TRIB3 | ENSG00000101255 | NCBI 57761

Details for: TRIB3

Gene ID: 57761

Symbol: TRIB3

Ensembl ID: ENSG00000101255

Description: tribbles pseudokinase 3

Associated with

Activation of akt2
(R-HSA-165158)
Adaptive immune system
(R-HSA-1280218)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Costimulation by the cd28 family
(R-HSA-388841)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k cascade
(R-HSA-109704)
Pip3 activates akt signaling
(R-HSA-1257604)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Response of eif2ak1 (hri) to heme deficiency
(R-HSA-9648895)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Atp binding
(GO:0005524)
Cellular response to insulin stimulus
(GO:0032869)
Cytosol
(GO:0005829)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Kinase activity
(GO:0016301)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of fatty acid biosynthetic process
(GO:0045717)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of ubiquitin-protein transferase activity
(GO:0051443)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Regulation of autophagy
(GO:0010506)
Regulation of glucose transmembrane transport
(GO:0010827)
Regulation of map kinase activity
(GO:0043405)
Response to endoplasmic reticulum stress
(GO:0034976)
Transcription corepressor activity
(GO:0003714)
Ubiquitin-protein transferase regulator activity
(GO:0055106)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Genular Protein ID: 321289763

Symbol: TRIB3_HUMAN

Name: Tribbles homolog 3

UniProtKB Accession Codes:

Q96RU7 Q53GU4 Q53ZW7 Q6I9Y9 Q8TAI6 Q9H5M8 Q9NUD2

Database IDs:

Citations:

PubMed ID: 12743605

Title: SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.

PubMed ID: 12743605

DOI: 10.1038/sj.onc.1206367

PubMed ID: 12736262

Title: SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.

PubMed ID: 12736262

DOI: 10.1074/jbc.m209814200

PubMed ID: 15299019

Title: Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.

PubMed ID: 15299019

DOI: 10.1074/jbc.m407732200

PubMed ID: 15781252

Title: Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions.

PubMed ID: 15781252

DOI: 10.1016/j.bbrc.2005.02.149

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15775988

Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

PubMed ID: 15775988

DOI: 10.1038/sj.emboj.7600596

PubMed ID: 16129579

Title: TRB3 is a PI 3-kinase dependent indicator for nutrient starvation.

PubMed ID: 16129579

DOI: 10.1016/j.cellsig.2005.08.002

PubMed ID: 17872950

Title: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.

PubMed ID: 17872950

DOI: 10.1074/jbc.m703735200

PubMed ID: 22977230

Title: Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.

PubMed ID: 22977230

DOI: 10.1074/jbc.m112.372722

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 358
Mass: 39578
Checksum: CE15FD89A81E8D63
Sequence:

MRATPLAAPA GSLSRKKRLE LDDNLDTERP VQKRARSGPQ PRLPPCLLPL SPPTAPDRAT 
AVATASRLGP YVLLEPEEGG RAYQALHCPT GTEYTCKVYP VQEALAVLEP YARLPPHKHV 
ARPTEVLAGT QLLYAFFTRT HGDMHSLVRS RHRIPEPEAA VLFRQMATAL AHCHQHGLVL 
RDLKLCRFVF ADRERKKLVL ENLEDSCVLT GPDDSLWDKH ACPAYVGPEI LSSRASYSGK 
AADVWSLGVA LFTMLAGHYP FQDSEPVLLF GKIRRGAYAL PAGLSAPARC LVRCLLRREP 
AERLTATGIL LHPWLRQDPM PLAPTRSHLW EAAQVVPDGL GLDEAREEEG DREVVLYG

Genular Protein ID: 3227374400

Symbol: J3KR25_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KR25

Database IDs:

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

Length: 385
Mass: 42757
Checksum: 46A0C1B6EB5E814C
Sequence:

MVLMHLAVKN NRMSANNDHF LTPTWQQMRA TPLAAPAGSL SRKKRLELDD NLDTERPVQK 
RARSGPQPRL PPCLLPLSPP TAPDRATAVA TASRLGPYVL LEPEEGGRAY QALHCPTGTE 
YTCKVYPVQE ALAVLEPYAR LPPHKHVARP TEVLAGTQLL YAFFTRTHGD MHSLVRSRHR 
IPEPEAAVLF RQMATALAHC HQHGLVLRDL KLCRFVFADR ERKKLVLENL EDSCVLTGPD 
DSLWDKHACP AYVGPEILSS RASYSGKAAD VWSLGVALFT MLAGHYPFQD SEPVLLFGKI 
RRGAYALPAG LSAPARCLVR CLLRREPAER LTATGILLHP WLRQDPMPLA PTRSHLWEAA 
QVVPDGLGLD EAREEEGDRE VVLYG

Genular Protein ID: 3275308290

Symbol: B4DMM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DMM9

Database IDs:

Sequence Information:

Length: 385
Mass: 42685
Checksum: 46A0C1B4CB7C814C
Sequence:

MVLMHLAVKN NRMSANNDHF LTPTWQQMRA TPLAAPAGSL SRKKRLELDD NLDTERPVQK 
RARSGPQPRL PPCLLPLSPP TAPDRATAVA TASRLGPYVL LEPEEGGRAY QALHCPTGTE 
YTCKVYPVQE ALAVLEPYAR LPPHKHVARP TEVLAGTQLL YAFFTRTHGD MHSLVRSRHR 
IPEPEAAVLF RQMATALAHC HQHGLVLRDL KLCRFVFADR ERKKLVLENL EDSCVLTGPD 
DSLWDKHACP AYVGPEILSS RASYSGKAAD VWSLGVALFT MLAGHYPFQD SEPVLLFGKI 
RRGAYALPAG LSAPARCLVR CLLRREPAER LTATGILLHP WLRQDPMPLA PTRSHLWGAA 
QVVPDGLGLD EAREEEGDRE VVLYG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIB3

Associated with

Other Information

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. PubMed ID: 12743605

SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. PubMed ID: 12736262

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. PubMed ID: 15299019

Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. PubMed ID: 15781252

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. PubMed ID: 15775988

TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. PubMed ID: 16129579

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. PubMed ID: 17872950

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A. PubMed ID: 22977230

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Database document:

PubMed ID: 12743605

PubMed ID: 12736262

PubMed ID: 15299019

PubMed ID: 15781252

PubMed ID: 14702039

PubMed ID: 11780052

PubMed ID: 15489334

PubMed ID: 15775988

PubMed ID: 16129579

PubMed ID: 17872950

PubMed ID: 22977230

PubMed ID: 23186163

PubMed ID: 17344846

PubMed ID: 11780052

PubMed ID: 23186163