Details for: NKX3 2

Gene ID: 579

Symbol: NKX3 2

Ensembl ID: ENSG00000109705

Description: NK3 homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.2180
    Cell Significance Index: 20.8200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.3628
    Cell Significance Index: 3.5900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.2261
    Cell Significance Index: 1.1900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0819
    Cell Significance Index: 1.3000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0495
    Cell Significance Index: 0.3100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.0375
    Cell Significance Index: 0.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0029
    Cell Significance Index: 0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0032
    Cell Significance Index: -2.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0032
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0049
    Cell Significance Index: -2.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0050
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0059
    Cell Significance Index: -1.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0071
    Cell Significance Index: -0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0101
    Cell Significance Index: -2.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0108
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0115
    Cell Significance Index: -1.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0125
    Cell Significance Index: -2.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0137
    Cell Significance Index: -0.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0141
    Cell Significance Index: -2.5500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0169
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0175
    Cell Significance Index: -2.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0184
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0192
    Cell Significance Index: -2.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0195
    Cell Significance Index: -2.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0219
    Cell Significance Index: -0.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0237
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0238
    Cell Significance Index: -2.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0251
    Cell Significance Index: -0.4900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0258
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0265
    Cell Significance Index: -0.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0303
    Cell Significance Index: -0.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0373
    Cell Significance Index: -1.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0382
    Cell Significance Index: -1.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0385
    Cell Significance Index: -0.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0392
    Cell Significance Index: -2.2000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0411
    Cell Significance Index: -0.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0423
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0478
    Cell Significance Index: -1.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0492
    Cell Significance Index: -2.2300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0521
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0528
    Cell Significance Index: -0.5800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0555
    Cell Significance Index: -0.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0572
    Cell Significance Index: -2.1000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0587
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0588
    Cell Significance Index: -0.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0608
    Cell Significance Index: -0.8300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0678
    Cell Significance Index: -0.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0679
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0702
    Cell Significance Index: -0.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0722
    Cell Significance Index: -1.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0725
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0726
    Cell Significance Index: -2.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0737
    Cell Significance Index: -2.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0741
    Cell Significance Index: -2.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0746
    Cell Significance Index: -2.6200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0750
    Cell Significance Index: -0.9500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0754
    Cell Significance Index: -0.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0769
    Cell Significance Index: -2.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0786
    Cell Significance Index: -2.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0788
    Cell Significance Index: -1.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0789
    Cell Significance Index: -2.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0792
    Cell Significance Index: -1.1500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0816
    Cell Significance Index: -1.1100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0821
    Cell Significance Index: -1.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0829
    Cell Significance Index: -2.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0879
    Cell Significance Index: -2.5900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0882
    Cell Significance Index: -1.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0883
    Cell Significance Index: -2.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0889
    Cell Significance Index: -1.3500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0893
    Cell Significance Index: -0.9600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0901
    Cell Significance Index: -1.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0913
    Cell Significance Index: -2.1100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0940
    Cell Significance Index: -0.9600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0943
    Cell Significance Index: -1.2200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0955
    Cell Significance Index: -1.0200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0958
    Cell Significance Index: -0.9900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0963
    Cell Significance Index: -1.0900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0964
    Cell Significance Index: -1.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0970
    Cell Significance Index: -1.0600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0992
    Cell Significance Index: -1.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1010
    Cell Significance Index: -2.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1038
    Cell Significance Index: -2.7300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.1081
    Cell Significance Index: -0.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1098
    Cell Significance Index: -1.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1104
    Cell Significance Index: -1.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1150
    Cell Significance Index: -2.7900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1158
    Cell Significance Index: -1.5900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1163
    Cell Significance Index: -1.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1185
    Cell Significance Index: -2.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1187
    Cell Significance Index: -2.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1189
    Cell Significance Index: -0.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NKX3.2 is a member of the NKX homeobox gene family, which is composed of six genes (NKX2, NKX3, NKX3.1, NKX3.2, NKX6, and NKX8) that are involved in embryonic development and tissue patterning. NKX3.2 is specifically expressed in various cell types, including T cells, endothelial cells, microglia, plasma cells, B cells, goblet cells, megakaryocytes, and neurons in the cerebral cortex. Its expression pattern suggests a broad role in regulating cell fate decisions, differentiation, and survival. **Pathways and Functions:** NKX3.2 is involved in several signaling pathways that regulate embryonic development, immune cell function, and tissue homeostasis. Some of the key pathways and functions include: 1. **Animal Organ Formation:** NKX3.2 regulates the development of various organs, including the skeletal system, pancreas, and middle ear, by controlling the expression of target genes involved in cell differentiation and proliferation. 2. **Cell Differentiation:** NKX3.2 acts as a transcriptional repressor, regulating the expression of genes involved in cell differentiation, such as chondrocyte differentiation and GABAergic neuron development. 3. **Apoptosis Regulation:** NKX3.2 inhibits apoptosis in certain cell types, including megakaryocytes and endothelial cells, by regulating the expression of anti-apoptotic genes. 4. **Immune Cell Function:** NKX3.2 is expressed in immune cells, including T cells, B cells, and plasma cells, and regulates their development, function, and survival. 5. **Transcriptional Regulation:** NKX3.2 interacts with other transcription factors, such as RUNX2, to regulate gene expression and tissue development. **Clinical Significance:** Dysregulation of NKX3.2 has been implicated in various diseases, including: 1. **Immune-Mediated Disorders:** NKX3.2 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where dysregulation of immune cell function contributes to disease pathogenesis. 2. **Neurological Disorders:** Alterations in NKX3.2 expression have been observed in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where disruptions in neuronal development and function contribute to disease pathology. 3. **Cancer:** NKX3.2 has been identified as a potential oncogene in certain types of cancer, including breast cancer and leukemia, where its overexpression contributes to tumorigenesis and cancer progression. In conclusion, NKX3.2 is a multifunctional transcription factor that plays a critical role in regulating embryonic development, immune cell function, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying NKX3.2 function and its role in disease pathogenesis.

Genular Protein ID: 2102903824

Symbol: NKX32_HUMAN

Name: Homeobox protein Nkx-3.2

UniProtKB Accession Codes:

P78367 Q2M2I7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9426254

Title: Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe.

PubMed ID: 9426254

DOI: 10.1016/s0378-1119(97)00520-9

PubMed ID: 9344671

Title: Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.

PubMed ID: 9344671

DOI: 10.1006/geno.1997.4926

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9256352

Title: Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton.

PubMed ID: 9256352

DOI: 10.1016/s0925-4773(97)00067-1

PubMed ID: 20004766

Title: Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.

PubMed ID: 20004766

DOI: 10.1016/j.ajhg.2009.11.005

Sequence Information:

  • Length: 333
  • Mass: 34814
  • Checksum: 8C406E188D27780B
  • Sequence:
    • MAVRGANTLT SFSIQAILNK KEERGGLAAP EGRPAPGGTA ASVAAAPAVC CWRLFGERDA 
GALGGAEDSL LASPAGTRTA AGRTAESPEG WDSDSALSEE NESRRRCADA RGASGAGLAG 
GSLSLGQPVC ELAASKDLEE EAAGRSDSEM SASVSGDRSP RTEDDGVGPR GAHVSALCSG 
AGGGGGSGPA GVAEEEEEPA APKPRKKRSR AAFSHAQVFE LERRFNHQRY LSGPERADLA 
ASLKLTETQV KIWFQNRRYK TKRRQMAADL LASAPAAKKV AVKVLVRDDQ RQYLPGEVLR 
PPSLLPLQPS YYYPYYCLPG WALSTCAAAA GTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.