Details for: NKX3 2

Gene ID: 579

Symbol: NKX3 2

Ensembl ID: ENSG00000109705

Description: NK3 homeobox 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.46
    Marker Score: 4243
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.39
    Marker Score: 2408
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.25
    Marker Score: 4105.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.9
    Marker Score: 2124
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1183
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.04
    Marker Score: 590.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.9
    Marker Score: 954.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.85
    Marker Score: 1768
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 491
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.82
    Marker Score: 432
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.76
    Marker Score: 1793
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1196
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.74
    Marker Score: 2854
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 518
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.59
    Marker Score: 206
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.56
    Marker Score: 7414
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.5
    Marker Score: 266
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.43
    Marker Score: 812
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6575
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 265
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 234
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.36
    Marker Score: 723
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.32
    Marker Score: 863
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.32
    Marker Score: 581
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.31
    Marker Score: 3123
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.29
    Marker Score: 109
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1620
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 210
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.23
    Marker Score: 235
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.23
    Marker Score: 127.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.23
    Marker Score: 177
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 424
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.15
    Marker Score: 34
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 153
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.09
    Marker Score: 387
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 22.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.09
    Marker Score: 189
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 116
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.08
    Marker Score: 137
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.07
    Marker Score: 19.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: endosteal cell (CL0002157)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 92
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 22.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 75.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.05
    Marker Score: 56.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.04
    Marker Score: 110
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.03
    Marker Score: 23

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Other Information

**Key characteristics:** - NKX3.2 is a homeobox gene, which are a family of transcription factors that are involved in various developmental processes. - It is a key regulator of middle ear development, as it is expressed in cells that are responsible for the formation of the middle ear. - NKX3.2 is a key regulator of the expression of other genes involved in middle ear development, such as Runx2 and Rna polymerase ii. **Pathways and functions:** - NKX3.2 is involved in cell differentiation, as it is expressed in cells that are committed to becoming epithelial cells. - It is also involved in the determination of left/right symmetry in the middle ear, as it is expressed in cells on one side of the head and neck. - NKX3.2 is a key regulator of the development of the middle ear, as it is required for the formation of the middle ear structures. - It is also involved in the regulation of apoptosis, chondrocyte differentiation, and transcription by rna polymerase ii. **Clinical significance:** - Mutations in the NKX3.2 gene have been linked to several human diseases, including middle ear malformations and hearing loss. - Targeting NKX3.2 has been investigated as a potential therapeutic strategy for these diseases. **Additional information:** - NKX3.2 is a highly conserved gene, with a similar gene found in other vertebrates. - It is a key transcription factor that plays a crucial role in the development and maintenance of the middle ear. - Understanding the role of NKX3.2 is important for understanding the development of human middle ear malformations and hearing loss.

Genular Protein ID: 2102903824

Symbol: NKX32_HUMAN

Name: Homeobox protein Nkx-3.2

UniProtKB Accession Codes:

P78367 Q2M2I7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9426254

Title: Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe.

PubMed ID: 9426254

DOI: 10.1016/s0378-1119(97)00520-9

PubMed ID: 9344671

Title: Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.

PubMed ID: 9344671

DOI: 10.1006/geno.1997.4926

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9256352

Title: Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton.

PubMed ID: 9256352

DOI: 10.1016/s0925-4773(97)00067-1

PubMed ID: 20004766

Title: Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.

PubMed ID: 20004766

DOI: 10.1016/j.ajhg.2009.11.005

Sequence Information:

  • Length: 333
  • Mass: 34814
  • Checksum: 8C406E188D27780B
  • Sequence:
    • MAVRGANTLT SFSIQAILNK KEERGGLAAP EGRPAPGGTA ASVAAAPAVC CWRLFGERDA 
GALGGAEDSL LASPAGTRTA AGRTAESPEG WDSDSALSEE NESRRRCADA RGASGAGLAG 
GSLSLGQPVC ELAASKDLEE EAAGRSDSEM SASVSGDRSP RTEDDGVGPR GAHVSALCSG 
AGGGGGSGPA GVAEEEEEPA APKPRKKRSR AAFSHAQVFE LERRFNHQRY LSGPERADLA 
ASLKLTETQV KIWFQNRRYK TKRRQMAADL LASAPAAKKV AVKVLVRDDQ RQYLPGEVLR 
PPSLLPLQPS YYYPYYCLPG WALSTCAAAA GTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.