BAK1 | ENSG00000030110 | NCBI 578

Details for: BAK1

Gene ID: 578

Symbol: BAK1

Ensembl ID: ENSG00000030110

Description: BCL2 antagonist/killer 1

Associated with

Activation and oligomerization of bak protein
(R-HSA-111452)
Apoptosis
(R-HSA-109581)
Apoptotic factor-mediated response
(R-HSA-111471)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Programmed cell death
(R-HSA-5357801)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Release of apoptotic factors from the mitochondria
(R-HSA-111457)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Animal organ regeneration
(GO:0031100)
Apoptotic process
(GO:0006915)
Apoptotic process involved in blood vessel morphogenesis
(GO:1902262)
Apoptotic signaling pathway
(GO:0097190)
Bak complex
(GO:0097145)
B cell apoptotic process
(GO:0001783)
B cell homeostasis
(GO:0001782)
B cell negative selection
(GO:0002352)
Bcl-2 family protein complex
(GO:0097136)
Bh domain binding
(GO:0051400)
Blood vessel remodeling
(GO:0001974)
Calcium ion transport into cytosol
(GO:0060402)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to unfolded protein
(GO:0034620)
Cellular response to uv
(GO:0034644)
Cytosol
(GO:0005829)
Endocrine pancreas development
(GO:0031018)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum calcium ion homeostasis
(GO:0032469)
Epithelial cell proliferation
(GO:0050673)
Establishment of localization in cell
(GO:0051649)
Establishment or maintenance of transmembrane electrochemical gradient
(GO:0010248)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fibroblast apoptotic process
(GO:0044346)
Heat shock protein binding
(GO:0031072)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Limb morphogenesis
(GO:0035108)
Metal ion binding
(GO:0046872)
Mitochondrial fusion
(GO:0008053)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Molecular_function
(GO:0003674)
Myeloid cell homeostasis
(GO:0002262)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endoplasmic reticulum calcium ion concentration
(GO:0032471)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Pore complex
(GO:0046930)
Porin activity
(GO:0015288)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of endoplasmic reticulum unfolded protein response
(GO:1900103)
Positive regulation of ire1-mediated unfolded protein response
(GO:1903896)
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901030)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Post-embryonic camera-type eye morphogenesis
(GO:0048597)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of cell cycle
(GO:0051726)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Regulation of mitochondrial membrane potential
(GO:0051881)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to ethanol
(GO:0045471)
Response to fungus
(GO:0009620)
Response to gamma radiation
(GO:0010332)
Response to hydrogen peroxide
(GO:0042542)
Response to mycotoxin
(GO:0010046)
Response to organic cyclic compound
(GO:0014070)
Response to uv-c
(GO:0010225)
Response to xenobiotic stimulus
(GO:0009410)
Thymocyte apoptotic process
(GO:0070242)
Transmembrane transporter binding
(GO:0044325)
Vagina development
(GO:0060068)

Other Information

Proteins

Bcl-2 homologous antagonist/killer

Genular Protein ID: 1863433708

Symbol: BAK_HUMAN

Name: Bcl-2 homologous antagonist/killer

UniProtKB Accession Codes:

Q16611 C0H5Y7 Q6I9T6 Q92533

Database IDs:

Citations:

PubMed ID: 7715729

Title: Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K.

PubMed ID: 7715729

DOI: 10.1038/374731a0

PubMed ID: 7715730

Title: Induction of apoptosis by the Bcl-2 homologue Bak.

PubMed ID: 7715730

DOI: 10.1038/374733a0

PubMed ID: 7715731

Title: Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak.

PubMed ID: 7715731

DOI: 10.1038/374736a0

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8521816

Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

PubMed ID: 8521816

DOI: 10.1002/j.1460-2075.1995.tb00246.x

PubMed ID: 10233985

Title: Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak.

PubMed ID: 10233985

DOI: 10.1128/jvi.73.6.5181-5185.1999

PubMed ID: 16439990

Title: Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis.

PubMed ID: 16439990

DOI: 10.1038/sj.cdd.4401853

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 25296756

Title: Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.

PubMed ID: 25296756

DOI: 10.1074/jbc.m114.567792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 9020082

Title: Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

PubMed ID: 9020082

DOI: 10.1126/science.275.5302.983

PubMed ID: 17157251

Title: The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.

PubMed ID: 17157251

DOI: 10.1016/j.molcel.2006.10.014

PubMed ID: 17386268

Title: A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.

PubMed ID: 17386268

DOI: 10.1016/j.molcel.2007.02.004

Sequence Information:

Length: 211
Mass: 23409
Checksum: A2200FE72A46D04E
Sequence:

MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQEQEAE GVAAPADPEM 
VTLPLQPSST MGQVGRQLAI IGDDINRRYD SEFQTMLQHL QPTAENAYEY FTKIATSLFE 
SGINWGRVVA LLGFGYRLAL HVYQHGLTGF LGQVTRFVVD FMLHHCIARW IAQRGGWVAA 
LNLGNGPILN VLVVLGVVLL GQFVVRRFFK S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BAK1

Associated with

Other Information

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. PubMed ID: 7715729

Induction of apoptosis by the Bcl-2 homologue Bak. PubMed ID: 7715730

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. PubMed ID: 7715731

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. PubMed ID: 8521816

Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak. PubMed ID: 10233985

Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis. PubMed ID: 16439990

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Human Bop is a novel BH3-only member of the Bcl-2 protein family. PubMed ID: 23055042

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. PubMed ID: 25296756

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer. PubMed ID: 29531808

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. PubMed ID: 9020082

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. PubMed ID: 17157251

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak. PubMed ID: 17386268