Details for: SCUBE2

Gene ID: 57758

Symbol: SCUBE2

Ensembl ID: ENSG00000175356

Description: signal peptide, CUB domain and EGF like domain containing 2

Associated with

Other Information

Genular Protein ID: 4115735559

Symbol: SCUB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11528127

Title: Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.

PubMed ID: 11528127

DOI: 10.1159/000056999

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12270931

Title: Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.

PubMed ID: 12270931

DOI: 10.1074/jbc.m207410200

PubMed ID: 19480626

Title: Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans.

PubMed ID: 19480626

DOI: 10.1042/bj20090341

PubMed ID: 22902404

Title: Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.

PubMed ID: 22902404

DOI: 10.1016/j.celrep.2012.07.010

PubMed ID: 22677548

Title: Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.

PubMed ID: 22677548

DOI: 10.1101/gad.191866.112

PubMed ID: 24522195

Title: Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells.

PubMed ID: 24522195

DOI: 10.1242/jcs.137695

PubMed ID: 26875496

Title: Hedgehog receptor function during craniofacial development.

PubMed ID: 26875496

DOI: 10.1016/j.ydbio.2016.02.009

PubMed ID: 27834687

Title: Endothelial SCUBE2 interacts with VEGFR2 and regulates VEGF-induced angiogenesis.

PubMed ID: 27834687

DOI: 10.1161/atvbaha.116.308546

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

Sequence Information:

  • Length: 999
  • Mass: 109957
  • Checksum: 61334844A0053095
  • Sequence:
  • MGVAGRNRPG AAWAVLLLLL LLPPLLLLAG AVPPGRGRAA GPQEDVDECA QGLDDCHADA 
    LCQNTPTSYK CSCKPGYQGE GRQCEDIDEC GNELNGGCVH DCLNIPGNYR CTCFDGFMLA 
    HDGHNCLDVD ECLENNGGCQ HTCVNVMGSY ECCCKEGFFL SDNQHTCIHR SEEGLSCMNK 
    DHGCSHICKE APRGSVACEC RPGFELAKNQ RDCILTCNHG NGGCQHSCDD TADGPECSCH 
    PQYKMHTDGR SCLEREDTVL EVTESNTTSV VDGDKRVKRR LLMETCAVNN GGCDRTCKDT 
    STGVHCSCPV GFTLQLDGKT CKDIDECQTR NGGCDHFCKN IVGSFDCGCK KGFKLLTDEK 
    SCQDVDECSL DRTCDHSCIN HPGTFACACN RGYTLYGFTH CGDTNECSIN NGGCQQVCVN 
    TVGSYECQCH PGYKLHWNKK DCVEVKGLLP TSVSPRVSLH CGKSGGGDGC FLRCHSGIHL 
    SSDVTTIRTS VTFKLNEGKC SLKNAELFPE GLRPALPEKH SSVKESFRYV NLTCSSGKQV 
    PGAPGRPSTP KEMFITVEFE LETNQKEVTA SCDLSCIVKR TEKRLRKAIR TLRKAVHREQ 
    FHLQLSGMNL DVAKKPPRTS ERQAESCGVG QGHAENQCVS CRAGTYYDGA RERCILCPNG 
    TFQNEEGQMT CEPCPRPGNS GALKTPEAWN MSECGGLCQP GEYSADGFAP CQLCALGTFQ 
    PEAGRTSCFP CGGGLATKHQ GATSFQDCET RVQCSPGHFY NTTTHRCIRC PVGTYQPEFG 
    KNNCVSCPGN TTTDFDGSTN ITQCKNRRCG GELGDFTGYI ESPNYPGNYP ANTECTWTIN 
    PPPKRRILIV VPEIFLPIED DCGDYLVMRK TSSSNSVTTY ETCQTYERPI AFTSRSKKLW 
    IQFKSNEGNS ARGFQVPYVT YDEDYQELIE DIVRDGRLYA SENHQEILKD KKLIKALFDV 
    LAHPQNYFKY TAQESREMFP RSFIRLLRSK VSRFLRPYK

Genular Protein ID: 346056327

Symbol: B3KS09_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 447
  • Mass: 50309
  • Checksum: 4B5CA2FD00FBB6A0
  • Sequence:
  • MFITVEFELE TNQKEVTASC DLSCIVKRTE KRLRKAIRTL RKAVHREQFH LQLSGMNLDV 
    AKKPPRTSER QAESCGVGQG HAGNQCVSCR AGTYYDGARE RCILCPNGTF QNEEGQMTCE 
    PCPRPGNSGA LKTPEAWNMS ECGGLCQPGE YSADGFAPCQ LCALGTFQPE AGRTSCFPCG 
    GGLATKHQGA TSFQDCETRV QCSPGHFYNT TTHRCIRCPV GTYQPEFGKN NCVSCPGNTT 
    TDFDGSTNIT QCKNRRCGGE LGDFTGYIES PNYPGNYPAN TECTWTINPP PKRRILIVVP 
    EIFLPIEDDC GDYLVMRKTS SSNSVTTYET CQTYERPIAF TSRSKKLWIQ FKSNEGNSAR 
    GFQVPYVTYD EDYQELIEDI VRDGRLYASE NHQEILKDKK LIKALFDVLA HPQNYFKYTA 
    QESREMFPRS FIRLLRSKVS RFLRPYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.