Details for: Tbx21

Gene ID: 57765

Symbol: Tbx21

Ensembl ID: ENSMUSG00000001444

Description: T-box 21

Associated with

  • Cell fate specification
    (GO:0001708)
  • Cellular response to organic substance
    (GO:0071310)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Lymphocyte migration
    (GO:0072676)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of t-helper 2 cell cytokine production
    (GO:2000552)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of t-helper 17 cell lineage commitment
    (GO:2000329)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuronal cell body
    (GO:0043025)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of isotype switching to igg isotypes
    (GO:0048304)
  • Positive regulation of t-helper 1 cell cytokine production
    (GO:2000556)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of immune response
    (GO:0050776)
  • Regulation of t cell differentiation
    (GO:0045580)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • T-helper 1 cell lineage commitment
    (GO:0002296)
  • T cell differentiation
    (GO:0030217)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Other Information

Genular Protein ID: 2584344423

Symbol: TBX21_MOUSE

Name: T-box transcription factor TBX21

UniProtKB Accession Codes:

Q9JKD8 Q3U150 Q9R0A6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 1 GO 31 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10761931

Title: A novel transcription factor, T-bet, directs Th1 lineage commitment.

PubMed ID: 10761931

DOI: 10.1016/s0092-8674(00)80702-3

PubMed ID: 11087660

Title: Cloning and characterization of a new member of the T-box gene family.

PubMed ID: 11087660

DOI: 10.1006/geno.2000.6361

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15662016

Title: T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

PubMed ID: 15662016

DOI: 10.1126/science.1103336

PubMed ID: 17923685

Title: T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain.

PubMed ID: 17923685

DOI: 10.1128/mcb.01615-07

PubMed ID: 21095589

Title: Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.

PubMed ID: 21095589

DOI: 10.1016/j.molcel.2010.10.028

PubMed ID: 21690296

Title: c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation.

PubMed ID: 21690296

DOI: 10.1128/mcb.05383-11

PubMed ID: 21151104

Title: T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat.

PubMed ID: 21151104

DOI: 10.1038/ni.1969

PubMed ID: 23616576

Title: Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.

PubMed ID: 23616576

DOI: 10.4049/jimmunol.1203403

PubMed ID: 27292648

Title: T-bet activates Th1 genes through mediator and the super elongation complex.

PubMed ID: 27292648

DOI: 10.1016/j.celrep.2016.05.054

PubMed ID: 27430722

Title: Cutting Edge: B cell-intrinsic T-bet expression is required to control chronic viral infection.

PubMed ID: 27430722

DOI: 10.4049/jimmunol.1500368

PubMed ID: 28623086

Title: The transcription factor T-bet limits amplification of Type I IFN transcriptome and circuitry in T helper 1 cells.

PubMed ID: 28623086

DOI: 10.1016/j.immuni.2017.05.005

PubMed ID: 28424242

Title: mTORC1 Promotes T-bet phosphorylation to regulate Th1 differentiation.

PubMed ID: 28424242

DOI: 10.4049/jimmunol.1601078

PubMed ID: 28607488

Title: Stability and function of regulatory T cells expressing the transcription factor T-bet.

PubMed ID: 28607488

DOI: 10.1038/nature22360

Sequence Information:

  • Length: 530
  • Mass: 57852
  • Checksum: 07E4E9023A227FE8
  • Sequence:
    • MGIVEPGCGD MLTGTEPMPS DEGRGPGADQ QHRFFYPEPG AQDPTDRRAG SSLGTPYSGG 
ALVPAAPGRF LGSFAYPPRA QVAGFPGPGE FFPPPAGAEG YPPVDGYPAP DPRAGLYPGP 
REDYALPAGL EVSGKLRVAL SNHLLWSKFN QHQTEMIITK QGRRMFPFLS FTVAGLEPTS 
HYRMFVDVVL VDQHHWRYQS GKWVQCGKAE GSMPGNRLYV HPDSPNTGAH WMRQEVSFGK 
LKLTNNKGAS NNVTQMIVLQ SLHKYQPRLH IVEVNDGEPE AACSASNTHV FTFQETQFIA 
VTAYQNAEIT QLKIDNNPFA KGFRENFESM YASVDTSVPS PPGPNCQLLG GDPFSPLLSN 
QYPVPSRFYP DLPGQPKDMI SQPYWLGTPR EHSYEAEFRA VSMKPTLLPS APGPTVPYYR 
GQDVLAPGAG WPVAPQYPPK MSPAGWFRPM RTLPMDPGLG SSEEQGSSPS LWPEVTSLQP 
EPSDSGLGEG DTKRRRISPY PSSGDSSSPA GAPSPFDKET EGQFYNYFPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.