GRHL3 | ENSG00000158055 | NCBI 57822

Details for: GRHL3

Gene ID: 57822

Symbol: GRHL3

Ensembl ID: ENSG00000158055

Description: grainyhead like transcription factor 3

Associated with

Central nervous system development
(GO:0007417)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Cochlea morphogenesis
(GO:0090103)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Ectoderm development
(GO:0007398)
Epidermis development
(GO:0008544)
Establishment of planar polarity
(GO:0001736)
Establishment of skin barrier
(GO:0061436)
Eyelid development in camera-type eye
(GO:0061029)
Neural tube closure
(GO:0001843)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pattern specification process
(GO:0007389)
Planar cell polarity pathway involved in neural tube closure
(GO:0090179)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Transcription by rna polymerase ii
(GO:0006366)
Wound healing
(GO:0042060)

Other Information

Proteins

Sister of mammalian grainyhead

Genular Protein ID: 2211044236

Symbol: GRHL3_HUMAN

Name: Sister of mammalian grainyhead

UniProtKB Accession Codes:

Q8TE85 A2A297 B2RCL1 G3XAF0 Q5TH78 Q86Y06 Q8N407

Database IDs:

Citations:

PubMed ID: 12549979

Title: The identification and characterization of human sister-of-mammalian grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.

PubMed ID: 12549979

DOI: 10.1042/bj20021476

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21081122

Title: The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.

PubMed ID: 21081122

DOI: 10.1016/j.ydbio.2010.11.011

PubMed ID: 25347468

Title: A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia.

PubMed ID: 25347468

DOI: 10.1172/jci77138

PubMed ID: 24360809

Title: Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development.

PubMed ID: 24360809

DOI: 10.1016/j.ajhg.2013.11.009

Sequence Information:

Length: 626
Mass: 70345
Checksum: 225C0E2049FF0CE6
Sequence:

MSNELDFRSV RLLKNDPVNL QKFSYTSEDE AWKTYLENPL TAATKAMMRV NGDDDSVAAL 
SFLYDYYMGP KEKRILSSST GGRNDQGKRY YHGMEYETDL TPLESPTHLM KFLTENVSGT 
PEYPDLLKKN NLMSLEGALP TPGKAAPLPA GPSKLEAGSV DSYLLPTTDM YDNGSLNSLF 
ESIHGVPPTQ RWQPDSTFKD DPQESMLFPD ILKTSPEPPC PEDYPSLKSD FEYTLGSPKA 
IHIKSGESPM AYLNKGQFYP VTLRTPAGGK GLALSSNKVK SVVMVVFDNE KVPVEQLRFW 
KHWHSRQPTA KQRVIDVADC KENFNTVEHI EEVAYNALSF VWNVNEEAKV FIGVNCLSTD 
FSSQKGVKGV PLNLQIDTYD CGLGTERLVH RAVCQIKIFC DKGAERKMRD DERKQFRRKV 
KCPDSSNSGV KGCLLSGFRG NETTYLRPET DLETPPVLFI PNVHFSSLQR SGGAAPSAGP 
SSSNRLPLKR TCSPFTEEFE PLPSKQAKEG DLQRVLLYVR RETEEVFDAL MLKTPDLKGL 
RNAISEKYGF PEENIYKVYK KCKRGETSLL HPRLSRHPPP DCLECSHPVT QVRNMGFGDG 
FWRQRDLDSN PSPTTVNSLH FTVNSE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GRHL3

Associated with

Other Information

The identification and characterization of human sister-of-mammalian grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors. PubMed ID: 12549979

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. PubMed ID: 21081122

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia. PubMed ID: 25347468

Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development. PubMed ID: 24360809