Details for: CCAR2
Associated with
Other Information
Genular Protein ID: 2933247973
Symbol: CCAR2_HUMAN
Name: Cell cycle and apoptosis regulator protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11853319
Title: Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.
PubMed ID: 11853319
PubMed ID: 12370419
Title: DBC2, a candidate for a tumor suppressor gene involved in breast cancer.
PubMed ID: 12370419
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18445686
Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.
PubMed ID: 18445686
DOI: 10.1242/jcs.019174
PubMed ID: 18235501
PubMed ID: 18235502
Title: Negative regulation of the deacetylase SIRT1 by DBC1.
PubMed ID: 18235502
DOI: 10.1038/nature06515
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19131338
Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.
PubMed ID: 19131338
PubMed ID: 19218236
Title: Inhibition of SUV39H1 methyltransferase activity by DBC1.
PubMed ID: 19218236
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20074560
Title: Repression of estrogen receptor beta function by putative tumor suppressor DBC1.
PubMed ID: 20074560
PubMed ID: 20160719
Title: Identification of DBC1 as a transcriptional repressor for BRCA1.
PubMed ID: 20160719
PubMed ID: 21030595
Title: HDAC3 is negatively regulated by the nuclear protein DBC1.
PubMed ID: 21030595
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22735644
Title: DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.
PubMed ID: 22735644
DOI: 10.1093/jmcb/mjs035
PubMed ID: 22446626
Title: DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.
PubMed ID: 22446626
DOI: 10.1038/nature10925
PubMed ID: 23398316
Title: DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha.
PubMed ID: 23398316
DOI: 10.1042/bj20121085
PubMed ID: 23841676
Title: Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer.
PubMed ID: 23841676
DOI: 10.1042/bsr20130062
PubMed ID: 23352644
Title: Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage.
PubMed ID: 23352644
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24273392
Title: A functional proteomics perspective of dbc1 as a regulator of transcription.
PubMed ID: 24273392
PubMed ID: 24126058
Title: hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
PubMed ID: 24126058
DOI: 10.1128/mcb.00874-13
PubMed ID: 24415752
Title: Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.
PubMed ID: 24415752
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25406032
Title: Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.
PubMed ID: 25406032
DOI: 10.1038/ncomms6483
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25361978
Title: Chk2 and REGgamma-dependent DBC1 regulation in DNA damage induced apoptosis.
PubMed ID: 25361978
DOI: 10.1093/nar/gku1065
PubMed ID: 25732823
Title: DBC1 functions as a tumor suppressor by regulating p53 stability.
PubMed ID: 25732823
PubMed ID: 24824780
Title: MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.
PubMed ID: 24824780
DOI: 10.1002/ijc.28967
PubMed ID: 24962073
Title: CK2alpha phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients.
PubMed ID: 24962073
DOI: 10.1002/ijc.29043
PubMed ID: 25661920
Title: CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase.
PubMed ID: 25661920
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 923
- Mass: 102902
- Checksum: 1733934377E35D21
- Sequence:
MSQFKRQRIN PLPGGRNFSG TASTSLLGPP PGLLTPPVAT ELSQNARHLQ GGEKQRVFTG IVTSLHDYFG VVDEEVFFQL SVVKGRLPQL GEKVLVKAAY NPGQAVPWNA VKVQTLSNQP LLKSPAPPLL HVAALGQKQG ILGAQPQLIF QPHRIPPLFP QKPLSLFQTS HTLHLSHLNR FPARGPHGRL DQGRSDDYDS KKRKQRAGGE PWGAKKPRHD LPPYRVHLTP YTVDSPICDF LELQRRYRSL LVPSDFLSVH LSWLSAFPLS QPFSLHHPSR IQVSSEKEAA PDAGAEPITA DSDPAYSSKV LLLSSPGLEE LYRCCMLFVD DMAEPRETPE HPLKQIKFLL GRKEEEAVLV GGEWSPSLDG LDPQADPQVL VRTAIRCAQA QTGIDLSGCT KWWRFAEFQY LQPGPPRRLQ TVVVYLPDVW TIMPTLEEWE ALCQQKAAEA APPTQEAQGE TEPTEQAPDA LEQAADTSRR NAETPEATTQ QETDTDLPEA PPPPLEPAVI ARPGCVNLSL HGIVEDRRPK ERISFEVMVL AELFLEMLQR DFGYRVYKML LSLPEKVVSP PEPEKEEAAK EEATKEEEAI KEEVVKEPKD EAQNEGPATE SEAPLKEDGL LPKPLSSGGE EEEKPRGEAS EDLCEMALDP ELLLLRDDGE EEFAGAKLED SEVRSVASNQ SEMEFSSLQD MPKELDPSAV LPLDCLLAFV FFDANWCGYL HRRDLERILL TLGIRLSAEQ AKQLVSRVVT QNICQYRSLQ YSRQEGLDGG LPEEVLFGNL DLLPPPGKST KPGAAPTEHK ALVSHNGSLI NVGSLLQRAE QQDSGRLYLE NKIHTLELKL EESHNRFSAT EVTNKTLAAE MQELRVRLAE AEETARTAER QKSQLQRLLQ ELRRRLTPLQ LEIQRVVEKA DSWVEKEEPA PSN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.