ID: 16751777

DOI: 10.1038/nature04916

PubMed ID: 16787967

Title: Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

PubMed ID: 16787967

DOI: 10.1093/hmg/ddl158

PubMed ID: 17446352

Title: Developmentally regulated piRNA clusters implicate MILI in transposon control.

PubMed ID: 17446352

DOI: 10.1126/science.1142612

PubMed ID: 18381894

Title: DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.

PubMed ID: 18381894

DOI: 10.1101/gad.1640708

PubMed ID: 18404146

Title: Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes.

PubMed ID: 18404146

DOI: 10.1038/nature06908

PubMed ID: 18922463

Title: A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

PubMed ID: 18922463

DOI: 10.1016/j.molcel.2008.09.003

PubMed ID: 19345100

Title: Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.

PubMed ID: 19345100

DOI: 10.1016/j.cub.2009.02.061

PubMed ID: 19584108

Title: Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

PubMed ID: 19584108

DOI: 10.1101/gad.1814809

PubMed ID: 19114715

Title: MILI, a PIWI-interacting RNA-binding protein, is required for germ Line stem cell self-renewal and appears to positively regulate translation.

PubMed ID: 19114715

DOI: 10.1074/jbc.m809104200

PubMed ID: 19377467

Title: Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.

PubMed ID: 19377467

DOI: 10.1038/ncb1872

PubMed ID: 19465913

Title: Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.

PubMed ID: 19465913

DOI: 10.1038/nsmb.1615

PubMed ID: 19918066

Title: Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

PubMed ID: 19918066

DOI: 10.1073/pnas.0911640106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20439430

Title: MVH in piRNA processing and gene silencing of retrotransposons.

PubMed ID: 20439430

DOI: 10.1101/gad.1902110

PubMed ID: 20534472

Title: Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

PubMed ID: 20534472

DOI: 10.1073/pnas.1003953107

PubMed ID: 20547853

Title: MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.

PubMed ID: 20547853

DOI: 10.1073/pnas.1007158107

PubMed ID: 22020280

Title: The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.

PubMed ID: 22020280

DOI: 10.1038/nature10547

PubMed ID: 24067652

Title: Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.

PubMed ID: 24067652

DOI: 10.1073/pnas.1316316110

PubMed ID: 23706823

Title: Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis.

PubMed ID: 23706823

DOI: 10.1016/j.molcel.2013.04.026

PubMed ID: 23611983

Title: GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells.

PubMed ID: 23611983

DOI: 10.1261/rna.038521.113

PubMed ID: 26669262

Title: PIWI slicing and EXD1 drive biogenesis of nuclear piRNAs from cytosolic targets of the mouse piRNA pathway.

PubMed ID: 26669262

DOI: 10.1016/j.molcel.2015.11.009

PubMed ID: 28633017

Title: Distinct roles of RNA helicases MVH and TDRD9 in PIWI slicing-triggered mammalian piRNA biogenesis and function.

PubMed ID: 28633017

DOI: 10.1016/j.devcel.2017.05.021

PubMed ID: 28254886

Title: Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.

PubMed ID: 28254886

DOI: 10.1242/jcs.188763

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 32381626

Title: TEX15 associates with MILI and silences transposable elements in male germ cells.

PubMed ID: 32381626

DOI: 10.1101/gad.335489.119

PubMed ID: 22996915

Title: The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors.

PubMed ID: 22996915

DOI: 10.1261/rna.034181.112

Sequence Information:

  • Length: 971
  • Mass: 109488
  • Checksum: 01E143C6513310FB
  • Sequence:
    • MDPVRPLFRG PTPVHPSQCV RMPGCWPQAP RPLEPAWGRA GPAGRGLVFR KPEDSSPPLQ 
PVQKDSVGLV SMFRGMGLDT AFRPPSKREV PPLGRGVLGR GLSANMVRKD REEPRSSLPD 
PSVLAAGDSK LAEASVGWSR MLGRGSSEVS LLPLGRAASS IGRGMDKPPS AFGLTARDPP 
RLPQPPALSP TSLHSADPPP VLTMERKEKE LLVKQGSKGT PQSLGLNLIK IQCHNEAVYQ 
YHVTFSPSVE CKSMRFGMLK DHQSVTGNVT AFDGSILYLP VKLQQVVELK SQRKTDDAEI 
SIKIQLTKIL EPCSDLCIPF YNVVFRRVMK LLDMKLVGRN FYDPTSAMVL QQHRLQIWPG 
YAASIRRTDG GLFLLADVSH KVIRNDSVLD VMHAIYQQNK EHFQDECSKL LVGSIVITRY 
NNRTYRIDDV DWNKTPKDSF VMSDGKEITF LEYYSKNYGI TVKEDDQPLL IHRPSERQNN 
HGMLLKGEIL LLPELSFMTG IPEKMKKDFR AMKDLTQQIN LSPKQHHGAL ECLLQRISQN 
ETASNELTRW GLSLHKDVHK IEGRLLPMER INLRNTSFVT SEDLNWVKEV TRDASILTIP 
MHFWALFYPK RAMDQARELV NMLEKIAGPI GMRISPPAWV ELKDDRIETY IRTIQSLLGV 
EGKIQMVVCI IMGTRDDLYG AIKKLCCVQS PVPSQVINVR TIGQPTRLRS VAQKILLQMN 
CKLGGELWGV DIPLKQLMVI GMDVYHDPSR GMRSVVGFVA SINLTLTKWY SRVVFQMPHQ 
EIVDSLKLCL VGSLKKYYEV NHCLPEKIVV YRDGVSDGQL KTVANYEIPQ LQKCFEAFDN 
YHPKMVVFVV QKKISTNLYL AAPDHFVTPS PGTVVDHTIT SCEWVDFYLL AHHVRQGCGI 
PTHYICVLNT ANLSPDHMQR LTFKLCHMYW NWPGTIRVPA PCKYAHKLAF LSGQILHHEP 
AIQLCGNLFF L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.