Details for: BAK1

Gene ID: 578

Symbol: BAK1

Ensembl ID: ENSG00000030110

Description: BCL2 antagonist/killer 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.39
    Marker Score: 8862
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.21
    Marker Score: 5828
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2151
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1
    Marker Score: 3150
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71730
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47954
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15189
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.95
    Marker Score: 474
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2707
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.9
    Marker Score: 1191
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5243
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4888
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.84
    Marker Score: 303.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 505
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.78
    Marker Score: 761
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.76
    Marker Score: 3120
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.75
    Marker Score: 543
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.71
    Marker Score: 1101
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2959.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.7
    Marker Score: 170
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.69
    Marker Score: 1914
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 630
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.69
    Marker Score: 4388
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.68
    Marker Score: 5303
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.67
    Marker Score: 7793.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.66
    Marker Score: 6578.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.65
    Marker Score: 954
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.63
    Marker Score: 607
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.63
    Marker Score: 681
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.63
    Marker Score: 218
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.62
    Marker Score: 394
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.62
    Marker Score: 494
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.61
    Marker Score: 228
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.59
    Marker Score: 591
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.57
    Marker Score: 330
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.56
    Marker Score: 1524
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.55
    Marker Score: 4769.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.55
    Marker Score: 128
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.54
    Marker Score: 325
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.53
    Marker Score: 2619
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.53
    Marker Score: 931
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.53
    Marker Score: 184
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 424
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 349
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.53
    Marker Score: 526
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.52
    Marker Score: 532
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.52
    Marker Score: 2048
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.51
    Marker Score: 371
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.51
    Marker Score: 112
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.51
    Marker Score: 456.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.51
    Marker Score: 5126
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5
    Marker Score: 1863
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5
    Marker Score: 528
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5
    Marker Score: 1053
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.5
    Marker Score: 976
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.49
    Marker Score: 1554
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.49
    Marker Score: 857
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.49
    Marker Score: 1457
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 233
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.48
    Marker Score: 352
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.48
    Marker Score: 678.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.48
    Marker Score: 275
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 251
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.47
    Marker Score: 500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.47
    Marker Score: 354
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.47
    Marker Score: 104.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.47
    Marker Score: 312
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.47
    Marker Score: 1173
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.46
    Marker Score: 558
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 297
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.46
    Marker Score: 829
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.46
    Marker Score: 967
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.46
    Marker Score: 121.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.46
    Marker Score: 2807
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.46
    Marker Score: 254
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.46
    Marker Score: 515
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.46
    Marker Score: 25770
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.46
    Marker Score: 1094
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.46
    Marker Score: 386
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.46
    Marker Score: 112.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.46
    Marker Score: 259
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.46
    Marker Score: 724
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.45
    Marker Score: 493
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.45
    Marker Score: 773
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.45
    Marker Score: 885
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.45
    Marker Score: 11599.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.45
    Marker Score: 160
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.45
    Marker Score: 1026
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 695

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Other Information

## Summary The BAK1 gene encodes a protein known as BAK1, a BCL2 antagonist/killer. BCL2 is a protein that inhibits apoptosis, a form of programmed cell death. BAK1 is a protein that blocks the activity of BCL2, allowing apoptosis to proceed. ## Key characteristics * **Function:** BCL2 antagonist/killer * **Ensembl ID:** ENSG00000030110 * **Pathways/Ontology:** Activation and oligomerization of bak protein, Apoptosis, Apoptotic factor-mediated response, Heat shock protein binding, Identical protein binding, Intrinsic pathway for apoptosis, Metal ion binding, Molecular_function, Porin activity, Programmed cell death, Protein-containing complex binding, Protein binding, Protein heterodimerization activity, Protein homodimerization activity, Pyroptosis, Regulated necrosis, Release of apoptotic factors from the mitochondria, Transmembrane transporter binding ## Functions * **Inhibition of apoptosis:** BAK1 blocks the activity of BCL2, which inhibits apoptosis. * **Activation of the intrinsic pathway for apoptosis:** BAK1 is a key regulator of the intrinsic pathway for apoptosis, a pathway that is activated by the binding of certain ligands to death receptors on the surface of cells. * **Regulation of cell death:** BAK1 can also regulate cell death through the mitochondrial pathway, a pathway that is activated by the release of cytochrome c from mitochondria into the cytoplasm. ## Clinical significance Mutations in the BAK1 gene have been linked to a number of human cancers, including lung cancer, breast cancer, and leukemia. These mutations can lead to the activation of the intrinsic pathway for apoptosis, resulting in uncontrolled cell death. Targeting the BAK1 gene has been explored as a cancer treatment strategy.

Genular Protein ID: 1863433708

Symbol: BAK_HUMAN

Name: Bcl-2 homologous antagonist/killer

UniProtKB Accession Codes:

Q16611 C0H5Y7 Q6I9T6 Q92533

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 71 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 46 PDBsum 43 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7715729

Title: Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K.

PubMed ID: 7715729

DOI: 10.1038/374731a0

PubMed ID: 7715730

Title: Induction of apoptosis by the Bcl-2 homologue Bak.

PubMed ID: 7715730

DOI: 10.1038/374733a0

PubMed ID: 7715731

Title: Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak.

PubMed ID: 7715731

DOI: 10.1038/374736a0

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8521816

Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

PubMed ID: 8521816

DOI: 10.1002/j.1460-2075.1995.tb00246.x

PubMed ID: 10233985

Title: Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak.

PubMed ID: 10233985

DOI: 10.1128/jvi.73.6.5181-5185.1999

PubMed ID: 16439990

Title: Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis.

PubMed ID: 16439990

DOI: 10.1038/sj.cdd.4401853

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 25296756

Title: Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.

PubMed ID: 25296756

DOI: 10.1074/jbc.m114.567792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 9020082

Title: Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

PubMed ID: 9020082

DOI: 10.1126/science.275.5302.983

PubMed ID: 17157251

Title: The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.

PubMed ID: 17157251

DOI: 10.1016/j.molcel.2006.10.014

PubMed ID: 17386268

Title: A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.

PubMed ID: 17386268

DOI: 10.1016/j.molcel.2007.02.004

Sequence Information:

  • Length: 211
  • Mass: 23409
  • Checksum: A2200FE72A46D04E
  • Sequence:
    • MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQEQEAE GVAAPADPEM 
VTLPLQPSST MGQVGRQLAI IGDDINRRYD SEFQTMLQHL QPTAENAYEY FTKIATSLFE 
SGINWGRVVA LLGFGYRLAL HVYQHGLTGF LGQVTRFVVD FMLHHCIARW IAQRGGWVAA 
LNLGNGPILN VLVVLGVVLL GQFVVRRFFK S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.