Angptl4 | ENSMUSG00000002289 | NCBI 57875

Details for: Angptl4

Gene ID: 57875

Symbol: Angptl4

Ensembl ID: ENSMUSG00000002289

Description: angiopoietin-like 4

Associated with

Adherens junctions interactions
(R-MMU-418990)
Assembly of active lpl and lipc lipase complexes
(R-MMU-8963889)
Cell-cell communication
(R-MMU-1500931)
Cell-cell junction organization
(R-MMU-421270)
Cell junction organization
(R-MMU-446728)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein remodeling
(R-MMU-8963899)
Regulation of cdh11 expression and function
(R-MMU-9759475)
Regulation of cdh11 function
(R-MMU-9762292)
Regulation of expression and function of type ii classical cadherins
(R-MMU-9764260)
Regulation of homotypic cell-cell adhesion
(R-MMU-9759476)
Transport of small molecules
(R-MMU-382551)
Angiogenesis
(GO:0001525)
Cellular response to starvation
(GO:0009267)
Collagen-containing extracellular matrix
(GO:0062023)
Endothelial cell apoptotic process
(GO:0072577)
Enzyme inhibitor activity
(GO:0004857)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Lipid metabolic process
(GO:0006629)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of lipoprotein lipase activity
(GO:0051005)
Positive regulation of lipid metabolic process
(GO:0045834)
Protein unfolding
(GO:0043335)
Triglyceride homeostasis
(GO:0070328)

Other Information

Proteins

Angiopoietin-related protein 4

Genular Protein ID: 3615312850

Symbol: ANGL4_MOUSE

Name: Angiopoietin-related protein 4

UniProtKB Accession Codes:

Q9Z1P8 Q78ZJ9 Q9JHX7 Q9JLX7

Database IDs:

Citations:

PubMed ID: 10698685

Title: Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis.

PubMed ID: 10698685

DOI: 10.1042/bj3460603

PubMed ID: 10862772

Title: Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene.

PubMed ID: 10862772

DOI: 10.1074/jbc.m004029200

PubMed ID: 14583458

Title: Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.

PubMed ID: 14583458

PubMed ID: 10866690

Title: Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.

PubMed ID: 10866690

DOI: 10.1128/mcb.20.14.5343-5349.2000

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15112104

Title: Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.

PubMed ID: 15112104

DOI: 10.1007/s00335-003-2329-1

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15837923

Title: Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.

PubMed ID: 15837923

DOI: 10.1073/pnas.0408452102

PubMed ID: 17068295

Title: Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton.

PubMed ID: 17068295

DOI: 10.1161/01.res.0000250758.63358.91

PubMed ID: 17130448

Title: Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness.

PubMed ID: 17130448

DOI: 10.1073/pnas.0609025103

PubMed ID: 17609370

Title: Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.

PubMed ID: 17609370

DOI: 10.1073/pnas.0705041104

PubMed ID: 21832056

Title: Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.

PubMed ID: 21832056

DOI: 10.1074/jbc.m111.220061

PubMed ID: 29899519

Title: Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

PubMed ID: 29899519

DOI: 10.1038/s41467-018-04611-z

Sequence Information:

Length: 410
Mass: 45538
Checksum: BCEE2259921D6D81
Sequence:

MRCAPTAGAA LVLCAATAGL LSAQGRPAQP EPPRFASWDE MNLLAHGLLQ LGHGLREHVE 
RTRGQLGALE RRMAACGNAC QGPKGKDAPF KDSEDRVPEG QTPETLQSLQ TQLKAQNSKI 
QQLFQKVAQQ QRYLSKQNLR IQNLQSQIDL LAPTHLDNGV DKTSRGKRLP KMTQLIGLTP 
NATHLHRPPR DCQELFQEGE RHSGLFQIQP LGSPPFLVNC EMTSDGGWTV IQRRLNGSVD 
FNQSWEAYKD GFGDPQGEFW LGLEKMHSIT GNRGSQLAVQ LQDWDGNAKL LQFPIHLGGE 
DTAYSLQLTE PTANELGATN VSPNGLSLPF STWDQDHDLR GDLNCAKSLS GGWWFGTCSH 
SNLNGQYFHS IPRQRQERKK GIFWKTWKGR YYPLQATTLL IQPMEATAAS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Angptl4

Associated with

Other Information

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. PubMed ID: 10698685

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. PubMed ID: 10862772

Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. PubMed ID: 14583458

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. PubMed ID: 10866690

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. PubMed ID: 15112104

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. PubMed ID: 15837923

Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. PubMed ID: 17068295

Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. PubMed ID: 17130448

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. PubMed ID: 17609370

Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice. PubMed ID: 21832056

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. PubMed ID: 29899519