Details for: Piwil1

Gene ID: 57749

Symbol: Piwil1

Ensembl ID: ENSMUSG00000029423

Description: piwi-like RNA-mediated gene silencing 1

Associated with

Other Information

Genular Protein ID: 3483455605

Symbol: PIWL1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11578866

Title: Two mouse piwi-related genes: miwi and mili.

PubMed ID: 11578866

DOI: 10.1016/s0925-4773(01)00499-3

PubMed ID: 12062093

Title: miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis.

PubMed ID: 12062093

DOI: 10.1016/s1534-5807(02)00165-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16766680

Title: A novel class of small RNAs in mouse spermatogenic cells.

PubMed ID: 16766680

DOI: 10.1101/gad.1434406

PubMed ID: 16787948

Title: Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells.

PubMed ID: 16787948

DOI: 10.1242/jcs.03022

PubMed ID: 16751776

Title: A germline-specific class of small RNAs binds mammalian Piwi proteins.

PubMed ID: 16751776

DOI: 10.1038/nature04917

PubMed ID: 16787967

Title: Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

PubMed ID: 16787967

DOI: 10.1093/hmg/ddl158

PubMed ID: 16938833

Title: MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis.

PubMed ID: 16938833

DOI: 10.1073/pnas.0605506103

PubMed ID: 19020299

Title: Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.

PubMed ID: 19020299

DOI: 10.1095/biolreprod.108.072553

PubMed ID: 19584108

Title: Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

PubMed ID: 19584108

DOI: 10.1101/gad.1814809

PubMed ID: 19377467

Title: Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.

PubMed ID: 19377467

DOI: 10.1038/ncb1872

PubMed ID: 19465913

Title: Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.

PubMed ID: 19465913

DOI: 10.1038/nsmb.1615

PubMed ID: 19918066

Title: Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

PubMed ID: 19918066

DOI: 10.1073/pnas.0911640106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20534472

Title: Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

PubMed ID: 20534472

DOI: 10.1073/pnas.1003953107

PubMed ID: 19926723

Title: Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization.

PubMed ID: 19926723

DOI: 10.1261/rna.1869710

PubMed ID: 22900038

Title: Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells.

PubMed ID: 22900038

DOI: 10.1371/journal.pone.0042695

PubMed ID: 23714778

Title: Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline.

PubMed ID: 23714778

DOI: 10.1038/emboj.2013.121

PubMed ID: 22121019

Title: Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.

PubMed ID: 22121019

DOI: 10.1038/nature10672

PubMed ID: 23328397

Title: piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis.

PubMed ID: 23328397

DOI: 10.1016/j.devcel.2012.12.006

PubMed ID: 23523368

Title: An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.

PubMed ID: 23523368

DOI: 10.1016/j.molcel.2013.02.016

PubMed ID: 28552346

Title: Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis.

PubMed ID: 28552346

DOI: 10.1016/j.cell.2017.04.034

PubMed ID: 28254886

Title: Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.

PubMed ID: 28254886

DOI: 10.1242/jcs.188763

PubMed ID: 21237665

Title: Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein.

PubMed ID: 21237665

DOI: 10.1016/j.str.2010.11.015

PubMed ID: 24757166

Title: The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs.

PubMed ID: 24757166

DOI: 10.1261/rna.044701.114

Sequence Information:

  • Length: 862
  • Mass: 98574
  • Checksum: 45588D13284CCC4C
  • Sequence:
  • MTGRARARAR GRARGQETVQ HVGAAASQQP GYIPPRPQQS PTEGDLVGRG RQRGMVVGAT 
    SKSQELQISA GFQELSLAER GGRRRDFHDL GVNTRQNLDH VKESKTGSSG IIVKLSTNHF 
    RLTSRPQWAL YQYHIDYNPL MEARRLRSAL LFQHEDLIGR CHAFDGTILF LPKRLQHKVT 
    EVFSQTRNGE HVRITITLTN ELPPTSPTCL QFYNIIFRRL LKIMNLQQIG RNYYNPSDPI 
    DIPNHRLVIW PGFTTSILQY ENNIMLCTDV SHKVLRSETV LDFMFNLYQQ TEEHKFQEQV 
    SKELIGLIVL TKYNNKTYRV DDIDWDQNPK STFKKADGSE VSFLEYYRKQ YNQEITDLKQ 
    PVLVSQPKRR RGPGGTLPGP AMLIPELCYL TGLTDKMRND FNVMKDLAVH TRLTPEQRQR 
    EVGRLIDYIH KDDNVQRELR DWGLSFDSNL LSFSGRILQS EKIHQGGKTF DYNPQFADWS 
    KETRGAPLIS VKPLDNWLLI YTRRNYEAAN SLIQNLFKVT PAMGIQMKKA IMIEVDDRTE 
    AYLRALQQKV TSDTQIVVCL LSSNRKDKYD AIKKYLCTDC PTPSQCVVAR TLGKQQTVMA 
    IATKIALQMN CKMGGELWRV DMPLKLAMIV GIDCYHDTTA GRRSIAGFVA SINEGMTRWF 
    SRCVFQDRGQ ELVDGLKVCL QAALRAWSGC NEYMPSRVIV YRDGVGDGQL KTLVNYEVPQ 
    FLDCLKSVGR GYNPRLTVIV VKKRVNARFF AQSGGRLQNP LPGTVIDVEV TRPEWYDFFI 
    VSQAVRSGSV SPTHYNVIYD SSGLKPDHIQ RLTYKLCHVY YNWPGVIRVP APCQYAHKLA 
    FLVGQSIHRE PNLSLSNRLY YL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.